Neem leaf glycoprotein directs T-bet-associated type 1 immune commitment

Human Immunology

Volumn 70, Issue 1, 2009, Pages 6-15

  Bose, Anamika ^a   Chakraborty, Krishnendu ^a   Sarkar, Koustav ^a   Goswami, Shyamal ^a   Haque, Enamul ^a   Chakraborty, Tathagata ^a   Ghosh, Diptendu ^a   Roy, Soumyabrata ^a   Laskar, Subrata ^b   Baral, Rathindranath ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

^b UNIVERSITY OF BURDWAN   (India)

Author keywords

Neem leaf glycoprotein; T bet; Type 1 immune response

Indexed keywords

CD45RA ANTIGEN; CD45RO ANTIGEN; CD69 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; L SELECTIN; NEEM LEAF GLYCOPROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR T BET; TRANSCRIPTION FACTOR T BET 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; AZADIRACHTA INDICA; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DOWN REGULATION; FEMALE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; LYMPHOCYTE; MONOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PLANT LEAF; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TH1 CELL; UPREGULATION;

ADULT; ANIMALS; ANTIGENS, CD; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; AZADIRACHTA; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; FEMALE; GLYCOPROTEINS; HUMANS; INTERFERON-GAMMA; L-SELECTIN; LYMPHOCYTES; MICE; MIDDLE AGED; MONOCYTES; PHOSPHORYLATION; PLANT LEAVES; STAT TRANSCRIPTION FACTORS; T-BOX DOMAIN PROTEINS; YOUNG ADULT;

EID: 58149472374     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.09.004     Document Type: Article

References (36)

