(5R)-5-hydroxytriptolide inhibits the immune response of human peripheral blood mononuclear cells

International Immunopharmacology

Volumn 9, Issue 1, 2009, Pages 63-69

  Zhou, Ru ^a   Tang, Wei ^a   He, Pei Lan ^a   Yang, Yi Fu ^a   Li, Yuan Chao ^a   Zuo, Jian Ping ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

(5R) 5 hydroxytriptolide; Cytokine; MAPK; PBMC

Indexed keywords

5 HYDROXYTRIPTOLIDE; B7 ANTIGEN; CD40 LIGAND; CD69 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOTOXICITY; MIXED LYMPHOCYTE REACTION; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING;

ANTIGEN-PRESENTING CELLS; BLOTTING, WESTERN; CELL PROLIFERATION; CYTOKINES; DITERPENES; FLOW CYTOMETRY; GENES, MHC CLASS I; GENES, MHC CLASS II; HUMANS; IMMUNITY, CELLULAR; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TETRAZOLIUM SALTS; THIAZOLES;

EID: 58149461665     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.09.014     Document Type: Article

References (31)

1. Hamerman J.A., Ogasawara K., and Lanier L.L. NK cells in innate immunity. Curr Opin Immunol 17 (2005) 29-35
2. Brander C., Matter-Reissmann U.B., Jones N.G., Walker B.D., Sachs D.H., and Seebach J.D. Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride. J Immunol Methods 252 (2001) 1-14
3. Guermonprez P., Valladeau J., Zitvogel L., Thery C., and Amigorena S. Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol 20 (2002) 621-667
4. Zou J.P., Morford L.A., Chougnet C., Dix A.R., Brooks A.G., Torres N., et al. Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers. J Immunol 162 (1999) 4882-4892
5. Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 6824 (2001) 37-40
6. Ip Y.T., and Davis R.J. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr Opin Cell Biol 10 2 (1998) 205-219
7. Yamashita M., Kimura M., Kubo M., Shimizu C., Tada T., Perlmutter R.M., et al. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc Natl Acad Sci U S A 96 3 (1999) 1024-1029
8. Dong C., Davis R.J., and Flavell R.A. MAP kinases in the immune response. Annu Rev Immunol Annu Rev Immunol 20 (2002) 55-72
9. Rincón M., and Pedraza-Alva G. JNK and p38 MAP kinases in CD4+ and CD8+ T cells. Immunol Rev 192 (2003) 131-142
10. Karin M., and Gallagher E. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life 57 4-5 (2005) 283-295
11. Zhou R., Zhang F., He P.L., Zhou W.L., Wu Q.L., Xu J.Y., et al. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo. Int Immunopharmacol 5 13-14 (2005) 1895-1903
12. Tang W., Zhou R., Yang Y., Li Y.C., Yang Y.F., and Zuo J.P. Suppression of (5R)-5-hydroxytriptolide (LLDT-8) on allograft rejection in full MHC-mismatched mouse cardiac transplantation. Transplantation 81 6 (2006) 927-933
13. Tang W., Yang Y., Zhang F., Li Y.C., Zhou R., Wang J.X., et al. Prevention of graft-versus-host disease by a novel immunosuppressant, (5R)-5-hydroxytriptolide (LLDT-8), through expansion of regulatory T cells. Int Immunopharmacol 5 13-14 (2005) 1904-1913
14. Zhou R., Tang W., Ren Y.X., He P.L., Zhang F., Shi L.P., et al. (5R)-5-hydroxytriptolide attenuated collagen-induced arthritis in DBA/1 mice via suppressing interferon-gamma production and its related signaling. J Pharmacol Exp Ther 318 1 (2006) 35-44
15. Zhou R., Tang W., Ren Y.X., He P.L., Yang Y.F., Li Y.C., et al. Preventive effects of (5R)-5-hydroxytriptolide on concanavalin A-induced hepatitis. Eur J Pharmacol 537 1-3 (2006) 181-189
16. Fu Y.F., Zhu Y.N., Ni J., Zhong X.G., Tang W., Zhou R., et al. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation. J Neuroimmunol 175 1-2 (2006) 142-151
17. Ren Y.X., Zhou R., Tang W., Wang W.H., Li Y.C., Yang Y.F., and Zuo J.P. (5R)-5-hydroxytriptolide (LLDT-8) protects against bleomycin-induced lung fibrosis in mice. Acta Pharmacol Sin 28 4 (2007) 518-525
18. Zhou R., Wang J.X., Tang W., He P.L., Yang Y.F., Li Y.C., et al. (5R)-5-hydroxytriptolide inhibits IFN-gamma-related signaling. Acta Pharmacol Sin 27 12 (2006) 1616-1621
19. Zhou R., Zheng S.X., Tang W., He P.L., Li X.Y., Yang Y.F., et al. Inhibition of inducible nitric-oxide synthase expression by (5R)-5-hydroxytriptolide in interferon-gamma- and bacterial lipopolysaccharide-stimulated macrophages. J Pharmacol Exp Ther 316 1 (2006) 121-128
20. Matzinger P. The JAM test. A simple assay for DNA fragmentation and cell death. J Immunol Methods 145 1-2 (1991) 185-192
21. Papasavvas E., Sun J., Luo Q., Moore E.C., Thiel B., MacGregor R.R., et al. IL-13 acutely augments HIV-specific and recall responses from HIV-1-infected subjects in vitro by modulating monocytes. J Immunol 175 8 (2005) 5532-5540
22. Chomarat P., Rissoan M.C., Banchereau J., and Miossec P. Interferon gamma inhibits interleukin 10 production by monocytes. J Exp Med 177 2 (1993) 523-527
23. Bottino C., Moretta L., Pende D., Vitale M., and Moretta A. Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells. Mol Immunol 41 6-7 (2004) 569-575
24. Harada H., Saijo K., Watanabe S., Tsuboi K., Nose T., Ishiwata I., and Ohno T. Selective expansion of human natural killer cells from peripheral blood mononuclear cells by the cell line, HFWT. Jpn J Cancer Res 93 3 (2002) 313-319
25. Chilson O.P., and Kelly-Chilson A.E. Mitogenic lectins bind to the antigen receptor on human lymphocytes. Eur J Immunol 19 2 (1989) 389-396
26. Liu C.P., Tsai W.J., Lin Y.L., Liao J.F., Chen C.F., and Kuo Y.C. The extracts from Nelumbo Nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells. Life Sci 75 6 (2004) 699-716
27. Manning A.M., and Davis R.J. Targeting JNK for therapeutic benefit: from junk to gold?. Nat Rev Drug Discov 2 7 (2003) 554-565
28. Yang D.D., Conze D., Whitmarsh A.J., Barrett T., Davis R.J., Rincón M., et al. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 9 4 (1998) 575-585
29. Dong C., Davis R.J., and Flavell R.A. Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase. J Clin Immunol 21 4 (2001) 253-257
30. Lu H.T., Yang D.D., Wysk M., Gatti E., Mellman I., Davis R.J., et al. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J 18 7 (1999) 1845-1857
31. Rincón M., Enslen H., Raingeaud J., Recht M., Zapton T., Su M.S., et al. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J 17 10 (1998) 2817-2829