Insulin resistance/compensatory hyperinsulinemia predict carotid intimal medial thickness in patients with essential hypertension

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 16, Issue 1, 2006, Pages 22-27

  Zavaroni, Ivana ^a   Ardigò, Diego ^a   Zuccarelli, Alessandra ^b   Pacetti, Edoarda ^a   Piatti, Pier M ^c   Monti, Lucilla ^c   Valtueña, Silvia ^a   Massironi, Paola ^a   Rossi, Pier C ^b   Reaven, Gerald M ^d  

^a UNIVERSITY OF PARMA   (Italy)

^b Pontremoli and Fivizzano Hospitals   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d STANFORD UNIVERSITY   (United States)

Author keywords

Essential hypertension; Insulin resistance; Intima media thickness

Indexed keywords

EID: 33645983184     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2004.11.003     Document Type: Article

References (27)

1. Ferrannini E, Buzzigoli G, Bonadona R. Insulin resistance in essential hypertension. N Engl J Med 1987;317:350-7.
2. Swislocki ALM, Hoffman BB, Reaven GM. Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension. Am J Hypertens 1989;2:419-23.
3. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism 1990;39:167-74.
4. Ferrari P, Weidmann P, Shaw S, et al. Altered insulin sensitivity, hyperinsulinemia and dyslipidemia in individuals with a hypertensive parent. Am J Med 1991;91:589-96.
5. Facchini F, Chen Y-DI, Clinkingbeard C, Jeppesen J, Reaven GM. Insulin resistance, hyperinsulinemia, and dyslipidemia in nonobese individuals with a family history of hypertension. Am J Hypertens 1992;5:694-9.
6. Allemann Y, Horber FF, Colombo M, et al. Insulin sensitivity and body fat distribution in normotensive offspring of hypertensive parents. Lancet 1993;341:327-31.
7. Skarfors ET, Lithell HO, Selinus I. Risk factors for the development of hypertension: a 10-year longitudinal study in middle-aged men. J Hypertens 1991;9:217-23.
8. Lissner L, Bengtsson C, Lapidus L, Kristjansson K, Wedel H. Fasting insulin in relation to subsequent blood pressure changes and hypertension in women. Hypertension 1992;20:797-801.
9. Taittonen L, Uhari M, Nuutinen M, Turtinen J, Pokka T, Akerblom HK. Insulin and blood pressure among healthy children. Am J Hypertens 1996;9:193-9.
10. Raitakari OT, Porkka KVK, Rönnemaa T, et al. The role of insulin in clustering of serum lipids and blood pressure in children and adolescents. Diabetologia 1995;38:1042-50.
11. Zavaroni I, Mazza S, Dall'Aglio E, Gasparini P, Passeri M, Reaven GM. Prevalence of hyperinsulinaemia in patients with high blood pressure. J Intern Med 1992;231:235-40.
12. Jeppesen J, Hein HO, Suadicani P, Gynelberg F. High triglycerides and low HDL cholesterol and blood pressure and risk of ischemic heart disease. Hypertension 2000;36:226-39.
13. Jeppesen J, Hein HO, Suadicani P, Gynterberg F. Low triglycerides-high high-density lipoprotein cholesterol and risk of ischemic heart disease. Arch Intern Med 2001;161:361-6.
14. Sheu WH-H, Jeng C-Y, Shieh S-M, et al. Insulin resistance and abnormal electrocardiograms in patients with high blood pressure. Am J Hypertens 1992;5:444-8.
15. Zavaroni I, Ardigo D, Massironi P, et al. Do coronary heart disease risk factors change over time? Metabolism 2002;51:1022-6.
16. Zavaroni I, Platti PM, Monti LD, et al. Plasma nitric oxide concentrations are elevated in insulin-resistant healthy subjects. Metabolism 2000;49:959-61.
17. Borhani NO, Mercuri M, Borhani PA, et al. Final outcome results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS): a randomized control trial. J Am Med Assoc 1996;276:785-91.
18. Zanchetti A, Crepaldi G, Bond MG, et al. Systolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol) are associated with alterations in carotid intima-media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lowering Italian Study. PHYLLIS study group. J Hypertens 2001;19:79-88.
19. Howard G, Sharrett AR, Heiss G, et al. Carotid intima-media thickness distribution in general population as evaluated by B-mode ultrasound. ARIC investigators. Stroke 1993;24:1297-304.
20. Pauletto P, Puato M, Faggin E, et al. Specific cellular features of atheroma associated with development of neointima after carotid endarterectomy: the carotid atherosclerosis and restenosis study. Circulation 2000;102:771-8.
21. Bonora E, Tessari R, Micciolo R, Zenere M, Targher G, Padovani R, et al. Intimal-medial thickness of the carotid artery in nondiabetic and NIDDM patients. Relationship with insulin resistance. Diabetes Care 1997;20(4):627-31.
22. De Pergola G, Ciccone M, Pannacciulli N, Modugno M, Sciaraffia M, Minenna A, et al. Lower insulin sensitivity as an independent risk factor for carotid wall thickening in normotensive, non-diabetic, non-smoking normal weight and obese premenopausal women. Int J Obes Relat Metab Disord 2000;24(7):825-9.
23. Wang PW, Liou CW, Wang ST, Eng HL, Liu RT, Tung SC, et al. Relative impact of low-density lipoprotein-cholesterol concentration and insulin resistance on carotid wall thickening in nondiabetic, normotensive volunteers. Metabolism 2002;51(2):255-9.
24. Pearson TA. New tools for coronary risk assessment. What are their advantages and limitations? Circulation 2002;105:886-92.
25. Chambless LE, Heiss G, Folsom AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol 1997;146:483-94.
26. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson Jr SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults; Cardiovascular Health Study. N Engl J Med 1999;340:14-22.
27. Reaven GM, Lithell H, Landsberg L. Hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system. N Engl J Med 1996;334:374-81.