Human Transcriptional Coactivator PC4 Stimulates DNA End Joining and Activates DSB Repair Activity

Journal of Molecular Biology

Volumn 385, Issue 3, 2009, Pages 788-799

  Batta, Kiran ^a   Yokokawa, Masatoshi ^b   Takeyasu, Kunio ^b   Kundu, Tapas K ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

atomic force microscopy; DSB repair; end joining; NHEJ; PC4

Indexed keywords

DNA; NUCLEAR PROTEIN; PC4 PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; STIMULATION;

EID: 58149196197     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.11.008     Document Type: Article

References (33)

1. Karran P. DNA double strand break repair in mammalian cells. Curr. Opin. Genet. Dev. 10 (2000) 144-150
2. Jackson S.P. Sensing and repairing DNA double-strand breaks. Carcinogenesis 23 (2002) 687-696
3. Haber J.E. Partners and pathways repairing a double-strand break. Trends Genet. 16 (2000) 259-264
4. Walker J.R., Corpina R.A., and Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412 (2001) 607-614
5. Doherty A.J., and Jackson S.P. DNA repair: how Ku makes ends meet. Curr. Biol. 11 (2001) 920-924
6. Ramsden D.A., and Gellert M. Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks. EMBO J. 17 (1998) 609-614
7. Cary R.B., Peterson S.R., Wang J., Bear D.G., Bradbury E.M., and Chen D.J. DNA looping by Ku and the DNA-dependent protein kinase. Proc. Natl Acad. Sci. USA 94 (1997) 4267-4272
8. Paull T.T., and Gellert M. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell 1 (1998) 969-979
9. Ma Y., Pannicke U., Schwarz K., and Lieber M.R. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and VDJ recombination. Cell 108 (2002) 781-794
10. Grawunder U., Wilm M., Wu X., Kulesza P., Wilson T.E., Mann M., and Lieber M.R. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388 (1997) 492-495
11. Burma S., Chen B.P., and Chen D.J. Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amsterdam) 5 (2006) 1042-1048
12. Khanna K.K., and Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27 (2001) 247-254
13. Ahnesorg P., Smith P., and Jackson S.P. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124 (2006) 301-313
14. Lu H., Pannicke U., Schwarz K., and Lieber M.R. Length-dependent binding of human XLF to DNA and stimulation of XRCC4:DNA ligase IV activity. J. Biol. Chem. 282 (2007) 11155-11162
15. Tsai C.J., Kim S.A., and Chu G. Cernunnos-XLF promotes the ligation of mismatched and noncohesive DNA ends. Proc. Natl Acad. Sci. USA 104 (2007) 7851-7856
16. Zha S., Alt F.W., Cheng H.L., Brush J.W., and Gang L. Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc. Natl Acad. Sci. USA 104 (2007) 4518-4523
17. Ge H., and Roeder R.G. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78 (1994) 513-523
18. Pan Z.Q., Ge H., Amin A.A., and Hurwitz J. Transcription-positive cofactor 4 forms complexes with HSSB (RPA) on single-stranded DNA and influences HSSB dependent enzymatic synthesis of simian virus 40 DNA. J. Biol. Chem. 271 (1996) 22111-22116
19. Das C., Hizume K., Batta K., Kumar B.R., Gadad S.S., Ganguly S., et al. Transcriptional coactivator PC4, a chromatin-associated protein, induces chromatin condensation. Mol. Cell. Biol. 26 (2006) 8303-8315
20. Wang J.Y., Sarker A.H., Cooper P.K., and Volkert M.R. The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damage. Mol. Cell. Biol. 24 (2004) 6084-6093
21. Batta K., and Kundu T.K. Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications. Mol. Cell. Biol. 27 (2007) 7603-7614
22. Banerjee S., Kumar B.R., and Kundu T.K. General transcriptional coactivator PC4 activates p53 function. Mol. Cell. Biol. 24 (2004) 2052-2062
23. Kannan P., and Tainsky M.A. Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interference. Mol. Cell. Biol. 19 (1999) 899-908
24. Kishore A.H., Batta K., Das C., Agarwal S., and Kundu T.K. p53 regulates its own activator: transcriptional co-activator PC4, a new p53-responsive gene. Biochem. J. 406 (2007) 437-444
25. Tang W., Willers H., and Powell S.N. p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res. 59 (1999) 2562-2565
26. Jayaraman L., Moorthy N.C., Murthy K.G., Manley J.L., Bustin M., and Prives C. High mobility group protein-1 (HMG-1) is a unique activator of p53. Genes Dev. 12 (1998) 462-472
27. McKinney K., and Prives C. Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein. Mol. Cell. Biol. 22 (2002) 6797-6808
28. Stros M., Cherny D., and Jovin T.M. HMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their ends. Eur. J. Biochem. 267 (2000) 4088-4097
29. Watanabe F., Shirakawa H., Yoshida M., Tsukada K., and Teraoka H. Stimulation of DNA-dependent protein kinase activity by high mobility group proteins 1 and 2. Biochem. Biophys. Res. Commun. 202 (1994) 736-742
30. Ollila J., and Vihinen M. Stimulation-induced gene expression in Ramos B-cells. Genes Immun. 4 (2003) 343-350
31. Stiff T., Shtivelman E., Jeggo P., and Kysela B. AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation. DNA Repair 3 (2004) 245-256
32. Wang Z., and Roeder R.G. Three human RNA polymerase III-specific subunits from a subcomplex with a selective function in specific transcription initiation. Genes Dev. 11 (1997) 1315-1326
33. Yunmei M.A., and Lieber M.R. In vitro nonhomologous DNA end joining system. Methods Enzymol. 408 (2006) 502-510