메뉴 건너뛰기




Volumn 14, Issue 28, 2008, Pages 2983-2998

Imaging of EGFR and EGFR tyrosine kinase overexpression in tumors by nuclear medicine modalities

Author keywords

Cancer; Cetuximab; EGFR; Gefitinib; Imaging; PET; Tyrosine kinase

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; BEVACIZUMAB; CANERTINIB; CETUXIMAB; COMPLEMENT; COPPER 64; DEFEROXAMINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ERLOTINIB; GEFITINIB; IMATINIB; INDIUM 111; IODINE 125; LAPATINIB; LUTETIUM 177; MATUZUMAB; MONOCLONAL ANTIBODY; PANITUMUMAB; PELITINIB; PENTETIC ACID; PROTEIN TYROSINE KINASE; SEMAXANIB; SUNITINIB; TRASTUZUMAB; UNINDEXED DRUG; VATALANIB; YTTRIUM; ZIRCONIUM; ANTINEOPLASTIC AGENT; DIAGNOSTIC AGENT; PROTEIN KINASE INHIBITOR; RADIOPHARMACEUTICAL AGENT;

EID: 58149392589     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161208786404326     Document Type: Review
Times cited : (72)

References (119)
  • 2
    • 0033757346 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors as agents
    • Ciardiello F. Epidermal growth factor receptor tyrosine kinase inhibitors as agents. Drugs 2000; 60: 25-32.
    • (2000) Drugs , vol.60 , pp. 25-32
    • Ciardiello, F.1
  • 3
    • 35448970307 scopus 로고    scopus 로고
    • Growth factor receptor kinases in cancer
    • Renhowe PA. Growth factor receptor kinases in cancer. Ann Rep Med Chem 2001; 36: 109-18.
    • (2001) Ann Rep Med Chem , vol.36 , pp. 109-118
    • Renhowe, P.A.1
  • 4
    • 0033762484 scopus 로고    scopus 로고
    • The pursuit of optimal outcomes in cancer therapy in a new age of rationally designed target-based anticancer agents
    • Rowinsky EK. The pursuit of optimal outcomes in cancer therapy in a new age of rationally designed target-based anticancer agents. Drugs 2000; 1: 1-14.
    • (2000) Drugs , vol.1 , pp. 1-14
    • Rowinsky, E.K.1
  • 5
    • 33847696075 scopus 로고    scopus 로고
    • Receptor tyrosine kinases: Mechanisms of activation and signaling
    • Hubbard SR, Miller WT. Receptor tyrosine kinases: Mechanisms of activation and signaling. Curr Opin Cell Biol 2007; 19: 117-23.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 117-123
    • Hubbard, S.R.1    Miller, W.T.2
  • 6
    • 1242329830 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: A promising target in solid tumours
    • Laskin JJ, Sandler AB. Epidermal growth factor receptor: A promising target in solid tumours. Cancer Treat Rev 2004; 30: 1-17.
    • (2004) Cancer Treat Rev , vol.30 , pp. 1-17
    • Laskin, J.J.1    Sandler, A.B.2
  • 7
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer. Signaling mechanisms and therapeutic opportunities
    • Yarden Y. The EGFR family and its ligands in human cancer. Signaling mechanisms and therapeutic opportunities. Eur J Cancer 2001; 37(Suppl 4): S3-8.
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 8
    • 0036562025 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: A new target for anticancer therapy
    • Grünwald V, Hidalgo M. The epidermal growth factor receptor: A new target for anticancer therapy. Curr Probl Cancer 2002; 26: 114-64.
    • (2002) Curr Probl Cancer , vol.26 , pp. 114-164
    • Grünwald, V.1    Hidalgo, M.2
  • 10
    • 0038449116 scopus 로고    scopus 로고
    • EGF receptor as a therapeutic target
    • Levitzki A. EGF receptor as a therapeutic target. Lung Cancer 2003; 41: S9-14.
    • (2003) Lung Cancer , vol.41
    • Levitzki, A.1
  • 11
    • 0037296357 scopus 로고    scopus 로고
    • The epidermal growth factor receptor-tyrosine kinase: A promising therapeutic target in solid tumors
    • Ritter CA, Arteaga CL. The epidermal growth factor receptor-tyrosine kinase: A promising therapeutic target in solid tumors. Semin Oncol 2003; 30: 3-11.
    • (2003) Semin Oncol , vol.30 , pp. 3-11
    • Ritter, C.A.1    Arteaga, C.L.2
  • 12
    • 0034468132 scopus 로고    scopus 로고
    • Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
    • Stern DF. Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases. Breast Cancer Res 2000; 2: 176-83.
    • (2000) Breast Cancer Res , vol.2 , pp. 176-183
    • Stern, D.F.1
  • 14
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signaling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signaling. Nature 2001; 411: 355-65.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 15
    • 33746347333 scopus 로고    scopus 로고
    • Tyrphostins and other tyrosine kinase inhibitors
    • Levitzki A, Mishani E. Tyrphostins and other tyrosine kinase inhibitors. Ann Rev Biochem 2006; 75: 93-109.
    • (2006) Ann Rev Biochem , vol.75 , pp. 93-109
    • Levitzki, A.1    Mishani, E.2
  • 16
    • 33744493376 scopus 로고    scopus 로고
    • Targeting tyrosine kinases in cancer: The second wave
    • Baselga J. Targeting tyrosine kinases in cancer: The second wave. Science 2006; 312: 1175-8.
    • (2006) Science , vol.312 , pp. 1175-1178
    • Baselga, J.1
  • 17
    • 0028352507 scopus 로고
    • Protein tyrosine kinases as therapeutic targets in cancer chemotherapy and recent advances in the development of new inhibitors
    • Fry DW. Protein tyrosine kinases as therapeutic targets in cancer chemotherapy and recent advances in the development of new inhibitors. Exp Opin Invest Drugs 1994; 3: 577-95.
