Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 296, Issue 1, 2009, Pages

  Yoshioka, Masakata ^a   Sagara, Hironori ^b   Takahashi, Fumiyuki ^a   Harada, Norihiro ^a   Nishio, Kazuto ^c   Mori, Akio ^d   Ushio, Hiroko ^a   Shimizu, Kazue ^a   Okada, Takenori ^b   Ota, Mayumi ^b   Ito, Yoichi M ^e   Nagashima, Osamu ^a   Atsuta, Ryo ^a   Suzuki, Toshihiro ^f   Fukuda, Takeshi ^b   Fukuchi, Yoshinosuke ^a   Takahashi, Kazuhisa ^a  

^a JUNTENDO UNIVERSITY   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

^c KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d SAGAMIHARA NATIONAL HOSPITAL   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cysteinyl leukotrienes; Mast cell

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; MULTIDRUG RESISTANCE PROTEIN 1; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BONE MARROW CELL; CELL HYPERPLASIA; CONTROLLED STUDY; GENE EXPRESSION; GOBLET CELL; LUNG LAVAGE; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYSTEINE; HYPERSENSITIVITY; IMMUNOGLOBULIN E; LEUKOTRIENES; LUNG; MAST CELLS; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OVALBUMIN; PNEUMONIA;

EID: 58149506377     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00026.2008     Document Type: Article

References (31)

1. Bandi N, Kompella UB. Budesonide reduces multidrug resistance-associated protein 1 expression in an airway epithelial cell line (Calu-1). Eur J Pharmacol 437: 9-17, 2002.
2. Bartosz G, Konig J, Keppler D, Hagmann W. Human mast cells secreting leukotriene C4 express the MRP1 gene-encoded conjugate export pump. Biol Chem 379: 1121-1126, 1998.
3. Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 92: 1295-1302, 2000.
4. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 344: 350-362, 2001.
5. Campbell BJ, Baker SF, Shukla SD, Forrester LJ, Zahler WL. Bioconversion of leukotriene D4 by lung dipeptidase. Biochim Biophys Acta 1042: 107-112, 1990.
6. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654, 1992.
7. Deeley RG, Westlake C, Cole SP. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 86: 849-899, 2006.
8. Drazen JM, Israel E, O'Byrne PM. Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 340: 197-206, 1999.
9. Duan W, Chan JH, Wong CH, Leung BP, Wong WS. Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. J Immunol 172: 7053-7059, 2004.
10. Flens MJ, Zaman GJ, van der Valk P, Izquierdo MA, Schroeijers AB, Scheffer GL, van der Groep P, de Haas M, Meijer CJ, Scheper RJ. Tissue distribution of the multidrug resistance protein. Am J Pathol 148: 1237-1247, 1996.
11. Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana ST, Ikeda S, Okumura K, Ogawa H. The extra domain A of fibronectin stimulates murine mast cells via Toll-like receptor 4. J Leukoc Biol 82: 657-665, 2007.
12. Henderson WR Jr. The role of leukotrienes in inflammation. Ann Intern Med 121: 684-697, 1994.
13. Henderson WR Jr, Lewis DB, Albert RK, Zhang Y, Lamm WJ, Chiang GK, Jones F, Eriksen P, Tien YT, Jonas M, Chi EY. The importance of leukotrienes in airway inflammation in a mouse model of asthma. J Exp Med 184: 1483-1494, 1996.
14. Henderson WR Jr, Tang LO, Chu SJ, Tsao SM, Chiang GK, Jones F, Jonas M, Pae C, Wang H, Chi EY. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 165: 108-116, 2002.
15. Hipfner DR, Deeley RG, Cole SP. Structural, mechanistic and clinical aspects of MRP1. Biochim Biophys Acta 1461: 359-376, 1999.
16. Jame AJ, Lackie PM, Cazaly AM, Sayers I, Penrose JF, Holgate ST, Sampson AP. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Clin Exp Allergy 37: 880-892, 2007.
17. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J Immunol 173: 1503-1510, 2004.
18. Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. J Immunol 176: 4440-4448, 2006.
19. Leier I, Jedlitschky G, Buchholz U, Cole SP, Deeley RG, Keppler D. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 269: 27807-27810, 1994.
20. Leier I, Jedlitschky G, Buchler M, Buchholz U, Brom M, Keppler D. Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein. Eur J Biochem 242: 201-205, 1996.
21. Lima JJ, Zhang S, Grant A, Shao L, Tantisira KG, Allayee H, Wang J, Sylvester J, Holbrook J, Wise R, Weiss ST, Barnes K. Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med 173: 379-385, 2006.
22. Machida I, Matsuse H, Kondo Y, Kawano T, Saeki S, Tomari S, Obase Y, Fukushima C, Kohno S. Cysteinyl leukotrienes regulate dendritic cell functions in a murine model of asthma. J Immunol 172: 1833-1838, 2004.
23. Penrose JF, Austen KF. The biochemical, molecular, and genomic aspects of leukotriene C4 synthase. Proc Assoc Am Physicians 111: 537-546, 1999.
24. Rius M, Hummel-Eisenbeiss J, Keppler D. ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4). J Pharmacol Exp Ther 324: 86-94, 2008.
25. Robbiani DF, Finch RA, Jager D, Muller WA, Sartorelli AC, Randolph GJ. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 103: 757-768, 2000.
26. Supajatura V, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H. Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol 167: 2250-2256, 2001.
27. Van de Ven R, de Jong MC, Reurs AW, Schoonderwoerd AJ, Jansen G, Hooijberg JH, Scheffer GL, de Gruijl TD, Scheper RJ. Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation. J Immunol 176: 5191-5198, 2006.
28. Van de Ven R, Scheffer GL, Reurs AW, Lindenberg JJ, Oerlemans R, Jansen G, Gillet JP, Glasgow JN, Pereboev A, Curiel DT, Scheper RJ, de Gruijl TD. A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration. Blood 112: 2353-2359, 2008.
29. Van der Deen M, de Vries EG, Timens W, Scheper RJ, Timmer-Bosscha H, Postma DS. ATP-binding cassette (ABC) transporters in normal and pathological lung. Respir Res 6: 59, 2005.
30. Van der Deen M, Timens W, Timmer-Bosscha H, van der Strate BW, Scheper RJ, Postma DS, de Vries EG, Kerstjens HA. Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice. Respir Res 8: 49, 2007.
31. Wijnholds J, Evers R, van Leusden MR, Mol CA, Zaman GJ, Mayer U, Beijnen JH, van der Valk M, Krimpenfort P, Borst P. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med 3: 1275-1279, 1997.