New anti-mitotic drugs with distinct anti-calmodulin activity

Mini-Reviews in Medicinal Chemistry

Volumn 6, Issue 10, 2006, Pages 1145-1157

  Orosz, F ^a   Horvath I ^a   Ovadi J ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Anticancer agent; Bisindoles; Calmodulin; Tubulin microtubule; Vinca alkaloid

Indexed keywords

3' ALLYL 2',4' DIOXO 3,5' SPIROOXAZOLIDINO 4 DEACETOXYVINBLASTINE; 3'(BETA CHLOROETHYL) 2',4 DIOXO 3,5' SPIROOXAZOLIDINO 4 DEACETOXYVINBLASTINE; 3'(BETA CHLOROETHYL) 2',4' DIOXO 3,5' SPIROOXAZOLIDINO 4 DEACETOXYVINCRISTINE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; ARALKYLAMINE; CALMIDAZOLIUM; CALMODULIN; CALMODULIN INHIBITOR; FELODIPINE; KAR 2; KAR 3; KAR 4; N (4 AMINOBUTYL) 5 CHLORO 2 NAPSYLAMIDE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; NAPHTHALENESULFONIC ACID DERIVATIVE; NAVELBINE; PHENOTHIAZINE DERIVATIVE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; VINBLASTINE; VINCA ALKALOID; VINCRISTINE; VINDESINE; VINDOLINE; VINFLUNINE;

ANTINEOPLASTIC ACTIVITY; CANCER; CANCER GRAFT; CYTOTOXICITY; DEPOLYMERIZATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; DRUG TOLERABILITY; HUMAN; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MITOSIS SPINDLE; NEUROTOXICITY; NONHUMAN; POLYMERIZATION; PROTEIN FUNCTION; REVIEW; STRUCTURE ACTIVITY RELATION; SYSTEMATIC REVIEW;

ANIMALS; ANTINEOPLASTIC AGENTS; CALMODULIN; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLE ALKALOIDS; MICROTUBULES; MITOSIS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 33749531924     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955706778560094     Document Type: Review

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