    • (1994) Exp Opin Invest Drugs , vol.3 , pp. 577-595
    • Fry, D.W.1
  • 19
    • 39849105376 scopus 로고    scopus 로고
    • Growth factor receptors and related signaling pathways as targets for novel treatment strategies of hepatocellular cancer
    • Hopfner M, Schuppan D, Scherubl H. Growth factor receptors and related signaling pathways as targets for novel treatment strategies of hepatocellular cancer. World J Gastroenterol 2008; 14: 1-14.
    • (2008) World J Gastroenterol , vol.14 , pp. 1-14
    • Hopfner, M.1    Schuppan, D.2    Scherubl, H.3
  • 22
    • 36249003805 scopus 로고    scopus 로고
    • The HER family and cancer: Emerging molecular mechanisms and therapeutic targets
    • Sergina NV, Moasser MM. The HER family and cancer: Emerging molecular mechanisms and therapeutic targets. Trends Mol Med 2007; 13: 527-34
    • (2007) Trends Mol Med , vol.13 , pp. 527-534
    • Sergina, N.V.1    Moasser, M.M.2
  • 23
    • 0037665110 scopus 로고    scopus 로고
    • Protein kinase inhibitors as a therapeutic modality
    • Levitzki A. Protein kinase inhibitors as a therapeutic modality. Acc Chem Res 2003; 36: 462-9.
    • (2003) Acc Chem Res , vol.36 , pp. 462-469
    • Levitzki, A.1
  • 24
    • 0026458235 scopus 로고
    • Tyrphostins: Tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction
    • Levitzki A. Tyrphostins: Tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction. FASEB J 1992; 6: 3275-82.
    • (1992) FASEB J , vol.6 , pp. 3275-3282
    • Levitzki, A.1
  • 25
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki A, Gazit A. Tyrosine kinase inhibition: An approach to drug development. Science 1995; 267: 1782-8.
    • (1995) Science , vol.267 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 26
    • 33747855481 scopus 로고    scopus 로고
    • Comparing antibody and small-molecule therapies for cancer
    • Imai K, Takaoka A. Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 2006; 6: 714-27.
    • (2006) Nat Rev Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 27
    • 3042807464 scopus 로고    scopus 로고
    • Tyrosine kinase receptors as attractive targets for cancer therapy. Crit Rev
    • Bennasroune A, Gardin A, Aunis D, Cremel G, Hubert P. Tyrosine kinase receptors as attractive targets for cancer therapy. Crit Rev Oncol Hematol 2004; 50: 23-8.
    • (2004) Oncol Hematol , vol.50 , pp. 23-28
    • Bennasroune, A.1    Gardin, A.2    Aunis, D.3    Cremel, G.4    Hubert, P.5
  • 28
    • 1242338152 scopus 로고    scopus 로고
    • The HER receptor family: A rich target for therapeutic development
    • Mass RD. The HER receptor family: A rich target for therapeutic development. Int J Radiat Oncol Biol Phys 2004; 58: 932-40.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 932-940
    • Mass, R.D.1
  • 29
    • 25144517586 scopus 로고    scopus 로고
    • Evaluation of clinical outcomes according to HER2 detecton by fluorescence in situ hybridizationo in women with metastatic breast cancer treated with trastuzumab
    • Mass RD, Press MF, Anderson S, Cobleigh MA, Vogel CL, Dybdal N, et al. Evaluation of clinical outcomes according to HER2 detecton by fluorescence in situ hybridizationo in women with metastatic breast cancer treated with trastuzumab. Clin Breast Cancer 2005; 6: 240-6.
    • (2005) Clin Breast Cancer , vol.6 , pp. 240-246
    • Mass, R.D.1    Press, M.F.2    Anderson, S.3    Cobleigh, M.A.4    Vogel, C.L.5    Dybdal, N.6
  • 30
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N
    • Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-45.
    • (2004) Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 31
    • 33845365634 scopus 로고    scopus 로고
    • Cetuximab in the treatment of head and neck cancer
    • Bernier J. Cetuximab in the treatment of head and neck cancer. Expert Rev Anticancer Ther 2006; 6: 1539-52.
    • (2006) Expert Rev Anticancer Ther , vol.6 , pp. 1539-1552
    • Bernier, J.1
  • 32
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung KY, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A, et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005; 23: 1803-10.
    • (2005) J Clin Oncol , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3    Shah, M.4    Schwartz, G.K.5    Tse, A.6
  • 33
    • 33751083588 scopus 로고    scopus 로고
    • Panitumumab: In the treatment of metastatic colorectal cancer
    • Hoy SM, Wagstaff AJ. Panitumumab: In the treatment of metastatic colorectal cancer. Drugs 2006; 66: 2005-14.
    • (2006) Drugs , vol.66 , pp. 2005-2014
    • Hoy, S.M.1    Wagstaff, A.J.2
  • 34
    • 34247480064 scopus 로고    scopus 로고
    • Panitumumab with irinotecan/leucovorin/5-fluorouracil for first-line treatment of metastatic colorectal cancer
    • Berlin J, Posey J, Tchekmedyian S, Hu E, Chan D, Malik I, et al. Panitumumab with irinotecan/leucovorin/5-fluorouracil for first-line treatment of metastatic colorectal cancer. Clin Colorectal Cancer 2007; 6: 427-32.
    • (2007) Clin Colorectal Cancer , vol.6 , pp. 427-432
    • Berlin, J.1    Posey, J.2    Tchekmedyian, S.3    Hu, E.4    Chan, D.5    Malik, I.6
  • 35
    • 33845674883 scopus 로고    scopus 로고
    • Panitumumab the first fully human monoclonal antibody: From the bench to the clinic
    • Cohenuram M, Saif MW. Panitumumab the first fully human monoclonal antibody: From the bench to the clinic. Anticancer Drugs 2007; 18: 7-15.
    • (2007) Anticancer Drugs , vol.18 , pp. 7-15
    • Cohenuram, M.1    Saif, M.W.2
  • 36
    • 34248327817 scopus 로고    scopus 로고
    • Development and clinical indications of cetuximab
    • Labianca R, La Verde N, Garassino MC. Development and clinical indications of cetuximab. Int J Biol Markers 2007; 22(1 Suppl 4): S40-6.
