Lack of sensitivity of primary Fanconi's anemia fibroblasts to UV and ionizing radiation

Radiation Research

Volumn 161, Issue 3, 2004, Pages 318-325

  Kalb, Reinhard ^a   Duerr, Michael ^a   Wagner, Matthias ^a   Herterich, Sabine ^a   Gross, Michaela ^a   Digweed, Martin ^b   Joenje, Hans ^c   Hoehn, Holger ^a   Schindler, Detlev ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ANIMAL CELL; ARTICLE; ATAXIA TELANGIECTASIA; CELL CULTURE; CELL GROWTH; CELL HYPOXIA; COCKAYNE SYNDROME; COLONY FORMATION; CONTROLLED STUDY; FANCONI ANEMIA; GENOTYPE; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; SKIN FIBROBLAST; ULTRAVIOLET RADIATION; CELL DIVISION; CLONOGENIC ASSAY; COMPARATIVE STUDY; FIBROBLAST; GAMMA RADIATION; HUMAN; PATHOLOGY; PATHOPHYSIOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE;

CELL DIVISION; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; DOSE-RESPONSE RELATIONSHIP, RADIATION; FANCONI ANEMIA; FIBROBLASTS; GAMMA RAYS; HUMANS; RADIATION DOSAGE; RADIATION TOLERANCE; RADIATION, IONIZING; ULTRAVIOLET RAYS;

EID: 2442658200     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3138     Document Type: Article

References (41)

