Fluorine-18 labeling of 6,7-disubstituted anilinoquinazoline derivatives for positron emission tomography (PET) imaging of tyrosine kinase receptors: Synthesis of18F-Iressa and related molecular probes

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 48, Issue 11, 2005, Pages 829-843

  Seimbille, Yann ^a   Phelps, Michael E ^a   Czernin, Johannes ^a   Silverman, Daniel H S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

EGFR; Fluorine 18; Positron emission tomography; Tyrosine kinase inhibitors

Indexed keywords

AMINO ACIDS; ENZYME INHIBITION; FLUORINE; POSITRONS;

ANTINEOPLASTIC AGENTS; EGFR; ENZYMATIC ACTIVITIES; FLUORINE-18; LABELINGS; MOLECULAR PROBES; TOMOGRAPHY IMAGING; TYROSINE KINASE; TYROSINE KINASE INHIBITOR; TYROSINE-KINASE RECEPTORS;

POSITRON EMISSION TOMOGRAPHY;

3 CHLORO 4 TRIMETHYLAMMONIUM NITROBENZENE TRIFLUOROMETHANESULFONATE; 4 (3' CHLORO 4' FLUOROANILINO) 6 METHOXY 7 [(1 METHYLPIPERIDIN 4 YL)METHOXY] QUINAZOLINE; 4 (3' CHLORO 4' FLUOROANILINO) 6,7 BIS(2 METHOXYETHOXY) QUINAZOLINE; 4 (3' CHLORO 4' FLUOROANILINO) 7 METHOXY 6 (3 MORPHOLINOPROPOXY) QUINAZOLINE; 4 (3' CHLORO 4' [F 18]FLUOROANILINO) 6 METHOXY 7 [(1 METHYLPIPERIDIN 4 YL)METHOXY] QUINAZOLINE; 4 (3' CHLORO 4' [F 18]FLUOROANILINO) 6,7 BIS (2 METHOXYETHOXY) QUINAZOLINE; 4 (3' CHLORO 4' [F 18]FLUOROANILINO) 7 METHOXY 6 (3 MORPHOLINOPROPOXY) QUINAZOLINE; 4 CHLORO 6,7 BIS(2 METHOXYETHOXY) QUINAZOLINE; 6,7 ANILINOQUINAZOLINE; 6,7 BIS(2 METHOXYETHOXY) 3,4 DIHYDROQUINAZOLIN 4 ONE; 7 METHOXY 6 (3 MORPHOLINOPROPOXY) 3,4 DIHYDROQUINAZOLIN 4 ONE; ERLOTINIB; ETHYL 2 AMINO 4,5 BIS(2 METHOXYETHOXY) BENZOATE; ETHYL 3,4 BIS (2 METHOXYETHOXY) BENZOATE; FLUORINE 18; GEFITINIB; METHYL 3 (3 CHLOROPROPOXY) 4 METHOXYBENZOATE; METHYL 3 METHOXY 4 (1 METHYLPIPERIDIN 4 YLMETHOXY) BENZOATE; METHYL 4 METHOXY 5 (3 MORPHOLINOPROPOXY) 2 NITROBENZOATE; METHYL 5 (3 CHLOROPROPOXY) 4 METHOXY 2 NITROBENZOATE; QUINAZOLINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VANDETANIB;

ALKYLATION; ARTICLE; CATALYSIS; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGENATION; ISOTOPE LABELING; MOLECULAR PROBE; NITRATION; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; REDUCTION;

EID: 27544486232     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.998     Document Type: Article

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