    • (2007) Int J Biol Markers , vol.22 , Issue.1 SUPPL. 4
    • Labianca, R.1    La Verde, N.2    Garassino, M.C.3
  • 38
    • 0020027259 scopus 로고
    • Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells
    • Graziani Y, Chayoth R, Karny N, Feldman B, Levy J. Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells. Biochim Biophys Acta 1982; 714: 415-21.
    • (1982) Biochim Biophys Acta , vol.714 , pp. 415-421
    • Graziani, Y.1    Chayoth, R.2    Karny, N.3    Feldman, B.4    Levy, J.5
  • 39
    • 0020635362 scopus 로고
    • The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo
    • Graziani Y, Erikson E, Erikson RL. The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. Eur J Biochem 1983; 135: 583-9.
    • (1983) Eur J Biochem , vol.135 , pp. 583-589
    • Graziani, Y.1    Erikson, E.2    Erikson, R.L.3
  • 41
    • 0024947837 scopus 로고
    • Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus
    • Onoda T, Iinuma H, Sasaki Y, Hamada M, Isshiki K, Naganawa H, et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod 1989; 52: 1252-7.
    • (1989) J Nat Prod , vol.52 , pp. 1252-1257
    • Onoda, T.1    Iinuma, H.2    Sasaki, Y.3    Hamada, M.4    Isshiki, K.5    Naganawa, H.6
  • 42
    • 0022630086 scopus 로고
    • Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3
    • Umezawa H, Imoto M, Sawa T, Isshiki K, Matsuda N, Uchida T, et al. Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3. J Antibiot (Tokyo) 1986; 39: 170-3.
    • (1986) J Antibiot (Tokyo) , vol.39 , pp. 170-173
    • Umezawa, H.1    Imoto, M.2    Sawa, T.3    Isshiki, K.4    Matsuda, N.5    Uchida, T.6
  • 44
    • 0024240990 scopus 로고
    • Blocking of EGF-dependent cell proliferation of EGF receptor kinase inhibitors
    • Yaish P, Gazit A, Gilon C, Levitzki A. Blocking of EGF-dependent cell proliferation of EGF receptor kinase inhibitors. Science 1988; 242: 933-35.
    • (1988) Science , vol.242 , pp. 933-935
    • Yaish, P.1    Gazit, A.2    Gilon, C.3    Levitzki, A.4
  • 45
    • 0024434810 scopus 로고
    • Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors
    • Gazit A, Yaish P, Gilon C, Levitzki A. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 1989; 32: 2344-52.
    • (1989) J Med Chem , vol.32 , pp. 2344-2352
    • Gazit, A.1    Yaish, P.2    Gilon, C.3    Levitzki, A.4
  • 46
    • 0024520721 scopus 로고
    • Specific inhibitors of tyrosine-specific protein kinases: Properties of 4-hydroxycinnamamide derivatives in vitro
    • Shiraishi T, Owada MK, Tatsuka M, Yamashita T, Watanabe K, Kakunaga T. Specific inhibitors of tyrosine-specific protein kinases: Properties of 4-hydroxycinnamamide derivatives in vitro. Cancer Res 1989; 49: 2374-8.
    • (1989) Cancer Res , vol.49 , pp. 2374-2378
    • Shiraishi, T.1    Owada, M.K.2    Tatsuka, M.3    Yamashita, T.4    Watanabe, K.5    Kakunaga, T.6
  • 47
    • 0025361874 scopus 로고
    • A tyrosine-specific protein kinase inhibitor, alphacyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide, blocks the phosphorylation of tyrosine kinase substrate in intact cells
    • Shiraishi T, Owada MK, Tatsuka M, Fuse Y, Watanabe K, Kakunaga T. A tyrosine-specific protein kinase inhibitor, alphacyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide, blocks the phosphorylation of tyrosine kinase substrate in intact cells. Jpn J Cancer Res 1990 ; 81: 645-52.
    • (1990) Jpn J Cancer Res , vol.81 , pp. 645-652
    • Shiraishi, T.1    Owada, M.K.2    Tatsuka, M.3    Fuse, Y.4    Watanabe, K.5    Kakunaga, T.6
  • 48
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996; 2: 561-6.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3    Ohno, S.4    Segal, G.M.5    Fanning, S.6
  • 49
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1031-7.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3    Peng, B.4    Buchdunger, E.5    Ford, J.M.6
  • 50
    • 20044362947 scopus 로고    scopus 로고
    • State-of-the art therapy for gastrointestinal stromal tumors
    • Blanke CD, Corless CL. State-of-the art therapy for gastrointestinal stromal tumors. Cancer Invest 2005; 23: 274-80.
    • (2005) Cancer Invest , vol.23 , pp. 274-280
    • Blanke, C.D.1    Corless, C.L.2
  • 51
    • 18144401256 scopus 로고    scopus 로고
    • Both antiangiogeneis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584
    • Liu Y, Poon RT, Li Q, Kok TW, Lau C, Fan ST. Both antiangiogeneis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res 2005; 65: 3691-9.
    • (2005) Cancer Res , vol.65 , pp. 3691-3699
    • Liu, Y.1    Poon, R.T.2    Li, Q.3    Kok, T.W.4    Lau, C.5    Fan, S.T.6
  • 52
    • 33846621955 scopus 로고    scopus 로고
    • Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: An update of recent developments
    • Steeghs N, Nortier JW, Gelderblom H. Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: An update of recent developments. Ann Surg Oncol 2007; 14: 942-63.
    • (2007) Ann Surg Oncol , vol.14 , pp. 942-963
    • Steeghs, N.1    Nortier, J.W.2    Gelderblom, H.3
  • 53
    • 33748169241 scopus 로고    scopus 로고
    • Novel targeted approaches to treatment biliary tract cancer: The dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib
    • Wiedmann N, Feisthammal J, Bluthner T, Tannapfel A, Kamenz T, Kluge A, et al. Novel targeted approaches to treatment biliary tract cancer: The dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib. Anticancer Drugs 2006; 17: 783-95.
