Unique pharmacology of KAR-2, a potential anti-cancer agent: Absorption modelling and selective mitotic spindle targeting

European Journal of Pharmaceutical Sciences

Volumn 36, Issue 1, 2009, Pages 11-19

  Gonzalez Alvarez, Isabel ^a   Gonzalez Alvarez, Marta ^b   Oltra Noguera, Davinia ^b   Merino, Virginia ^b   Tõkési, Natália ^c   Ovádi, Judit ^c   Bermejo, Marival ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

In situ in vitro correlation; KAR 2; Permeability; Vinblastine

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; GLYCOPROTEIN P; KAR 2; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DIFFUSION; DRUG PENETRATION; DRUG POTENCY; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; MATHEMATICAL MODEL; MICHAELIS CONSTANT; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; RAT; TURBIDIMETRY;

ALGORITHMS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INJECTIONS; INTESTINAL ABSORPTION; MALE; MITOTIC SPINDLE APPARATUS; MODELS, STATISTICAL; P-GLYCOPROTEIN; PERMEABILITY; RATS; RATS, WISTAR; SPECTROMETRY, FLUORESCENCE; VINBLASTINE;

EID: 58149129028     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.10.020     Document Type: Article

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