Chronic insulin treatment suppresses PTP1B function, induces increased PDGF signaling, and amplifies neointima formation in the balloon-injured rat artery

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 1, 2009, Pages

  Pu, Qinghua ^a,b   Chang, Yingzi ^a,c   Zhang, Chunxiang ^a,d   Cai, Yi ^a   Hassid, Aviv ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Dept of Physiology ^*  (United States)

^c A T STILL UNIVERSITY   (United States)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Platelet derived growth factor; Protein tyrosine phosphatase 1B; Restenosis; Reverse transcription polymerase chain reaction; Vascular injury

Indexed keywords

INSULIN; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE PHOSPHATASE 1B; TYROSINE;

ANIMAL MODEL; ARTERY INTIMA PROLIFERATION; ARTICLE; BALLOON CATHETER; BLOOD PRESSURE MEASUREMENT; BODY WEIGHT; CAROTID ARTERY INJURY; CATECHOLAMINE URINE LEVEL; COMPUTER ASSISTED TOMOGRAPHY; CONTROL GROUP; CONTROLLED STUDY; DISEASE DURATION; ENZYME ACTIVITY; ENZYME REPRESSION; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYDROCORTISONE BLOOD LEVEL; HYPERINSULINEMIA; IMMUNOPHOSPHATASE TECHNIQUE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN TREATMENT; INTIMA; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION; SHAM PROCEDURE; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; BALLOON DILATATION; BLOOD GLUCOSE; CAROTID ARTERY INJURIES; CATECHOLAMINES; HYDROCORTISONE; HYPERINSULINISM; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENOUS; INSULIN; MALE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 58149520029     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00370.2008     Document Type: Article

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