Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenous Schwann cells

Journal of Neuroscience

Volumn 16, Issue 10, 1996, Pages 3199-3208

  Honmou, Osamu ^b   Felts, Paul A ^b   Waxman, Stephen G ^b   Kocsis, Jeffery D ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

astrocytes; cell transplantation; demyelination; remyelination; restoration of conduction; Schwann cells

Indexed keywords

BETA GALACTOSIDASE; ETHIDIUM BROMIDE;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL TRANSPLANTATION; CONTROLLED STUDY; DEMYELINATION; GENETIC TRANSFECTION; GLIA; NERVE CONDUCTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REMYELINIZATION; REPORTER GENE; SCHWANN CELL; SPINAL CORD; X IRRADIATION;

EID: 0029881407     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-10-03199.1996     Document Type: Article

References (57)

1. Barrett EF, Barrett JN (1982) Intracellular recording from vertebrate myelinated axons: mechanism of the depolarizing afterpotential. J Physiol (Lond) 323:117-144.
2. Berthold C, Rydmark M (1995) Morphology of normal peripheral axons. In: The axon: structure, function and pathophysiology (Waxman SG, Kocsis JD, Stys PK, eds), pp 13-50. New York: Oxford UP.
3. Blakemore WF (1976) Invasion of Schwann cells into the spinal cord of the rat following local injections of lysolecithin. Neuropathol Appl Neurobiol 2:21-39.
4. Blakemore WF, Crang AJ (1985) The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system. J Neurol Sci 70:207-223.
5. Blakemore WF, Franklin RJ (1991) Transplantation of glial cells into the CNS. Trends Neurosci 14:323-327.
6. Blakemore WF, Patterson RC (1978) Suppression of remyelination in the CNS by x irradiation. Acta Neuropathol (Berl) 42:105-113.
7. Blakemore WF, Eames RA, Smith KJ, McDonald WI (1977) Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin. J Neurol Sci 33:31-43.
8. Blakemore WF, Crang AJ, Patterson RC (1987) Schwann cell remyelination of CNS axons following injection of cultures of CNS cells into areas of persistent demyelination. Neurosci Lett 77:20-24.
9. Blight AR (1983) Axonal physiology of chronic spinal cord injury in the cat: intracellular recording in vitro. Neuroscience 10:1471-1486.
10. Blight AR, Someya S (1985) Depolarizing afterpotentials in myelinated axons of mammalian spinal cord. Neuroscience 15:1-12.
11. Blight AR, Young W (1989) Central axons in injured cat spinal cord recover electro-physiological function following remyelination by Schwann cells. J Neurol Sci 91:15-34.
12. Brill MH, Waxman SG, Moore JW, Joyner RW (1977) Conduction velocity and spike configuration in myelinated fibres: computed dependence on internode distance. J Neurol Neurosurg Psychiatry 40:769-774.
13. Brockes JP, Fields KL, Raff MC (1979) Studies on cultured rat Schwann cells I. Establishment of purified populations from cultures of peripheral nerve. Brain Res 165:105-118.
14. Bunge RP, Puckett WR, Becerra JL, Marcillo A, Quencer RM (1993) Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination. In: Advances in neurology: neural injury and regeneration, Vol 59 (Seil FJ, ed), pp 75-89. New York: Raven.
15. Byrne TN, Waxman SG (1990) Spinal cord compression. Philadelphia: Davis.
16. Clifford-Jones RE, Landon DN, McDonald WI (1980) Remyelination during optic nerve compression. J Neurol Sci 46:239-243.
17. Duncan ID, Hammang JP, Jackson KF, Wood PM, Bunge RP, Langford I. (1988) Transplantation of oligodendrocytes and Schwann cells into the spinal cord of the myelin-deficient rat. J Neurocytol 17:351-360.
18. Felts PA, Smith KJ (1992) Conduction properties of central nerve fibers remyelinated by Schwann cells. Brain Res 574:178-192.
19. Franklin RJM, Crang AJ, Blakemore WF (1992) Type-1 astrocytes fail to inhibit Schwann cell remyelination of CNS axons in the absence of cells of the o-2a lineage. Dev Neurosci 14:85-92.
20. Ghatak NR, Hirano A, Doron Y, Zimmerman HM (1973) Remyelination in multiple sclerosis with peripheral type myelin. Arch Neurol 29:262-267.
21. Gledhill RF, McDonald WI (1977) Morphological characteristics of central demyelination and remyelination: a single-fiber study. Ann Neurol 522-560.
22. Gledhill RF, Harrison BM, McDonald WI (1973) Pattern of remyelination in the CNS. Nature 244:443-444.
23. Gout O, Dubois-Dalcq M (1993) Directed migration of transplanted glial cells toward a spinal cord demyelinating lesion. Int J Dev Neurosci 11:613-623.
24. Groves AK, Barnett SC, Franklin RJ, Crang AJ, Mayer M, Blakemore WF, Noble M (1993) Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells. Nature 362:453-455.
25. Harrison BM, McDonald WI (1977) Remyelination after transient experimental compression of the spinal cord. Ann Neurol 1:542-551.
26. Hines M, Shrager P (1991) A computational test of the requirements for conduction in demyelinated axons. Rest Neurol Neurosci 3:81-93.
27. Honmou O, Utzschneider DA, Rizzo MA, Bowe CM, Waxman SG, Kocsis JD (1994) Delayed depolarization and slow sodium currents in cutaneous afferents. J Neurophysiol 71:1627-1637.