    • (2006) Anticancer Drugs , vol.17 , pp. 783-795
    • Wiedmann, N.1    Feisthammal, J.2    Bluthner, T.3    Tannapfel, A.4    Kamenz, T.5    Kluge, A.6
  • 54
    • 33750616807 scopus 로고    scopus 로고
    • A phase II study of sunitinib administered in a continuous daily regimen in patients with cytokine-refractory metastatic renal cell carcinoma
    • 223s
    • De Mulder PH, Roigas J, Gillessen S. A phase II study of sunitinib administered in a continuous daily regimen in patients with cytokine-refractory metastatic renal cell carcinoma. Proc Am Soc Clin Oncol 2006; 24: 223s.
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • De Mulder, P.H.1    Roigas, J.2    Gillessen, S.3
  • 55
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999; 59: 99-106.
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6
  • 56
    • 0003037701 scopus 로고    scopus 로고
    • A phase I/II study of SU5416 in combination with 5-FU/leucovorin in patients with metastatic colorectal cancer
    • Rosen P, Amado R, Hecht J. A phase I/II study of SU5416 in combination with 5-FU/leucovorin in patients with metastatic colorectal cancer. Proc Ac Soc Clin Oncol 2000; 18: 5a.
    • (2000) Proc Ac Soc Clin Oncol , vol.18
    • Rosen, P.1    Amado, R.2    Hecht, J.3
  • 57
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • Wood JM, Bold G, Buchdunger E, Cozens R, Ferrari S, Frei J, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000; 60: 2178-89.
    • (2000) Cancer Res , vol.60 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3    Cozens, R.4    Ferrari, S.5    Frei, J.6
  • 58
    • 0242637170 scopus 로고    scopus 로고
    • Targeting angiogenesis: A review of angiogenesis inhibitors in the treatment of lung cancer
    • Sridhar SS, Shepherd FA. Targeting angiogenesis: A review of angiogenesis inhibitors in the treatment of lung cancer. Lung Cancer 2003; 42: S81-91.
    • (2003) Lung Cancer , vol.42
    • Sridhar, S.S.1    Shepherd, F.A.2
  • 59
    • 0036252329 scopus 로고    scopus 로고
    • Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of a gastric cancer in a nude mouse model
    • Jung YD, Mansfield PF, Akagi M, Takeda A, Liu W, Bucana CD, et al. Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of a gastric cancer in a nude mouse model. Eur J Cancer 2002; 38: 1133-40.
    • (2002) Eur J Cancer , vol.38 , pp. 1133-1140
    • Jung, Y.D.1    Mansfield, P.F.2    Akagi, M.3    Takeda, A.4    Liu, W.5    Bucana, C.D.6
  • 60
    • 0033763084 scopus 로고
    • Iressa'), as an Anticancer Agent
    • Baselga J, Averbuch SD. ZD1839 ('Iressa'), as an Anticancer Agent. Drugs 2000; S1: 33-40.
    • (1839) Drugs 2000 , vol.S1 , pp. 33-40
    • Baselga, J.1    Averbuch, S.Z.2
  • 61
    • 0037667417 scopus 로고    scopus 로고
    • Preclinical studies with Erlotinib (Tarceva)
    • Akita RW, Sliwkowski MX. Preclinical studies with Erlotinib (Tarceva). Semin Oncol 2003; S7: 15-24.
    • (2003) Semin Oncol , vol.S7 , pp. 15-24
    • Akita, R.W.1    Sliwkowski, M.X.2
  • 62
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • Takano T, Ohe Y, Sakamoto H, Tsuta K, Matsuno Y, Tateishi U, et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005; 23: 6829-37.
    • (2005) J Clin Oncol , vol.23 , pp. 6829-6837
    • Takano, T.1    Ohe, Y.2    Sakamoto, H.3    Tsuta, K.4    Matsuno, Y.5    Tateishi, U.6
  • 63
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497-500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 64
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 66
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004; 101: 13306-11.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3    Doherty, J.4    Politi, K.5    Sarkaria, I.6
  • 67
    • 33846187218 scopus 로고    scopus 로고
    • Update on epidermal growth factor receptor mutations in non-small cell lung cancer
    • Riely GJ, Politi KA, Miller VA, Pao W. Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res 2006; 12: 7232-41.
    • (2006) Clin Cancer Res , vol.12 , pp. 7232-7241
    • Riely, G.J.1    Politi, K.A.2    Miller, V.A.3    Pao, W.4
  • 68
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005; 2: E73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 71
    • 33144464795 scopus 로고    scopus 로고
    • EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib
    • Yoshimura N, Kudoh S, Kimura T, Mitsuoka S, Matsuura K, Hirata K, et al. EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. Lung Cancer 2006; 51: 363-8.
    • (2006) Lung Cancer , vol.51 , pp. 363-368
    • Yoshimura, N.1    Kudoh, S.2    Kimura, T.3    Mitsuoka, S.4    Matsuura, K.5    Hirata, K.6
  • 72
    • 12144287534 scopus 로고    scopus 로고
    • United states food and drug administration drug approval summary: Gefitinib (ZD1839; Iressa) tablets
    • Cohen MH, Williams GA, Sridhara R, Chen G, McGuinn WD Jr, Morse D, et al. United states food and drug administration drug approval summary: gefitinib (ZD1839; Iressa) tablets. Clin Cancer Res 2004; 10: 1212-8.
    • (2004) Clin Cancer Res , vol.10 , pp. 1212-1218
    • Cohen, M.H.1    Williams, G.A.2    Sridhara, R.3    Chen, G.4    McGuinn Jr, W.D.5    Morse, D.6
  • 73
    • 33645051467 scopus 로고    scopus 로고
    • Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC
    • Maione P, Gridelli C, Troiani T, Ciardiello F. Combining targeted therapies and drugs with multiple targets in the treatment of NSCLC. Oncologist 2006; 11: 274-84.
    • (2006) Oncologist , vol.11 , pp. 274-284
    • Maione, P.1    Gridelli, C.2    Troiani, T.3    Ciardiello, F.4
  • 74
    • 36849056542 scopus 로고    scopus 로고
    • Multimodality imaging of the HER-kinase axis in cancer
    • Cai W, Niu G, Chen X. Multimodality imaging of the HER-kinase axis in cancer. Eur J Nucl Med Mol Imaging 2008; 35: 186-8.
