Neem leaf preparation enhances Th1 type immune response and anti-tumor immunity against breast tumor associated antigen

Cancer Immunity

Volumn 7, Issue , 2007, Pages

  Mandal Ghosh, Ishita ^a   Chattopadhyay, Utpala ^a,b   Baral, Rathindranath ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

^b UNIVERSITY OF CALCUTTA   (India)

Author keywords

BTAA; Humoral immunity; Mice; Neem leaf preparation; Vaccination

Indexed keywords

AZADIRACHTA INDICA EXTRACT; BREAST TUMOR ASSOCIATED ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; TUMOR VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; AZADIRACHTA INDICA; BREAST TUMOR; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG MECHANISM; DRUG POTENTIATION; IMMUNE RESPONSE; MONOTHERAPY; MOUSE; NONHUMAN; RAT; TH1 CELL; TUMOR IMMUNITY;

EID: 34047178924     PISSN: None     EISSN: 14249634     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Pal S, Sanyal U, Chattopadhyay U. Purification and characterization of a new 85-kda glycoprotein antigen from human breast tumor. Int J Cancer 1995; 60: 759-765.
2. Chattopadhyay U, Pal S. A new 85 kDa breast tumor associated antigen - a potential diagnostic and prognostic agent. J Biosc 1997; 22: 69-75.
3. Stevanovic S. Identification of tumor associated T-cell epitopes for vaccine development. Nat Rev Cancer 2002; 2: 514-520.
4. Kensil CR, Patel U, Lennick M, Marciani D. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J Immunol 1991; 146: 431-437.
5. Kawarada Y, Ganss R, Garbi N, Sacher T, Arnold B, Hammerling GJ. NK- and CD8(+) T cell mediated eradication of established tumors by peritumoral injection of CpG-containing oligodeoxynucleotides. J Immunol 2001; 167: 5247-5253.
6. Lipford GB, Bauer M, Blank C, Reiter R, Wagner H, Heeg K. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen - a new class of vaccine adjuvants. Eur J Immunol 1997; 27: 2340-2344.
7. Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci USA 1996; 93: 2879-2883.
8. Weiner GJ, Liu HM, Wooldridge JE, Dahle CE, Krieg AM. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sci USA 1997; 94: 10833-10837.
9. Biswas K, Chattopadhyay I, Banerjee RK, Bandopadhyay U. Biological activities and medicinal properties of neem (Azadirachta Indica). Curr Sci 2002; 82: 1336-1345.
10. Upadhyay SN, Dhawan S, Garg S, Talwar GP. Immunomodulatory effects of neem (Azardirachta Indica) oil. Int J Immunopharmacol 1992; 14: 1187-1193.
11. Sadekar RD, Kolte AY, Barmase BS, Desai VF. Immunopotentiating effects of Azardirachta Indica (neem) dry leaves powder in broilers, naturally infected with IBD virus. Indian J Exp Biol 1998; 36: 1151-1153.
12. Ray A, Banerjee BD, Sen P. Modulation of humoral and cell mediated immune responses by Azardirachta Indica (neem) in mice. Indian J Exp Biol 1996; 34: 698-701.
13. Haque E, Mandal I, Pal S, Baral RN. Prophylactic dose of neem (Azadirachta indica) leaf preparation restricting murine tumor growth is nontoxic, hematostimulatory and immunostimulatory. Immunopharmacol Immunotoxicol 2006; 28: 33-50.
14. Baral RN, Chattopadhyay U. Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma. Int Immunopharmacol 2004; 4: 355-366.
15. Haque E, Baral RN. Neem (Azadirachta indica) leaf preparation induces prophylactic growth inhibition of murine Ehrlich carcinoma in Swiss and C57BL/6 by activation of NK cells and NK-T cells. Immunobiology 2006; 211: 721-731.