1. H. Joenje and K. J. Patel, The emerging genetic and molecular basis of Fanconi anaemia. Nat. Rev. Genet. 2, 446-457 (2001).
2. P. Guardiola, R. Pasquini, L. Dokal, J. J. Ortega, M. van Weel-Sipman, J. C. W. Marsh, S. E. Ball, F. Locatelli, C. Vermylen and E. Gluckman, Outcome of 69 allogeneic stem cell transplantations for Fanconi anemia using HLA-matched unrelated donors: A study on behalf of the European Group for Blood and Marrow Transplantation. Blood 95, 422-429 (2000).
3. C. S. Djuzenova, A. Rothfuss, U. Oppitz, G. Speit, D. Schindler, H. Hoehn and M. Flentje, Response to X-irradiation of Fanconi anemia homozygous and heterozygous cells assessed by the single-cell gel electrophoresis (comet) assay. Lab. Invest. 81, 185-192 (2001).
4. E. Gluckman, Radiosensitivity in Fanconi anemia: Application to the conditioning for bone marrow transplantation. Radiother. Oncol. 18 (Suppl. 1), 88-93 (1990).
5. M. L. MacMillan, A. D. Auerbach, S. M. Davies, T. E. DeFor, A. Gillio, R. Giller, R. Harris, M. Cairo, K. Dusenbery and J. E. Wagner, Haematopoietic cell transplantation in patients with Fanconi anaemia using alternate donors: Results of a total body irradiation dose escalation trial. Br. J. Haematol. 109, 121-129 (2000).
6. M. Carreau, N. Alon, L. Bosnoyan-Collins, H. Joenje and M. Buchwald, Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups. Mutat. Res. 435, 103-109 (1999).
7. H. Joenje, M. Levitus, Q. Waisfisz, A. D'Andrea, I. Garcia-Higuera, T. Pearson, C. G. van Berkel, M. A. Rooimans, N. Morgan and F. Arwert, Complementation analysis in Fanconi anemia: Assignment of the reference FA-H patient to group A. Am. J. Hum. Genet. 67, 759-762 (2000).
8. D. B. Busch, M. Z. Zdzienicka, A. T. Natarajan, N. J. Jones, W. J. Overkamp, A. Collins, D. L. Mitchell, M. Stefanini, E. Botta and L. H. Thompson, A CHO mutant, UV40, that is sensitive to diverse mutagens and represents a new complementation group of mitomycin C sensitivity. Mutat. Res. 363, 209-221 (1996).
9. J. B. Wilson, M. A. Johnson, A. P. Stuckert, K. L. Trueman, S. May, P. E. Bryant, R. E. Meyn, A. D. D'Andrea and N. J. Jones, The Chinese hamster FANCC/XRCC9 mutant NM3 fails to express the monoubiquinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange. Carcinogenesis 22, 1939-1946 (2001).
10. I. Garcia-Higuera, T. Taniguchi, S. Ganesan, M. S. Meyn, C. Timmers, J. Hejna, M. Grompe and A. D. D'Andrea, Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell. 7, 249-262 (2001).
11. H. Joenje, F. Arwert, A. W. Eriksson, H. de Koning and A. B. Oostra, Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia. Nature 290, 142-143 (1981).
12. D. Schindler and H. Hoehn, Fanconi anemia mutation causes cellular susceptibility to ambient oxygen. Am. J. Hum. Genet. 43, 429-435 (1988).
13. H. Joenje, A. B. Oostra, M. Wijker, F. M. di Summa, C. G. M. van Berkel, M. A. Rooimans, W. Ebell, L. van Weel, J. C. Pronk and F. Arwert, Evidence for at least eight Fanconi anemia genes. Am. J. Hum. Genet. 61, 940-924 (1997).
14. Fanconi Anemia Mutation Database, The Rockefeller University, http://rockefeller.edu/fanconi/mutate/default.html.
15. J. Pomp, J. L. Wike, I. J. M. Ouwerkerk, C. Hoogstraten, J. Davelaar, P. I. Schrier, J. W. H. Leer, H. D. Thames and W. A. Brock, Cell density dependent plating efficiency affects outcome and interpretation of colony forming assays. Radiother. Oncol. 40, 121-125 (1996).
16. J. B. Little, J. Nove, L. C. Strong and W. W. Nichols, Survival of human diploid skin fibroblasts from normal individuals after X-irradiation. Int. J. Radiat. Biol. 54, 899-910 (1988).
17. J. B. Little and J. Nove, Sensitivity of human diploid fibroblast cell strains from various genetic disorders to acute and protracted radiation exposure. Radiat. Res. 123, 87-92 (1990).
18. 2-phase chromosomal aberrations, and cell cycle delay. Cancer Res. 48, 4535-4538 (1988).
19. S. Ma, R-H. Fang and W. P. Chang, Heterogeneity in radiosensitivity of human diploid fibroblasts from keloids and normal skins. Cell Biol. Int. 20, 289-292 (1996).
20. J. N. DeSimone, H. Dolezalova, J. L. Redpath and E. J. Stanbridge, Prolonged cell cycle arrest in irradiated human diploid skin fibroblasts: The role of nutrient deprivation. Radiat. Res. 153, 131-143 (2000).
21. L. N. Su and J. B. Little, Transformation and radiosensitivity of human diploid skin fibroblasts transfected with activated ras oncogene and SV40 T-antigen. Int. J. Radiat. Biol. 62, 201-210 (1992).
22. L. N. Su and J. B. Little, Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and P53 binding domains. Int. J. Radiat. Biol. 62, 461-468 (1992).
23. N. M. Tsang, H. Nagasawa, C. Li and J. B. Little, Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. Oncogene 10, 2403-2408 (1995).
24. B. L. Kuehl, C. B. Brezden, R. D. Traver, D. Siegel, D. Ross, J. Renzing and A. M. Raum, Immortalisation of a human diploid fibroblast cell strain: A DT-diaphorase paradox. Br. J. Cancer 27 (Suppl.), S19-S22 (1996).
25. H. Saito, A. T. Hammond and R. E. Moses, Hypersensitivity to oxygen is a uniform and secondary defect in Fanconi anemia cells. Mutat. Res. 294, 255-262 (1993).
26. M. Futaki, T. Igarashi, S. Watanabe, S. Kajigaya, A. Tatsuguchi, J. Wang and J. M. Liu, The FANCG Fanconi anemia protein interacts with CYP2E1: Possible role in protection against oxidative DNA damage. Carcinogenesis 23, 67-72 (2002).
27. R. Iyer and B. E. Lehnert, Effects of ionizing radiation in targeted and nontargeted cells. Arch. Biochem. Biophys. 376, 14-25 (2000).
28. J. P. de Winter, Q. Waisfisz, M. A. Rooimans, C. G. M. van Berkel, L. Bosnoyan-Collins, N. Alon, M. Carreau, O. Bender, I. Demuth and H. Joenje, The Fanconi anaemia group G gene FANCG is identical with XRCC9. Nat. Genet. 20, 281-283 (1998).
29. J. Hansson, S. M. Keyse, T. Lindahl and R. D. Wood, DNA excision repair in cell extracts from human cell lines exhibiting hypersensitivity to DNA-damaging agents. Cancer Res. 51, 3384-3390 (1991).
30. T. Reuter, S. Herterich, O. Bernhard, H. Hoehn and H. J. Gross, Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system. Blood 95, 719-720 (2000).
31. J. F. Ward, The radiation-induced lesions which trigger the bystander effect. Mutat. Res. 499, 151-154 (2002).
32. G. Duckworth-Rysiecki and A. M. Taylor, Effects of ionizing radiation on cells from Fanconi's anemia patients. Cancer Res. 45, 416-420 (1985).
33. S. L. Donahue, R. Lundberg and C. Campbell, Deficient in vivo DNA end-joining in Fanconi anemia fibroblasts. Am. J. Hum. Genet. 69 (Suppl.), 216 (2001).
34. Y. M. N. Akkari, R. L. Bateman, C. A. Reifsteck, A. D. D'Andrea, S. B. Olsen and M. Grompe, The 4N cell cycle delay in Fanconi anemia reflects growth arrest in late S phase. Mol. Genet. Metabol. 74, 403-412 (2001).
35. R. A. Gatti, The inherited basis of human radiosensitivity. Acta Oncol. 40, 702-711 (2001).
36. M. Koomen, N. C. Cheng, H. J. van de Vrugt, B. C. Godthelp, M. A. van der Valk, A. B. Oostra, M. Z. Zdzienicka, H. Joenje and F. Arwert, Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice. Hum. Mol. Genet. 11, 273-281 (2002).
37. J. S. Loeffler, J. R. Harris, W. K. Dahlberg and J. B. Little, In vitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy for breast cancer. Radiat. Res. 121, 227-231 (1990).
38. B. P. Alter, Radiosensitivity in Fanconi's anemia patients. Radiother. Oncol. 62, 345-347 (2002).
39. Y. Marcoua, A. D'Andrea, P. A. Jeggo and P. N. Plowman, Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity. Radiother. Oncol. 60, 75-79 (2001).
40. N. G. Howlett, T. Taniguchi, S. Olsen, B. Cox, Q. Waisfisz, C. de Die-Smulders, N. Persky, M. Grompe, H. Joenje and A. D. D'Andrea, Biallelic inactivation of BRCA2 in Fanconi anemia. Science 297, 606-609 (2002).
41. S. L. Donahue, R. Lundberg, R. Saplis and C. Campell, Deficient regulation of DNA double-strand break repair in Fanconi anemia fibroblasts. J. Biol. Chem. 278, 29487-29495 (2003).