Restless-legs syndrome;Le syndrome des jambes sans repos

Revue Neurologique

Volumn 164, Issue 8-9, 2008, Pages 701-721

  Karroum, E ^a,b   Konofal, E ^a,b   Arnulf, I ^a,b  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

Akathisia; Pain; Parkinson's disease; Periodic limb movements; Restless legs syndrome

Indexed keywords

AMANTADINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BENSERAZIDE PLUS LEVODOPA; CLINDAMYCIN; CLOZAPINE; CODEINE; DOPAMINE RECEPTOR STIMULATING AGENT; DROPERIDOL; ESCITALOPRAM; FLUOXETINE; GABAPENTIN; HISTAMINE H2 RECEPTOR ANTAGONIST; IRON; LEVODOPA; NEUROLEPTIC AGENT; OLANZAPINE; OPIATE; PAROXETINE; PRAMIPEXOLE; PREGABALIN; QUETIAPINE; RISPERIDONE; ROPINIROLE; ROTIGOTINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRAMADOL; UNINDEXED DRUG;

AKATHISIA; ATTENTION DEFICIT DISORDER; AUTOSOMAL DOMINANT INHERITANCE; AUTOSOMAL RECESSIVE INHERITANCE; BRAIN METABOLISM; CHRONIC KIDNEY DISEASE; DIET SUPPLEMENTATION; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; DOPAMINERGIC SYSTEM; DOPPLER ECHOGRAPHY; DRUG EFFICACY; DRUG INDUCED DISEASE; FAMILY HISTORY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; HYPERACTIVITY; IDIOPATHIC DISEASE; INTERVIEW; IRON DEFICIENCY; IRON METABOLISM; LEG MOVEMENT; LEG PAIN; LOW DRUG DOSE; NEUROLOGIC DISEASE; ONSET AGE; PARKINSON DISEASE; PATHOPHYSIOLOGY; PERIPHERAL NEUROPATHY; PHENOTYPE; POLYSOMNOGRAPHY; PREGNANCY; QUALITY OF LIFE; QUESTIONNAIRE; RESTLESS LEGS SYNDROME; REVIEW; SLEEP DISORDER; HISTORY;

DOPAMINE AGENTS; HISTORY, 18TH CENTURY; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HUMANS; RESTLESS LEGS SYNDROME;

EID: 58149116654     PISSN: 00353787     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurol.2008.06.006     Document Type: Review

References (253)

