Amphiregulin Overexpression Results in Rapidly Growing Keratinocytic Tumors: An In Vivo Xenograft Model of Keratoacanthoma

American Journal of Pathology

Volumn 163, Issue 6, 2003, Pages 2451-2458

  Billings, Steven D ^a   Southall, Michael D ^a   Li, Tao ^a   Cook, Paul W ^b   Baldridge, LeeAnn ^a   Moores, William B ^a   Spandau, Daniel F ^a   Foley, John G ^a   Travers, Jeffrey B ^a  

^a INDIANA UNIVERSITY   (United States)

^b Cascade Biologics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL CELL CARCINOMA; CARCINOGENESIS; CELL LINE; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KERATINOCYTE; KERATOACANTHOMA; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; TUMOR GROWTH; XENOGRAFT;

EID: 0344413006     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63600-0     Document Type: Article

References (26)

1. LeBoit PE: Can we understand keratoacanthoma? Am J Dermatopathol 2002, 24:166-168
2. Beham A, Regauer S, Soyer HP, Beham-Schmid C: Keratoacanthoma: a clinically distinct variant of well-differentiated squamous cell carcinoma. Adv Anat Pathol 1998, 5:269-280
3. Cribier B, Asch P, Grosshans E: Differentiating squamous cell carcinoma from keratoacanthoma using histopathological criteria: is it possible? A study of 296 cases. Dermatology 1999, 199:208-212
4. Tran TA, Ross JS, Boehm JR, Carlson JA: Comparison of mitotic cyclins and cyclin-dependent kinase expression in keratoacanthoma and squamous cell carcinoma. J Cutan Pathol 1999, 26:391-397
5. Tran TA, Ross JS, Sheehan CE, Carlson JA: Comparison of oncostatin M expression in keratoacanthoma and squamous cell carcinoma. Mod Pathol 2000, 13:427-432
6. Hodak E, Jones RE, Ackerman AB: Solitary keratoacanthoma is a squamous-cell carcinoma: three examples with metastases. Am J Dermatopathol 1993, 15:332-342; 343-352
7. Sanchez Yus E, Simon P, Requena L, Ambrojo P, de Eusebio E: Solitary keratoacanthoma: a self-healing proliferation that frequently becomes malignant. Am J Dermatopathol 2000, 22:305-310
8. Peng X, Griffith JW, Han R, Lang CM, Kreider JW: Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis. Am J Pathol 1999, 155:315-324
9. Piepkorn M, Pittelkow MR, Cook PW: Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidermal growth factor-related growth factors. J Invest Dermatol 1998, 111: 715-721
10. Shoyab M, McDonald VL, Bradley JG, Todaro GJ: Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci USA 1988, 85:6528-6532
11. Shoyab M, Plowman GD, McDonald VL, Bradley JG, Todaro GJ: Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science 1989, 243:1074-1076
12. Plowman GD, Green JM, McDonald VL, Neubauer MG, Disteche CM, Todaro GJ, Shoyab M: The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Mol Cell Biol 1990, 10:1969-1981
13. Brown CL, Meise KS, Plowman GD, Coffey RJ, Dempsey PJ: Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor: release of a predominant N-glycosylated 43-kDa soluble form. J Biol Chem 1998, 273:17258-17268
14. Garach-Jehoshua O, Ravid A, Liberman UA, Koren R: 1, 25-Dihydroxyvitamin D3 increases the growth-promoting activity of autocrine epidermal growth factor receptor ligands in keratinocytes. Endocrinology 1999, 140:713-721
15. Cook PW, Mattox PA, Keeble WW, Pittelkow MR, Plowman GD, Shoyab M, Adelman JP, Shipley GD: A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. Mol Cell Biol 1991, 11:2547-2557
16. Piepkorn M, Lo C, Plowman G: Amphiregulin-dependent proliferation of cultured human keratinocytes: autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans. J Cell Physiol 1994, 159:114-120
17. Cook PW, Pittelkow MR, Keeble WW, Graves-Deal R, Coffey Jr RJ, Shipley GD: Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res 1992, 52: 3224-3227
18. Piepkorn M: Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases. Am J Dermatopathol 1996, 18:165-171
19. Cook PW, Piepkorn M, Clegg CH, Plowman GD, DeMay JM, Brown JR, Pittelkow MR: Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest 1997, 100: 2286-2294
20. Dlugosz AA, Cheng C, Williams EK, Darwiche N, Dempsey PJ, Mann B, Dunn AR, Coffey Jr RJ, Yuspa SH: Autocrine transforming growth factor α is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands. Cancer Res 1995, 55:1883-1893
21. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988, 106:761-771
22. Spandau DF, Marques M, Bierhuizen M, Wagemaker G, Hurwitz S, Pei Y, Breese R, Travers JB: Use of enhanced green fluorescent protein to monitor retroviral-mediated gene therapy in human keratinocytes. Exp Dermatol 2000, 9:252-257
23. Pei Y, Barber LA, Murphy RC, Johnson CA, Kelley SW, Dy LC, Fertel RH, Nguyen TM, Williams DA, Travers JB: Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis. J Immunol 1998, 161:1954-1961
24. Sato S, Kume K, Ito C, Ishii S, Shimizu T: Accelerated proliferation of epidermal keratinocytes by the transgenic expression of the platelet-activating factor receptor. Arch Dermatol Res 1999, 291: 614-621
25. Finzi E, Kilkenny A, Strickland JE, Balaschak M, Bringman T, Derynck R, Aaronson S, Yuspa SH: TGF α stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression. Mol Carcinog 1988, 1:7-12
26. Nickoloff BJ: Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. Viewpoint J Cutan Pathol 2001, 28:57-64