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , pp. 186-188
    • Cai, W.1    Niu, G.2    Chen, X.3
  • 75
    • 22244439233 scopus 로고    scopus 로고
    • Radiolabeled peptides in oncology: Role in diagnosis and treatment
    • Weiner RE, Thakur ML. Radiolabeled peptides in oncology: Role in diagnosis and treatment. BioDrugs 2005; 19: 145-63.
    • (2005) BioDrugs , vol.19 , pp. 145-163
    • Weiner, R.E.1    Thakur, M.L.2
  • 76
    • 33746901230 scopus 로고    scopus 로고
    • Selecting lung cancer patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors by immunohistochemistry and fluorescence in situ hybridization
    • Dziadziuszko R, Hirsch FR, Varella-Garcia M, Bunn Jr PA. Selecting lung cancer patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors by immunohistochemistry and fluorescence in situ hybridization. Why, when, and how? Clin Cancer Res 2006; 12: S4409-15.
    • (2006) Why, when, and how? Clin Cancer Res , vol.12
    • Dziadziuszko, R.1    Hirsch, F.R.2    Varella-Garcia, M.3    Bunn Jr, P.A.4
  • 77
    • 36248944183 scopus 로고    scopus 로고
    • Cancer molecular imaging: Radionuclide-based biomarkers of the Epidermal Growth Factor Receptor (EGFR)
    • Mishani E, Abourbeh G. Cancer molecular imaging: Radionuclide-based biomarkers of the Epidermal Growth Factor Receptor (EGFR). Curr Topics Med Chem 2007; 7: 1755-72.
    • (2007) Curr Topics Med Chem , vol.7 , pp. 1755-1772
    • Mishani, E.1    Abourbeh, G.2
  • 78
    • 0024425936 scopus 로고
    • Imaging of human tumor xenografts with an indium-111-labeled anti-epidermal growth factor receptor monoconal antibody
    • Goldenberg A, Masui H, Divgi C, Kamrath H, Pentlow KS, Mendelsohn J. Imaging of human tumor xenografts with an indium-111-labeled anti-epidermal growth factor receptor monoconal antibody. J. Natl Cancer Inst 1989; 82: 1616-25.
    • (1989) J. Natl Cancer Inst , vol.82 , pp. 1616-1625
    • Goldenberg, A.1    Masui, H.2    Divgi, C.3    Kamrath, H.4    Pentlow, K.S.5    Mendelsohn, J.6
  • 79
    • 0034796350 scopus 로고    scopus 로고
    • Conjugation with 111In-DTPA-Poly(ethylene glycol) improves imaging of anti-EGF receptor antobody C225
    • Wen X, Wu Q, Ke S, Ellis L, Charnsangavej C, Delpassand AS, et al. Conjugation with 111In-DTPA-Poly(ethylene glycol) improves imaging of anti-EGF receptor antobody C225. J Nucl Med 2001; 42: 1530-7.
    • (2001) J Nucl Med , vol.42 , pp. 1530-1537
    • Wen, X.1    Wu, Q.2    Ke, S.3    Ellis, L.4    Charnsangavej, C.5    Delpassand, A.S.6
  • 80
    • 0027818836 scopus 로고
    • Blockage of epidermal growth factor receptor function by bivalent and monovalent fragments of C225 anti-epidermal growth factor receptor monoclonal antibodies
    • Fan Z, Masui H, Altas I, Mendelsohn J. Blockage of epidermal growth factor receptor function by bivalent and monovalent fragments of C225 anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 1993; 53: 4322-8.
    • (1993) Cancer Res , vol.53 , pp. 4322-4328
    • Fan, Z.1    Masui, H.2    Altas, I.3    Mendelsohn, J.4
  • 81
    • 33644827799 scopus 로고    scopus 로고
    • (89)Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals (90)Y and (177)Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab
    • Perk LR, Visser GW, Vosjan MJ, Stigter-van Walsum M, Tijink B M, Leemans CR, et al. (89)Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals (90)Y and (177)Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab. J Nucl Med 2005; 46: 1898-906.
    • (2005) J Nucl Med , vol.46 , pp. 1898-1906
    • Perk, L.R.1    Visser, G.W.2    Vosjan, M.J.3    Stigter-van Walsum, M.4    Tijink, B.M.5    Leemans, C.R.6
  • 82
    • 34249055896 scopus 로고    scopus 로고
    • Quantitative PET of EGFR expression in xenograft-bearing mice using (64)Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody
    • Cai W, Chen K, He L, Cao Q, Koong A, Chen X. Quantitative PET of EGFR expression in xenograft-bearing mice using (64)Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody. Eur J Nucl Med Mol Imaging 2007; 34: 850-8.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. 850-858
    • Cai, W.1    Chen, K.2    He, L.3    Cao, Q.4    Koong, A.5    Chen, X.6
  • 84
    • 34547830391 scopus 로고    scopus 로고
    • Cellular studies of binding, internalization and retention of a radiolabeled EGFR-binding affibody molecule
    • Nordberg E, Friedman M, Gostring L, Adams GP, Brismar H, Nilsson FY, et al. Cellular studies of binding, internalization and retention of a radiolabeled EGFR-binding affibody molecule. Nucl Med Biol 2007; 34: 609-18.
    • (2007) Nucl Med Biol , vol.34 , pp. 609-618
    • Nordberg, E.1    Friedman, M.2    Gostring, L.3    Adams, G.P.4    Brismar, H.5    Nilsson, F.Y.6
  • 85
    • 34347380371 scopus 로고    scopus 로고
    • Phage display selection of Affibody molecules with specific binding to the extracellular domain of the epidermal growth factor receptor
    • Friedman M, Nordberg E, Hoiden-Guthenberg I, Brismar H, Adams GP, Nilsson FY, et al. Phage display selection of Affibody molecules with specific binding to the extracellular domain of the epidermal growth factor receptor. Protein Eng Des Sel 2007; 20: 189-99.