1. AASM (2005). The international classification of sleep disorders: diagnostic and coding manual. 2nd ed. American Academy of Sleep Medicine (AASM). Westchester, Illinois. p. 297.
2. Abele M., Burk K., Laccone F., Dichgans J., and Klockgether T. Restless legs syndrome in spinocerebellar ataxia types 1, 2, and 3. J Neurol 248 (2001) 311-314
3. Abetz L., Arbuckle R., Allen R.P., Mavraki E., and Kirsch J. The reliability, validity and responsiveness of the restless legs syndrome quality of life questionnaire (RLSQoL) in a trial population. Health Qual Life Outcomes 3 (2005) 79
4. Abetz L., Vallow S.M., Kirsch J., Allen R.P., Washburn T., and Earley C.J. Validation of the restless legs syndrome quality of life questionnaire. Value Health 8 (2005) 157-167
5. Abril B., Carlander B., Touchon J., and Dauvilliers Y. Restless legs syndrome in narcolepsy: a side effect of sodium oxybate?. Sleep Med 8 (2007) 181-183
6. Adler C.H., Gwinn K.A., and Newman S. Olfactory function in restless legs syndrome. Mov Disord 13 (1998) 563-565
7. Agargun M.Y., Kara H., Ozbek H., Tombul T., and Ozer O.A. Restless legs syndrome induced by mirtazapine. J Clin Psychiatry 63 (2002) 1179
8. Akpinar S. Treatment of restless legs syndrome with levodopa plus benserazide. Arch Neurol 39 (1982) 739
9. Allen R.P., and Earley C.J. Augmentation of the restless legs syndrome with carbidopa/levodopa. Sleep 19 (1996) 205-213
10. Allen R.P., and Earley C.J. Defining the phenotype of the restless legs syndrome (RLS) using age-of-symptom-onset. Sleep Med 1 (2000) 11-19
11. Allen R.P., Barker P.B., Wehrl F., Song H.K., and Earley C.J. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 56 (2001) 263-265
12. Allen R.P., and Earley C.J. Validation of the Johns Hopkins restless legs severity scale. Sleep Med 2 (2001) 239-242
13. Allen R.P., La Buda M.C., Becker P., and Earley C.J. Family history study of the restless legs syndrome. Sleep Med Suppl. 3 (2002) S3-S7
14. Allen R.P., Kushida C.A., and Atkinson M.J. Factor analysis of the international restless legs syndrome study group's scale for restless legs severity. Sleep Med 4 (2003) 133-135
15. Allen R.P., Picchietti D., Hening W.A., Trenkwalder C., Walters A.S., and Montplaisir J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4 (2003) 101-119
16. Allen R.P., Walters A.S., Montplaisir J., et al. Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 165 (2005) 1286-1292
17. Allen R.P. Improving RLS diagnosis and severity assessment: polysomnography, actigraphy and RLS-sleep log. Sleep Med 8 Suppl. 2 (2007) S13-S18
18. Ancoli-Israel S., Kripke D.F., Klauber M.R., Mason W.J., Fell R., and Kaplan O. Periodic limb movements in sleep in community-dwelling elderly. Sleep 14 (1991) 496-500
19. Arnulf I., Bejjani B.P., Garma L., et al. Improvement of sleep architecture in PD with subthalamic nucleus stimulation. Neurology 55 (2000) 1732-1734
20. Arnulf I., Konofal E., Merino-Andreu M., et al. Parkinson's disease and sleepiness: an integral part of PD. Neurology 58 (2002) 1019-1024
21. Arnulf I., Merino-Andreu M., Bloch F., et al. REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy. Sleep 28 (2005) 349-354
22. Arnulf I., Nielsen J., Lohmann E., et al. Rapid eye movement sleep disturbances in huntington disease. Arch Neurol 65 (2008) 482-488
23. Atkinson M.J., Allen R.P., DuChane J., Murray C., Kushida C., and Roth T. Validation of the restless legs syndrome quality of life instrument (RLS-QLI): findings of a consortium of national experts and the RLS Foundation. Qual Life Res 13 (2004) 679-693
24. Azar S.A., Hatefi R., and Talebi M. Evaluation of effect of renal transplantation in treatment of restless legs syndrome. Transplant Proc 39 (2007) 1132-1133
25. Bahk W.M., Pae C.U., Chae J.H., Jun T.Y., and Kim K.S. Mirtazapine may have the propensity for developing a restless legs syndrome? A case report. Psychiatry Clin Neurosci 56 (2002) 209-210
26. Baker T.L., Guilleminault C., Nino-Murcia G., and Dement W.C. Comparative polysomnographic study of narcolepsy and idiopathic central nervous system hypersomnia. Sleep 9 (1986) 232-242
27. Bakshi R. Fluoxetine and restless legs syndrome. J Neurol Sci 142 (1996) 151-152
28. Balzac H.de. Béatrix (1839), Werdet, Paris