28. Huxley AF, Stämpfli R (1949) Evidence for saltatory conduction in peripheral myelinated nerve fibres. J Physiol (Lond) 108:315-339.
29. Itoyama Y, Ohnishi A, Tateishi J, Kuroiwa Y, Webster HD (1985) Spinal cord multiple sclerosis lesions in Japanese patients: Schwann cell remyelination occurs in areas that lack glial flbriliary acidic protein (GFAP). Acta Neuropathol (Berl) 65:217-223.
30. Kapoor R, Smith KJ, Felts PA, Davies M (1993) Internodal potassium currents can generate ectopic impulses in mammalian myelinated axons. Brain Res 611:165-169.
31. Kocsis JD, Waxman SG (1980) Absence of potassium conductance in central myelinated axons. Nature 287:348-349.
32. Kocsis JD, Waxman SG (1982) Intra-axonal recordings in rat dorsal column axons: membrane hyperpolarization and decreased excitability precede the primary afferent depolarization. Brain Res 238:222-227.
33. Kocsis JD, Malenka RC, Waxman SG (1983) Effects of extracellular potassium concentration on the excitability of the parallel fibres of the rat cerebellum. J Physiol (Lond) 334:225-244.
34. Koles ZJ, Rasminsky M (1972) A computer simulation of conduction in demyelinated nerve fibres. J Physiol (Lond) 227:351-364.
35. Lachapelle F, Duhamel-Qerin E, Gansmuller A, Baron-Van Evercooren A, Villarroya H, Gumpel M (1994) Transplanted transgenically marked oligodendrocytes survive, migrate and myelinate in the normal mouse brain as they do in the shiverer mouse brain. Eur J Neurosci 6:814-824.
36. Levi AD, Bunge RP (1994) Studies of myelin formation after transplantation of human Schwann cells into the severe combined immunodeficient mouse. Exp Neurol 130:41-52.
37. Lindvall O, Sawle G, Widner H, Rothwell JC, Bjorklund A, Brooks D, Brundin P, Frackowiak R, Marsden CD, Odin P, Rehncrona S (1994) Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol 35:172-180.
38. Mann R, Mulligan RC, Baltimore D (1983) Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell 33:153-159.
39. McCarthy KD, de Vellis J (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85:890-902.
40. McDonald WI (1995) Overview of clinical aspects of multiple sclerosis, including cognitive deficit. In: The axon: structure, function and pathophysiology (Waxman SG, Kocsis JD, Stys PK, eds), pp 661-668. New York: Oxford UP.
41. Moore JW, Joyner RW, Brill MH, Waxman SG, Najar-Joa M (1978) Simulations of conduction in uniform myelinated fibres: relative sensitivity to changes in nodal and internodal parameters. Biophys J 21:147-161.
42. Peters A (1966) The node of Ranvier in the central nervous system. Q J Exp Physiol Cogn Med Sci 51:229-236.
43. Porter S, Blairclark M, Glaser L, Bunge RP (1986) Schwann cells stimulated to proliferate in the absence of neurons retain fuit functional capability. J Neurol Sci 6:3070-3078.
44. Price J, Turner D, Cepko C (1987) Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc Natl Acad Sci USA 84:156-160.
45. Prineas J, Connell F (1979) Remyelination in multiple sclerosis. Ann Neurol 5:22-31.
46. Ritchie JM, Rogart RB (1977) Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath. Proc Natl Acad Sci USA 74:211-215.
47. Rosenbluth J, Hasegawa M, Shirasaki N, Rosen CL, Liu Z (1990) Myelin formation following transplantation of normal fetal glia into myelin-deficient rat spinal cord. J Neurocytol 19:718-730.
48. Shrager P (1989) Sodium channels in single demyelinated mammalian axons. Brain Res 483:149-154.
49. Sims TJ, Gilmore SA, Waxman SG, Klinge E (1985) Dorsal-ventral differences in the glia limitans of the spinal cord: an ultrastructural study in developing normal and irradiated rats. J Neuropathol Exp Neurol 44:415-429.
50. Smith KJ, Blakemore WF, McDonald WI (1979) Central remyclination restores secure conduction. Nature 280:395-396.
51. Smith KJ, Blakemore WF, McDonald WI (1981) The restoration of conduction by central remyelination. Brain 104:383-404.
52. Utzschneider DA, Archer DR, Kocsis JD, Waxman SG, Duncan ID (1994) Transplantation of glial cells enhances action potential conduction of amyelinated spinal cord axons in the myelin-deficient rat. Proc Natl Acad Sci USA 91:53-57.
53. Vignais L, Nait Oumesmar B, Mellouk F, Gout O, Labourdette G, Baron-Van Evercooren A, Gumpel M (1993) Transplantation of oligodendrocyte precursors in the adult demyelinated spinal cord: migration and remyelination. Int J Dev Neurosci 11:603-612.
54. Waxman SG (1977) Conduction in myelinated, unmyelinated, and demyelmated fibers. Arch Neurol 34:585-589.
55. Waxman SG, Brill MH (1978) Conduction through demyelinated plaques in multiple sclerosis: computer simulations of facilitation by short internodes. J Neurol Neurosurg Psychiatry 41:408-417.
56. Waxman SG, Foster RE (1980) Development of the axon membrane during differentiation of myelinated fibres in spinal nerve roots. Proc R Soc Lond [Biol] 209:441-446.
57. Wiley-Livingston C, Ellisman MH (1980) Development of axonal membrane specializations defines nodes of Ranvier and precedes Schwann cell myelin elaboration. Dev Biol 79:334-355.