    • (2007) Protein Eng Des Sel , vol.20 , pp. 189-199
    • Friedman, M.1    Nordberg, E.2    Hoiden-Guthenberg, I.3    Brismar, H.4    Adams, G.P.5    Nilsson, F.Y.6
  • 86
    • 43849098417 scopus 로고    scopus 로고
    • In vivo and in vitro uptake of 111In, delivered with the affibody molecule (ZEGFR: 955)2, in EGFR expressing tumour cells
    • Nordberg E, Orlova A, Friedman M, Tolmachev V, Stahl S, Nilsson FY, et al. In vivo and in vitro uptake of 111In, delivered with the affibody molecule (ZEGFR: 955)2, in EGFR expressing tumour cells. Oncol Rep 2008; 19: 853-7.
    • (2008) Oncol Rep , vol.19 , pp. 853-857
    • Nordberg, E.1    Orlova, A.2    Friedman, M.3    Tolmachev, V.4    Stahl, S.5    Nilsson, F.Y.6
  • 87
    • 39149087035 scopus 로고    scopus 로고
    • Directed evolution to low nanomolar affinity of a tumor-targeting epidermal growth factor receptor-binding affibody molecule
    • Friedman M, Orlova A, Johansson E, Eriksson TL, Hoiden-Guthenberg I, Tolmachev V, et al. Directed evolution to low nanomolar affinity of a tumor-targeting epidermal growth factor receptor-binding affibody molecule. J Mol Biol 2008; 376: 1388-402.
    • (2008) J Mol Biol , vol.376 , pp. 1388-1402
    • Friedman, M.1    Orlova, A.2    Johansson, E.3    Eriksson, T.L.4    Hoiden-Guthenberg, I.5    Tolmachev, V.6
  • 88
    • 0000283569 scopus 로고    scopus 로고
    • Synthesis and biodistribution of new C-11 and F-18 labeled epidermal growth factor receptor ligands
    • 141P
    • Mulholland GK, Zheng Q-H, Winkle WL, Carlson KA. Synthesis and biodistribution of new C-11 and F-18 labeled epidermal growth factor receptor ligands. J Nucl Med 1997; 38: 141P.
    • (1997) J Nucl Med , vol.38
    • Mulholland, G.K.1    Zheng, Q.-H.2    Winkle, W.L.3    Carlson, K.A.4
  • 90
    • 0001777761 scopus 로고
    • Radioiodinated epidermal growth factor receptor ligands as tumor probels. Dramatic potentiation of binding to MDA-468 cancer cells in presence of EGF
    • 71P
    • Mulholland GK, Winkle W, Mock BH, Sledge J. Radioiodinated epidermal growth factor receptor ligands as tumor probels. Dramatic potentiation of binding to MDA-468 cancer cells in presence of EGF. J Nucl Med 1995; 36: 71P.
    • (1995) J Nucl Med , vol.36
    • Mulholland, G.K.1    Winkle, W.2    Mock, B.H.3    Sledge, J.4
  • 91
    • 36249010594 scopus 로고    scopus 로고
    • Radioiodinated epidermal growth factor receptor inhibitors for tumor imaging with SPECT
    • Mattner F. Radioiodinated epidermal growth factor receptor inhibitors for tumor imaging with SPECT. Quart J Nucl Med 2001; 45: S6.
    • (2001) Quart J Nucl Med , vol.45
    • Mattner, F.1
  • 92
    • 27544486232 scopus 로고    scopus 로고
    • Fluorine-18 labeling of 6,7-disubstituted anilinoquinazoline derivatives for positron emission tomography (PET) imaging of tyrosine kinase receptors: Synthesis of 18F-Iressa and related molecular probes
    • Seimbille Y, Phelps ME, Czernin J, Silverman DHS. Fluorine-18 labeling of 6,7-disubstituted anilinoquinazoline derivatives for positron emission tomography (PET) imaging of tyrosine kinase receptors: synthesis of 18F-Iressa and related molecular probes. J Label Comp Radiopharm 2005; 48: 829-43.
    • (2005) J Label Comp Radiopharm , vol.48 , pp. 829-843
    • Seimbille, Y.1    Phelps, M.E.2    Czernin, J.3    Silverman, D.H.S.4
  • 94
    • 0035016290 scopus 로고    scopus 로고
    • Potential (18)F-labeled biomarkers for epidermal growth factor receptor tyrosine kinase
    • Bonasera TA, Ortu G, Rozen Y, Krais R, Freedman NM, Chisin R, et al. Potential (18)F-labeled biomarkers for epidermal growth factor receptor tyrosine kinase. Nucl Med Biol 2001; 28: 359-74.
    • (2001) Nucl Med Biol , vol.28 , pp. 359-374
    • Bonasera, T.A.1    Ortu, G.2    Rozen, Y.3    Krais, R.4    Freedman, N.M.5    Chisin, R.6
  • 96
    • 0027472437 scopus 로고
    • Consumption of EGF by A431 Cells: Evidence for receptor recycling
    • Masui H, Castro L, Mendelsohn J. Consumption of EGF by A431 Cells: Evidence for receptor recycling. J Cell Biol 1993; 120: 85-93.
    • (1993) J Cell Biol , vol.120 , pp. 85-93
    • Masui, H.1    Castro, L.2    Mendelsohn, J.3
  • 97
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • Yang XD, Jia XC, Corvalan JRF, Wang P, Davis CG. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol 2001; 38: 17-23.
    • (2001) Crit Rev Oncol Hematol , vol.38 , pp. 17-23
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.F.3    Wang, P.4    Davis, C.G.5
  • 98
    • 33748423744 scopus 로고    scopus 로고
    • 11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase
    • 11C]Iressa as a new potential PET cancer imaging agent for epidermal growth factor receptor tyrosine kinase. Bioorg Med Chem 2006; 16: 4102-6.