29. Bara-Jimenez W., Aksu M., Graham B., Sato S., and Hallett M. Periodic limb movements in sleep: state-dependent excitability of the spinal flexor reflex. Neurology 54 (2000) 1609-1616
30. Bassetti C.L., Mauerhofer D., Gugger M., Mathis J., and Hess C.W. Restless legs syndrome: a clinical study of 55 patients. Eur Neurol 45 (2001) 67-74
31. Baumann C.R., Marti I., and Bassetti C.L. Restless legs symptoms without periodic limb movements in sleep and without response to dopaminergic agents: a restless legs-like syndrome?. Eur J Neurol 14 (2007) 1369-1372
32. Benes H., Kaulfuss L., Muchalski T., and Kohnen R. Validation of an algorithm for the diagnoses of the restless legs syndrome: the restless legs syndrome-diagnostic index (RLS-DI). Sleep 28 (2005) A274
33. Benes H. Transdermal lisuride: short-term efficacy and tolerability study in patients with severe restless legs syndrome. Sleep Med 7 (2006) 31-35
34. Bentley A.J., Rosman K.D., and Mitchell D. Can the sensory symptoms of restless legs syndrome be assessed using a qualitative pain questionnaire?. Clin J Pain 23 (2007) 62-66
35. Berger K., von Eckardstein A., Trenkwalder C., Rothdach A., Junker R., and Weiland S.K. Iron metabolism and the risk of restless legs syndrome in an elderly general population - the MEMO-Study. J Neurol 249 (2002) 1195-1199
36. Berger K., Luedemann J., Trenkwalder C., John U., and Kessler C. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med 164 (2004) 196-202
37. Bhowmik D., Bhatia M., Gupta S., Agarwal S.K., Tiwari S.C., and Dash S.C. Restless legs syndrome in hemodialysis patients in India: a case controlled study. Sleep Med 4 (2003) 143-146
38. Boghen D., and Peyronnard J.M. Myoclonus in familial restless legs syndrome. Arch Neurol 33 (1976) 368-370
39. Boissier de Sauvages de la Croix F. Nosologie méthodique (1771), Hérissault, Paris
40. Bonati M.T., Ferini-Strambi L., Aridon P., Oldani A., Zucconi M., and Casari G. Autosomal dominant restless legs syndrome maps on chromosome 14q. Brain 126 (2003) 1485-1492
41. Bonin B., Vandel P., and Kantelip J.P. Mirtazapine and restless leg syndrome: a case report. Therapie 55 (2000) 655-656
42. Braga-Neto P., da Silva-Junior F.P., Sueli Monte F., de Bruin P.F., and de Bruin V.M. Snoring and excessive daytime sleepiness in Parkinson's disease. J Neurol Sci 217 (2004) 41-45
43. Castillo P.R., Kaplan J., Lin S.C., Fredrickson P.A., and Mahowald M.W. Prevalence of restless legs syndrome among native South Americans residing in coastal and mountainous areas. Mayo Clin Proc 81 (2006) 1345-1347
44. Cervenka S., Palhagen S.E., Comley R.A., et al. Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding. Brain 129 (2006) 2017-2028
45. Chen J.T., Garcia P.A., and Alldredge B.K. Zonisamide-induced restless legs syndrome. Neurology 60 (2003) 147
46. Chen S., Ondo W.G., Rao S., Li L., Chen Q., and Wang Q. Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p. Am J Hum Genet 74 (2004) 876-885
47. Clardy S.L., Earley C.J., Allen R.P., Beard J.L., and Connor J.R. Ferritin subunits in CSF are decreased in restless legs syndrome. J Lab Clin Med 147 (2006) 67-73
48. Coco DL,Cannizzaro E. Clindamycin-induced restless legs syndrome. Sleep Med 2008 (sous presse)
49. Connor J.R., Boyer P.J., Menzies S.L., et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 61 (2003) 304-309
50. Connor J.R., Wang X.S., Patton S.M., et al. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology 62 (2004) 1563-1567
51. Cortese S., Konofal E., Lecendreux M., et al. Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literature. Sleep 28 (2005) 1007-1013
52. Crochard A., El Hasnaoui A., Pouchain D., et al. Diagnostic indicators of restless legs syndrome in primary care consultations: the DESYR study. Mov Disord 22 (2007) 791-797 quiz 907
53. Dauvilliers Y., Pennestri M.H., Petit D., Dang-Vu T., Lavigne G., and Montplaisir J. Periodic leg movements during sleep and wakefulness in narcolepsy. J Sleep Res 16 (2007) 333-339
54. Desai A.V., Cherkas L.F., Spector T.D., and Williams A.J. Genetic influences in self-reported symptoms of obstructive sleep apnoea and restless legs: a twin study. Twin Res 7 (2004) 589-595
