Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L-mediated endogenous production of interleukin-12

Human Immunology

Volumn 68, Issue 10, 2007, Pages 823-831

  Bose, Anamika ^a   Baral, Rathindranath ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

Author keywords

CD40 CD40L; Cytotoxicity; Interleukin 12; Natural killer cells; Neem leaf preparation

Indexed keywords

CD14 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD56 ANTIGEN; CONCANAMYCIN A; INTERLEUKIN 12; MITOGEN ACTIVATED PROTEIN KINASE P38;

ARTICLE; AZADIRACHTA INDICA; CELL STIMULATION; CYTOKINE RELEASE; CYTOTOXICITY; DOWN REGULATION; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PLANT LEAF; PRIORITY JOURNAL; PROTEIN INTERACTION; TUMOR CELL; UPREGULATION;

ADULT; ANTIGENS, CD40; ANTIGENS, CD56; AZADIRACHTA; CARCINOMA, SQUAMOUS CELL; CD40 LIGAND; CELL COUNT; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; INTERLEUKIN-12; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; PHYTOTHERAPY; PLANT LEAVES; PLANT PREPARATIONS; UP-REGULATION;

EID: 35349030382     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2007.08.002     Document Type: Article

References (29)

1. Biron C., Naguyen K.B., Pien G.C., Cousen L.P., and Salazar-Mather T. Natural killer cells in antiviral defence: Function and regulation by innate cytokines. Annu Rev Immunol 17 (1999) 189
2. Scharton-Kesten T.M., and Sher A. Role of natural killer cells in innate resistence to protozoan infections. Curr Opin Immunol 9 (1997) 44
3. Kiessling R., Klein E., and Wigzell H. Natural killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol 5 (1975) 112
4. Kagi D., Ledermann E., Burki K., Zinkernagel R.M., and Hengartner. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 14 (1996) 207
5. Moretta L., Bottino C., Pende D., Mingari M.C., Biassoni R., and Moretta A. Human natural killer cells: Their origin, receptors and function. Eur J Immunol 32 (2002) 1205
6. Cleveland M.G., Gorham J.D., Murphy T.L., Tuomanen E., and Murphy K.M. Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect Immuun 64 (1996) 1906
7. + T cells. J Immunol 154 (1995) 5071
8. Varker K.A., Terrell C.E., Welt M., Suleiman S., Thornton L., Anderson B.L., and Carson W.E. Impaired natural killer cell lysis in breast cancer patients with high levels of psychological stress is associated with altered expression of killer immunoglobin-like receptors. J Surg Res 139 (2007) 36
9. Hidaka T., Akada S., Teranishi A., Morikawa H., Sato S., Yoshida Y., et al. NK by Th1/Th2 Mirimostim (macrophage colony-stimulating factor; M-CSF) improves chemotherapy-induced impaired natural killer cell activity, Th1/Th2 balance, and granulocyte function. Cancer Sci 94 (2003) 814
10. Trinchieri G. Interleukin-12: A cytokine produced by antigen presenting cells with immunoregulatory functions in the generation of T-helper cells type-1 and cytotoxic lymphocytes. Blood 84 (1994) 4008
11. Mathur R.K., Awasthi A., and Saha B. Conundrum of CD40 function: Host protection or disease promotion?. Trends Parasitol 22 (2006) 117
12. Baral R.N., and Chattopadhyay U. Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma. Int Immunopharmacol 4 (2004) 355
13. Haque E., Mandal I., Pal S., and Baral R.N. Prophylactic dose of neem (Azadirachta indica) leaf preparation restricting murine tumor growth is nontoxic, hematostimulatory and immunostimulatory. Immunopharmacol Immunotoxicol 28 (2006) 33
14. Baral R.N., Mandal I., and Chattopadhyay U. Immunostimulatory neem leaf preparation acts as an adjuvant to enhance the efficacy of poorly immunogenic B16 melanoma surface antigen vaccine. Int Immunopharmacol 5 (2005) 1343
15. Ghosh D., Bose A., Haque E., and Baral R.N. Pretreatment with neem (Azadirachta indica) leaf preparation in Swiss mice diminishes leukopenia and enhances anti-tumor activity of cyclophosphamide. Phytother Res 20 (2006) 814
16. Mandal-Ghosh I., Chattopadhyay U., and Baral R.N. Neem leaf preparation enhances Th1 type immune response and anti-tumor immunity against breast tumor associated antigen. Cancer Immun 7 (2007) 8
17. Sarkar K., Bose A., Laskar S., Chaudhuri S.K., Dey S., Roychoudhuri P.K., and Baral R.N. Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. Int Immunopharmacol 7 (2007) 306
18. Haque E., and Baral R.N. Neem (Azadirachta indica) leaf preparation induces prophylactic growth inhibition of murine Ehrlich carcinoma in Swiss and C57BL/6 by activation of NK cells and NK-T cells. Immunobiology 211 (2006) 721
19. Cooper M.A., Fehniger T.A., and Caligiuri M.A. The biology of human natural killer subsets. Trends Immnol 22 (2001) 633
20. Lanier L.L., Le A.M., Civin C.I., Loken M.R., and Phillips J.H. The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immnol 136 (1986) 4480
21. Barry M., and Bleackley R.C. Cytotoxic T lymphocytes: All roads lead to death. Nat Rev Immnol 2 (2002) 401
22. Raja S.M., Wang B., Dantuluri M., Deshai U.R., Demiler B., Spiegel K., et al. Cytotoxic cell granule mediated apoptosis: Characterization of the macromoleculer complex of granzyme B with serglycine. J Biol Chem 277 (2002) 49523
23. Arjona A., Boyadjieva N., and Sarkar D.K. Circadian rhythms of granzymes B, perforin, IFNg and NK cell cytolytic activity in the spleen: Effects of chronic ethanol. J Immnol 172 (2004) 2811
24. Mu J., Zou Z.P., Yamamoto N., et al. Administration of recombinant interleulin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes. Cancer Res 55 (1995) 4404
25. Zou Z.P., Yamamoto N., Fugii T., et al. Systemic administration of rIL-12 induces complete tumor regression and protective immunity; response is correlated with a striking reversal of suppressed IFN-ã production by antitumor T cells. Int Immnol 7 (1995) 1135
26. Kilinic M.O., Aulakh K.S., Nair R.E., Jones S.A., Alard P., Kosiewicz M.M., and Egilmez N.K. Reversing tumor immune suppression with intratumoral IL-12: Activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8+ T effectors. J Immnol 177 (2006) 6962
27. Watkins S.K., Egilmez N.K., Suttles J., and Stout R.D. IL-12 rapidly alters the functional profile of tumor associated and tumor infiltrating macrophages in vitro and in vivo. J Immnol 178 (2007) 1357
28. Hashimoto W., Osaki T., Okamura H., Robbins P.D., Kurimoto M., Nagata S., et al. differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand and perforin-induced tumor apoptosis, respectively. J Immunol 163 (1999) 583
29. Mackey M.F., Gunn J.R., Ting P.P., Kikutani Hdranoff G., Noelle R.J., and Barth Jr. R.J. Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154. Cancer Res 57 (1997) 2569