    • (2006) Bioorg Med Chem , vol.16 , pp. 4102-4106
    • Wang, J.-Q.1    Gao, M.2    Miller, K.D.3    Sledge, G.W.4    Zheng, Q.-H.5
  • 100
    • 43749125020 scopus 로고    scopus 로고
    • 18F]gefitinib as a molecular imaging probe for the assessment of the epidermal growth factor receptor status in malignant tumors
    • Epub ahead of print
    • 18F]gefitinib as a molecular imaging probe for the assessment of the epidermal growth factor receptor status in malignant tumors. Eur J Nucl Med Mol Imaging 2008; Epub ahead of print.
    • (2008) Eur J Nucl Med Mol Imaging
    • Su, H.1    Seimbille, Y.2    Ferl, G.Z.3    Bodenstein, C.4    Fueger, B.5    Kim, K.J.6
  • 101
    • 0002302620 scopus 로고    scopus 로고
    • Carbon -11 labeled irreversible inhibitor for mapping epidermal growth factor receptor tyrosine kinase (EGFR-TK)
    • Mishani E, Ben-David I, Rozen Y, Ortu G, Leviztki A. Carbon -11 labeled irreversible inhibitor for mapping epidermal growth factor receptor tyrosine kinase (EGFR-TK). J Label Cpd Radiopharm 2001; 44: S99-101.
    • (2001) J Label Cpd Radiopharm , vol.44
    • Mishani, E.1    Ben-David, I.2    Rozen, Y.3    Ortu, G.4    Leviztki, A.5
  • 102
    • 0036782104 scopus 로고    scopus 로고
    • Labeled EGFr-TK irreversible inhibitor (ML03). In vitro and in vivo properties, potential as PET biomarker for cancer and feasibility as anticancer drug
    • Ortu G, Ben-David I, Rozen Y, Freedman NM, Chisin R, Levitzki A, et al. Labeled EGFr-TK irreversible inhibitor (ML03). In vitro and in vivo properties, potential as PET biomarker for cancer and feasibility as anticancer drug. Int J Cancer 2002; 101: 360-70.
    • (2002) Int J Cancer , vol.101 , pp. 360-370
    • Ortu, G.1    Ben-David, I.2    Rozen, Y.3    Freedman, N.M.4    Chisin, R.5    Levitzki, A.6
  • 103
    • 0037318292 scopus 로고    scopus 로고
    • Radiosynthesis of ML03, a novel positron emission tomography biomarker for targeting epidermal growth factor receptor via the labeling synthon: [C-11]Acryloyl chloride
    • Ben-David I, Rozen Y, Ortu G, Mishani E. Radiosynthesis of ML03, a novel positron emission tomography biomarker for targeting epidermal growth factor receptor via the labeling synthon: [C-11]Acryloyl chloride. Appl Rad Isotop 2003; 58: 209-17.
    • (2003) Appl Rad Isotop , vol.58 , pp. 209-217
    • Ben-David, I.1    Rozen, Y.2    Ortu, G.3    Mishani, E.4
  • 104
    • 2942549775 scopus 로고    scopus 로고
    • Novel iodine-124 labeled EGFR inhibitors as potential PET agents for molecular imaging in cancer
    • Shaul M, Abourbeh G, Jacobson O, Rozen Y, Laky D, Levitzki A, et al. Novel iodine-124 labeled EGFR inhibitors as potential PET agents for molecular imaging in cancer. Bioorg Med Chem 2004; 12: 3421-9.
    • (2004) Bioorg Med Chem , vol.12 , pp. 3421-3429
    • Shaul, M.1    Abourbeh, G.2    Jacobson, O.3    Rozen, Y.4    Laky, D.5    Levitzki, A.6
  • 105
    • 1842850604 scopus 로고    scopus 로고
    • Novel carbon-11 labeled 4-dimethylamino-but-2-enoic acid [4-(phenylamino)-quinazoline-6-yl]amides: Potential PET bioprobes for molecular imaging of EGFR-positive tumors
    • Mishani E, Abourbeh G, Rozen Y, Jacobson O, Lacy D, Ben David I, et al. Novel carbon-11 labeled 4-dimethylamino-but-2-enoic acid [4-(phenylamino)-quinazoline-6-yl]amides: Potential PET bioprobes for molecular imaging of EGFR-positive tumors. Nucl Med Biol 2004; 31: 469-76.
    • (2004) Nucl Med Biol , vol.31 , pp. 469-476
    • Mishani, E.1    Abourbeh, G.2    Rozen, Y.3    Jacobson, O.4    Lacy, D.5    Ben David, I.6
  • 106
    • 23444462507 scopus 로고    scopus 로고
    • High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors
    • Mishani E, Abourbeh G, Jacobson O, Dissoki S, Ben Daniel R, Rozen Y, et al. High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors. J Med Chem 2005; 48: 5337-48.
    • (2005) J Med Chem , vol.48 , pp. 5337-5348
    • Mishani, E.1    Abourbeh, G.2    Jacobson, O.3    Dissoki, S.4    Ben Daniel, R.5    Rozen, Y.6
  • 107
    • 14644421627 scopus 로고    scopus 로고
    • Synthesis of 6-acrylamido-4-(2-[18F]fluoroanilino)quinazo-line: A prospective irreversible EGFR binding probe
    • Vasdev N, Dorff PN, Gibbs AR, Nandanan E, Reid LM, O'Neil JP, et al. Synthesis of 6-acrylamido-4-(2-[18F]fluoroanilino)quinazo-line: A prospective irreversible EGFR binding probe. J Labelled Comp Radiopharm 2005; 48: 109-15.
    • (2005) J Labelled Comp Radiopharm , vol.48 , pp. 109-115
    • Vasdev, N.1    Dorff, P.N.2    Gibbs, A.R.3    Nandanan, E.4    Reid, L.M.5    O'Neil, J.P.6
  • 108
    • 33745599854 scopus 로고    scopus 로고
    • Fluorine-18 labeling of ML04 - presently the most promising irreversible inhibitor candidate for visualization of EGFR in cancer
    • Dissoki S, Laky D, Mishani E. Fluorine-18 labeling of ML04 - presently the most promising irreversible inhibitor candidate for visualization of EGFR in cancer. J Labelled Comp Radiopharm 2006; 49: 533-43.