55. Desautels A., Turecki G., Montplaisir J., et al. Dopaminergic neurotransmission and restless legs syndrome: a genetic association analysis. Neurology 57 (2001) 1304-1306
56. Desautels A., Turecki G., Montplaisir J., Sequeira A., Verner A., and Rouleau G.A. Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q. Am J Hum Genet 69 (2001) 1266-1270
57. Desautels A., Turecki G., Montplaisir J., et al. Evidence for a genetic association between monoamine oxidase A and restless legs syndrome. Neurology 59 (2002) 215-219
58. Desautels A., Turecki G., Xiong L., Rochefort D., Montplaisir J., and Rouleau G.A. Mutational analysis of neurotensin in familial restless legs syndrome. Mov Disord 19 (2004) 90-94
59. Desautels A., Turecki G., Montplaisir J., et al. Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity. Arch Neurol 62 (2005) 591-596
60. Duggal H.S., and Mendhekar D.N. Clozapine-associated restless legs syndrome. J Clin Psychopharmacol 27 (2007) 89-90
61. Durif F., Vidailhet M., Bonnet A.M., Blin J., and Agid Y. Levodopa-induced dyskinesias are improved by fluoxetine. Neurology 45 (1995) 1855-1858
62. Earley C.J., Connor J.R., Beard J.L., Malecki E.A., Epstein D.K., and Allen R.P. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 54 (2000) 1698-1700
63. Earley C.J., Heckler D., and Allen R.P. The treatment of restless legs syndrome with intravenous iron dextran. Sleep Med 5 (2004) 231-235
64. Earley C.J., Heckler D., and Allen R.P. Repeated IV doses of iron provides effective supplemental treatment of restless legs syndrome. Sleep Med 6 (2005) 301-305
65. Earley CJ, P BB, Horska A, Allen RP, 2006. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep Med 7:458-61.
66. Eisensehr I., Wetter T.C., Linke R., et al. Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome. Neurology 57 (2001) 1307-1309
67. Eisensehr I., Ehrenberg B.L., Rogge Solti S., and Noachtar S. Treatment of idiopathic restless legs syndrome (RLS) with slow-release valproic acid compared with slow-release levodopa/benserazid. J Neurol 251 (2004) 579-583
68. Ekbom K.A. Restless legs: clinical study of hitherto overlooked disease in legs characterized by peculiar paresthesia ('Anxietas tibiarum'), pain and weakness and occurring in two main forms, asthenia crurum paraesthetica and asthenia crurum dolorosa. Acta Med Scand 158 Suppl. (1945) 1-123
69. Ekbom K.A. Restless legs syndrome. Neurology 10 (1960) 868-873
70. Ekbom K.A. Restless legs syndrome after partial gastrectomy. Acute Neurol Scand 42 (1966) 79-89
71. Evidente V.G., Adler C.H., Caviness J.N., Hentz J.G., and Gwinn-Hardy K. Amantadine is beneficial in restless legs syndrome. Mov Disord 15 (2000) 324-327
72. Evidente V.G. Piribedil for restless legs syndrome: a pilot study. Mov Disord 16 (2001) 579-581
73. Fantini M.L., Michaud M., Gosselin N., Lavigne G., and Montplaisir J. Periodic leg movements in REM sleep behavior disorder and related autonomic and EEG activation. Neurology 59 (2002) 1889-1894
74. Ferri R., Lanuzza B., Cosentino F.I., et al. A single question for the rapid screening of restless legs syndrome in the neurological clinical practice. Eur J Neurol 14 (2007) 1016-1021
75. Freye E., Levy J.V., and Partecke L. Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD) - correlation with neurophysiological parameters. Neurophysiol Clin 34 (2004) 81-89
76. Fulda S., and Wetter T.C. Is daytime sleepiness a neglected problem in patients with restless legs syndrome?. Mov Disord 22 (2007) S409-S413
77. Gamaldo C.E., Benbrook A.R., Allen R.P., Oguntimein O., and Earley C.J. A further evaluation of the cognitive deficits associated with restless legs syndrome (RLS). Sleep Med 9 (2008) 500-505
78. Garcia-Borreguero D., Larrosa O., de la Llave Y., Verger K., Masramon X., and Hernandez G. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Neurology 59 (2002) 1573-1579
79. Garcia-Borreguero D., Allen R.P., Kohnen R., et al. Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of sleep medicine-international restless legs syndrome study group consensus conference at the Max Planck Institute. Sleep Med 8 (2007) 520-530
80. Garcia-Borreguero D., Kohnen R., Hogl B., et al. Validation of the augmentation severity rating scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome. Sleep Med 8 (2007) 455-463
