ATC0175: An orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety

CNS Drug Reviews

Volumn 11, Issue 4, 2005, Pages 341-352

  Chaki, Shigeyuki ^a   Yamaguchi, Jun Ichi ^a   Yamada, Hisaharu ^a   Thomsen, William ^b   Tran, Thuy Anh ^b   Semple, Graeme ^b   Sekiguchi, Yoshinori ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b ARENA PHARMACEUTICALS   (United States)

Author keywords

Anxiety; ATC0175; Depression; MCH; MCH1R; MCH2R; Melanin concentrating hormone

Indexed keywords

ATC 0175; CALCIUM ION; CORTICOTROPIN RELEASING FACTOR; HORMONE RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE 1 RECEPTOR; N [4 [[4 (DIMETHYLAMINO)QUINAZOLIN 2 YL]AMINO]CYCLOHEXYL] 3,4 DIFLUOROBENZAMIDE; SEROTONIN 1A RECEPTOR; SEROTONIN 2B RECEPTOR; UNCLASSIFIED DRUG; VASOPRESSIN V1 RECEPTOR; VASOPRESSIN V1B RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL MODEL; ANXIETY DISORDER; BINDING AFFINITY; BINDING ASSAY; CLIMBING; CONCENTRATION RESPONSE; DEPRESSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; EMOTION; FORCED SWIMMING TEST; GENOTOXICITY; HORMONE ACTION; HUMAN; HYPERTHERMIA; IC 50; LIVER MICROSOME; LOCOMOTION; MAZE TEST; MOTOR PERFORMANCE; MUTAGENICITY; NEUROTOXICITY; NONHUMAN; PSYCHOPHARMACOLOGY; REVIEW; ROTAROD TEST; SLEEP TIME; SOCIAL INTERACTION; STRESS; TOXICITY TESTING; TRANQUILIZING ACTIVITY;

EID: 33646538456     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.2005.tb00052.x     Document Type: Review

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