    • (2006) J Labelled Comp Radiopharm , vol.49 , pp. 533-543
    • Dissoki, S.1    Laky, D.2    Mishani, E.3
  • 109
    • 33845935326 scopus 로고    scopus 로고
    • Evaluation of radiolabeled ML04, a putative irreversible inhibitor of the epidermal growth factor receptor, as a bioprobe for pet imaging of EGFR overexpressing tumors
    • Abourbeh G, Dissoki S, Jacobson O, Litchi A, Ben Daniel R, Laki D, et al. Evaluation of radiolabeled ML04, a putative irreversible inhibitor of the epidermal growth factor receptor, as a bioprobe for pet imaging of EGFR overexpressing tumors. Nucl Med Bio 2007; 34: 55-70.
    • (2007) Nucl Med Bio , vol.34 , pp. 55-70
    • Abourbeh, G.1    Dissoki, S.2    Jacobson, O.3    Litchi, A.4    Ben Daniel, R.5    Laki, D.6
  • 110
    • 33748996814 scopus 로고    scopus 로고
    • Molecular imaging of EGFR kinase activity in tumors with 124I-labeled small molecular tracer and positron emission tomography
    • Pal A, Glekas A, Doubrovin M, Balatoni J, Beresten T, Maxwell D, et al. Molecular imaging of EGFR kinase activity in tumors with 124I-labeled small molecular tracer and positron emission tomography. Mol Imaging Biol 2006; 8: 262-77.
    • (2006) Mol Imaging Biol , vol.8 , pp. 262-277
    • Pal, A.1    Glekas, A.2    Doubrovin, M.3    Balatoni, J.4    Beresten, T.5    Maxwell, D.6
  • 111
    • 34548217626 scopus 로고    scopus 로고
    • 18F]-PEG group on tracer qualification of [4-(phenylamino)-quinazoline-6-yl]-amide moiety - an EGFR putative irreversible inhibitor
    • 18F]-PEG group on tracer qualification of [4-(phenylamino)-quinazoline-6-yl]-amide moiety - an EGFR putative irreversible inhibitor. Appl Rad Isotp 2007; 65: 1140-51.
    • (2007) Appl Rad Isotp , vol.65 , pp. 1140-1151
    • Dissoki, S.1    Aviv, Y.2    Laky, D.3    Abourbeh, G.4    Levitzki, A.5    Mishani, E.6
  • 112
    • 32944474782 scopus 로고    scopus 로고
    • Evaluation of N-{4-[(3 '-[F-18]fluoroethylphenyl) amino]-6-quinazolinyl}acrylamide ([F-18]FEQA), a labeled tyrosine kinase inhibitor, for imaging epidermal growth factor receptor density
    • 372P
    • Waldherr C, Satyamurthy N, Toyokuni T, Wang S, Mellinghoff I, Tran C, et al. Evaluation of N-{4-[(3 '-[F-18]fluoroethylphenyl) amino]-6-quinazolinyl}acrylamide ([F-18]FEQA), a labeled tyrosine kinase inhibitor, for imaging epidermal growth factor receptor density. J Nucl Med 2003; 44: 372P.
    • (2003) J Nucl Med , vol.44
    • Waldherr, C.1    Satyamurthy, N.2    Toyokuni, T.3    Wang, S.4    Mellinghoff, I.5    Tran, C.6
  • 113
    • 13144266690 scopus 로고    scopus 로고
    • Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor
    • Fry DW, Bridges AJ, Denny WA, Doherty A, Greis KD, Hicks JL, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci USA 1998; 95: 12022-7.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12022-12027
    • Fry, D.W.1    Bridges, A.J.2    Denny, W.A.3    Doherty, A.4    Greis, K.D.5    Hicks, J.L.6
  • 114
    • 0035253847 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor
    • Smaill JB, Showalter HD, Zhou H, Bridges AJ, McNamara DJ, Fry DW, et al. Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor. J Med Chem 2001; 44: 429-40.
    • (2001) J Med Chem , vol.44 , pp. 429-440
    • Smaill, J.B.1    Showalter, H.D.2    Zhou, H.3    Bridges, A.J.4    McNamara, D.J.5    Fry, D.W.6
  • 115
    • 0035899182 scopus 로고    scopus 로고
    • 6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity
    • Tsou HR, Mamuya N, Johnson BD, Reich MF, Gruber BC, Ye F, et al. 6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity. J Med Chem 2001; 44: 2719-34.
    • (2001) J Med Chem , vol.44 , pp. 2719-2734
    • Tsou, H.R.1    Mamuya, N.2    Johnson, B.D.3    Reich, M.F.4    Gruber, B.C.5    Ye, F.6
  • 116
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995; 19: 183-232.
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 117
    • 47049128631 scopus 로고    scopus 로고
    • Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer
    • Hamoudeh M, Kamleh MA, Diab R, Fessi H. Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer. Adv Drug Deliv Rev 2008; 60(12): 1329-46.
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.12 , pp. 1329-1346
    • Hamoudeh, M.1    Kamleh, M.A.2    Diab, R.3    Fessi, H.4
  • 118
    • 42149164854 scopus 로고    scopus 로고
    • Cancer-associated carbonic anhydrases and their inhibition
    • Pastorekova S, Zatovicova M, Pastorek J. Cancer-associated carbonic anhydrases and their inhibition. Curr Pharm Des 2008; 14(7): 685-98
    • (2008) Curr Pharm Des , vol.14 , Issue.7 , pp. 685-698
    • Pastorekova, S.1    Zatovicova, M.2    Pastorek, J.3
  • 119
    • 43449103949 scopus 로고    scopus 로고
    • Characterization of compound 584, an Abl kinase inhibitor with lasting effects
    • Puttini M, Redaelli S, Moretti L, Brussolo S, Gunby RH, Mologni L, et al. Characterization of compound 584, an Abl kinase inhibitor with lasting effects. Haematologica 2008; 93(5): 653-61.
    • (2008) Haematologica , vol.93 , Issue.5 , pp. 653-661
    • Puttini, M.1    Redaelli, S.2    Moretti, L.3    Brussolo, S.4    Gunby, R.H.5    Mologni, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.