1. Mosman T.R., and Coffman R.L. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7 (1989) 145-173
2. Seder R.A., and Paul W.E. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 12 (1994) 635-673
3. Szabo S.J., Kim S.T., Costa G.L., et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000) 655-659
4. Van Ginderachter J.A., Liu Y., Geldhof A.B., et al. B7-1, IFN γ and anti-CTLA-4 co-operate to prevent T-cell tolerization during immunotherapy against a murine T-lymphoma. Int J Cancer 87 (2000) 539-547
5. Billiau A. Interferon-γ: Biology and role in pathogenesis. Adv Immunol 62 (1996) 61
6. Murphy K.M., Ouyang W., Farrar J.D., et al. Signaling and transcription in T helper development. Annu Rev Immunol 18 (2000) 451-494
7. Zisakis A., Piperi C., Themistocleous M.S., Korkolopoulou P., Boviatsis E.I., Sakas D.E., Patsouris E., Lea R.W., and Kalofoutis A. Comparative analysis of peripheral and localised cytokine secretion in glioblastoma patients. Cytokine 39 (2007) 99-105
8. Chouaib S., Paturel C.A., Chouaib F.M., Caignard A., and Blay J.Y. The host tumor immune conflict: From immunosuppression to resistance and destruction. Immunology Today 18 (1997) 493-497
9. Avradopoulos K., Mehta S., Blackinton D., and Wanebo H.J. Interleukin-10 as a possible mediator of immunosuppressive effect in patients with squamous cell carcinoma of the head and neck. Ann Surg Oncol 4 (1997) 184-190
10. Zou W. Immunosuppressive networks in the tumor environment and their therapeutic relevance. Nat Rev Cancer 5 (2005) 263-274
11. Biswas K., Chattopadhyay I., Banerjee R.K., and Bandopadhyay U. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 82 (2002) 113-120
12. Haque E., Mandal I., Pal S., and Baral R.N. Prophylactic dose of neem (Azadirachta indica) leaf preparation restricting murine tumor growth is nontoxic, hematostimulatory and immunostimulatory. Immunopharmacol Immunotoxicol 28 (2006) 1-18
13. Baral R.N., and Chattopadhyay U. Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma. Int Immunopharmacol 4 (2004) 355-366
14. Haque E., and Baral R.N. Neem (Azadirachta indica) leaf preparation induces prophylactic growth inhibition of murine Ehrlich carcinoma in Swiss and C57BL/6 by activation of NK cells and NK-T cells. Immunobiology 211 (2006) 721-731
15. Baral R.N., Mandal I., and Chattopadhyay U. Immunostimulatory neem leaf preparation acts as an adjuvant to enhance the efficacy of poorly immunogenic B16 melanoma surface antigen vaccine. Int Immunopharmacol 5 (2005) 1343-1352
16. Mandal-Ghosh I., Chattopadhyay U., and Baral R.N. Neem leaf preparation enhances Th1 type immune response and anti-tumor immunity against breast tumor associated antigen. Cancer Immunity 7 (2007) 8-17
17. Ghosh D., Bose A., Haque E., and Baral R.N. Pretreatment with neem (Azadirachta indica) leaf preparation in Swiss mice diminishes leukopenia and enhances anti-tumor activity of cyclophosphamide. Phytother Res 20 (2006) 814-818
18. Bose A., and Baral R.N. NK cellular cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L mediated endogenous production of IL-12. Human Immunol 68 (2007) 823-831
19. Sarkar K., Bose A., Laskar S., et al. Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. Int Immunopharmacol 7 (2007) 306-312
20. Chakraborty K., Bose A., Pal S., et al. Neem leaf glycoprotein restores the impaired chemotactic activity of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by maintaining CXCR3/CXCL10 balance. Int Immunopharmacol 8 (2008) 330-340
21. Huang S., Aguet M., and Vilcek J. Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor. Proc Natl Acad Sci USA 90 (1993) 6626-6636
22. Murata Y., Amao M., Yoneda J., and Hamuro J. Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging. Mol Immunol 38 (2001) 747-757
23. Murata Y., Shimamura T., and Hamuro J. The polarization of Th1/Th2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production. Int Immunol 14 (2002) 201-212
24. + T cells. Immunology 87 (1996) 86-90
25. Harimaya A, Himi T, Fujii N, et al. Induction of CD69 expression and Th1 cytokines release from human peripheral blood lymphocytes after in vitro stimulation with Alloiococcus otidis and three middle ear pathogens. FEMS Immunol Med Microbiol 20056; 43:385-91.
26. Baleeiro R.B., Anselmo L.B., Soares F.A., et al. High frequency of immature dendritic cells and altered in situ production of interleukin-4 and tumor necrosis factor-alpha in lung cancer. Cancer Immunol Immunother (2008) [Epub ahead of print]
27. Lederer J.A., Prez V.L., DesRoches L., Kim M., Abbas A.K., and Lichtman A.H. Cytokine transcriptional events during helper T cell subset differentiation. J Exp Med 184 (1996) 397-406
28. + T cells. J Neuroimmunol 139 (2003) 102-108
29. Rayman P., Wesa A.K., Richmond A.L., et al. Effect of renalce llca rcinomas on the development of type 1 T-cell responses. Clin Cancer Res 10 (2004) 6360-6365
30. Wall L., Burke F., Barton C., Smyth J., and Balkwil L.F. IFN-γ induces apoptosis in ovarian cancer cells in vivo and in vitro. Clin Cancer Res 9 (2003) 2487-2496
31. Herskind C., Fleckenstein K., Lohr J., Li C.Y., Wenz F., and Lohr F. Antitumoralac tion of interferons and interleukins in combinationwith radiotherapy. Part I. Immunologic basis. Strahlenther Onkol 180 (2004) 187-193
32. Chen M.L., Pittet M.J., Gorelik L., et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo. Proc Natl Acad Sci USA 102 (2005) 419-424
33. Gately M.K., Renzetti L.M., Magram J., et al. The interleukin-12/interleukin-12 receptor system: Role in normal and pathogenic immune responses. Annu Rev Immunol 16 (1998) 495-521
34. Carter L.L., and Murphy K.M. Lineage-specific requirement for signal transducer and activator of transcription (Stat) 4 in interferon gamma production from CD4(+) versus CD8(+) T cells. J Exp Med 189 (1999) 1355-1360
35. Murray P.J. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr Opin Pharmacol 6 (2006) 379-386
36. Bose A., Ghosh D., Pal S., Mukherjee K., Biswas J., and Baral R.N. Interferonα2b augments suppressed immune functions in tobacco related head and neck squamous cell carcinoma patients by modulating cytokine signaling. Oral Oncol 42 (2006) 161-171