16. Bose A, Ghosh D, Pal S, Chaudhuri S, Baral RN. Neem leaf preparation enhances in vitro cytotoxic efficacy of peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients by modulating cytokine signaling pathway [abstract]. Indian J Med Res (Suppl) 2005; 121: 60.
17. Ghosh D, Bose A, Haque E, Baral RN. Pretreatment with neem (Azadirachta indica) leaf preparation in Swiss mice diminishes leukopenia and enhances anti-tumor activity of cyclophosphamide. Phytother Res 2006; 20: 814-818.
18. Gilewski T, Adluri S, Ragupathi G, Zhang S, Yao TJ, Panageas K, Moynahan M, Houghton A, Norton L, Livingston PO. Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21. Clin Cancer Res 2000; 6: 1693-1701.
19. Foon KA, Lutzky J, Baral RN, Yannelli JR, Hutchins L, Teitelbaum A, Kashala OL, Das R, Garrison J, Reisfeld RA, Bhattacharya-Chatterjee M. Clinical and Immune responses in advanced melanoma patients immunized with an anti-idiotype (ID) antibody mimicking disialoganglioside GD2. J Clin Oncol 2000; 18: 376-384.
20. Audibert FM, Lise LD. Adjuvants: current status, clinical perspectives and future prospects. Immunol Today 1993; 14: 281-284.
21. Sen G, Chakraborty M, Foon KA, Reisfeld RA, Bhattacharya-Chatterjee M. Induction of IgG antibodies by an anti-idiotype antibody mimicking disialoganglioside GD2. J Immunother 1998; 21: 75-83.
22. Baral RN. Tumor vaccine: current trends in antigen specific immunotherapy. Indian J Exp Biol 2005; 43: 389-406.
23. Livingston PO, Wong GYC, Adluri S, Tao Y, Padavan M, Parente R, Hanlon C, Jones Calves M, Helling F, Ritter G, Oettgen HF, Old LJ. Improved survival in stage III melanoma patients with GM2 antibodies: A randomized trial of adjuvant vaccination with GM2 ganglioside. J Clin Oncol 1994; 12: 1036-1044.
24. Corral RS, Petray PB. CpG DNA as a Th1-promoting adjuvant in immunization against Trypanosoma cruzi. Vaccine 2000; 19: 234-242.
25. Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 1997; 186: 1623-1631.
26. Dredge K, Marriott JB, Todryk SM, Dalgleish AG. Adjuvants and the promotion of Th1-type cytokines in tumor immunotherapy. Cancer Immunol Immunother 2002; 51: 521-531.
27. Thatte U, Dahanukar S. Rasayana Concept: clues from immunomodulatory therapy. In: Immunomodulation Upadhyay SN. Ed. New Delhi: Narosa Publising House; 1997; 141.
28. Collins JT, Dunnick WA. Germline transcripts of the murine immunoglobulin gamma 2a gene: structure and induction by IFNgamma. Int Immunol 1993; 5: 885-891.
29. Sarkar K, Bose A, Laskar S, Chaudhuri SK, Dey S, Roychoudhuri PK, Baral RN. Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. Int Immunopharmacol 2007; 7: 306-312.
30. Nair N, Mahajan S, Chawda R, Kandaswami C, Shanahan TC, Schwartz SA. Grape seed extract activates Th1 cells in vitro. Clin Diagn Lab Immunol 2002; 9: 470-476.
31. Nair MP, Kandaswami C, Mahajan S, Chadha KC, Chawda R, Nair H, Kumar N, Nair RE, Schwartz SA. The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta 2002; 1593: 29-36.
32. Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-gamma. Annu Rev Immunol 1997; 15: 749-795.
33. Puri HS. Neem: the devine tree: Azadirachta indica. Amsterdam: Harwood Academic Publishers; 1999.
34. Baral RN, Sherrat A, Das R, Foon KA, Bhattacharya-Chatterjee M. Murine monoclonal anti-idiotypic antibody as a surrogate antigen for human HER-2/Neu. Int J Cancer 2001; 92: 88-95.