81. Garcia-Borreguero D., Winkelman J., Adams A., et al. Efficacy and tolerability of sumanirole in restless legs syndrome: a phase II, randomized, double-blind, placebo-controlled, dose-response study. Sleep Med 8 (2007) 119-127
82. Garvey M.J., and Tollefson G.D. Occurrence of myoclonus in patients treated with cyclic antidepressants. Arch Gen Psychiatry 44 (1987) 269-272
83. Gemignani F., Brindani F., Negrotti A., Vitetta F., Alfieri S., and Marbini A. Restless legs syndrome and polyneuropathy. Mov Disord 21 (2006) 1254-1257
84. Gemignani F., Brindani F., Vitetta F., Marbini A., and Calzetti S. Restless legs syndrome in diabetic neuropathy: a frequent manifestation of small fiber neuropathy. J Peripher Nerv Syst 12 (2007) 50-53
85. Ghorayeb I., et al. Perceived severity of restless legs syndrome across the female life cycle. Sleep Med 9 (2008) 799-802
86. Gilles de la Tourette G. Les états neurasthéniques (1898), Baillèrre JB et fils, Paris
87. Godau J., Schweitzer K.J., Liepelt I., Gerloff C., and Berg D. Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome. Mov Disord 22 (2007) 187-192
88. Godau J., et al. Sonographic abnormalities of brainstem structures in restless legs syndrome. Sleep Med 9 (2008) 782-789
89. Gomez-Esteban J.C., Zarranz J.J., Tijero B., et al. Restless legs syndrome in Parkinson's disease. Mov Disord 22 (2007) 1912-1916
90. Goodman J.D., Brodie C., and Ayida G.A. Restless leg syndrome in pregnancy. BMJ 297 (1988) 1101-1102
91. Grandjean P. Restless legs syndrome, report of experience. Schweiz Rundsch Med Prax 82 (1993) 1195-1197
92. Guilleminault C., Palombini L., Pelayo R., and Chervin R.D. Sleepwalking and sleep terrors in prepubertal children: what triggers them?. Pediatrics 111 (2003) e17-25
93. Haba-Rubio J., Staner L., Krieger J., and Macher J.P. Periodic limb movements and sleepiness in obstructive sleep apnea patients. Sleep Med 6 (2005) 225-229
94. Hadjigeorgiou G.M., Stefanidis I., Dardiotis E., et al. Low RLS prevalence and awareness in central Greece: an epidemiological survey. Eur J Neurol 14 (2007) 1275-1280
95. Happe S., and Zeitlhofer J. Abnormal cutaneous thermal thresholds in patients with restless legs syndrome. J Neurol 250 (2003) 362-365
96. Hargrave R., and Beckley D.J. Restless leg syndrome exacerbated by sertraline. Psychosomatics 39 (1998) 177-178
97. Heiman E.M., and Christie M. Lithium-aggravated nocturnal myoclonus and restless legs syndrome. Am J Psychiatry 143 (1986) 1191-1192
98. Hening W., Walters A.S., Allen R.P., Montplaisir J., Myers A., and Ferini-Strambi L. Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Med 5 (2004) 237-246
99. Hening W.A., Allen R.P., Thanner S., et al. The Johns Hopkins telephone diagnostic interview for the restless legs syndrome: preliminary investigation for validation in a multi-center patient and control population. Sleep Med 4 (2003) 137-141
100. Hening W.A., Allen R.P., Washburn M., Lesage S., and Earley C.J. Validation of the Hopkins telephone diagnostic interview for restless legs syndrome. Sleep Med 9 (2008) 283-289
101. Hicks A.A., Rye D.B., Kristjansson K., Sigmundssen T., Sigurdsson A.P., and Eiriksdottir I. Population-based confirmation of the 12q RLS locus in Iceland. Mov Disord 20 (2005) S34
102. Hogl B., Garcia-Borreguero D., Gschliesser V., Cabrero B., Kohnen R., and Allen R.P. On the development of the "structured interview for diagnosis of augmentation during rls treatment" (RLS-SIDA): first experiences. Sleep Med 6 (2005) S158 P092
103. Hogl B., Kiechl S., Willeit J., et al. Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology 64 (2005) 1920-1924
104. Holley J.L., Nespor S., and Rault R. Characterizing sleep disorders in chronic hemodialysis patients. ASAIO Trans 37 (1991) M456-457
105. Holmes R., Tluk S., Metta V., et al. Nature and variants of idiopathic restless legs syndrome: observations from 152 patients referred to secondary care in the UK. J Neural Transm 114 (2007) 929-934
106. Hornyak M., Voderholzer U., and Riemann D. Treatment of depression in patients with restless legs syndrome: what is evidence-based?. Sleep Med 7 (2006) 301-302 author reply 303-4
107. Hornyak M., Feige B., Voderholzer U., Philipsen A., and Riemann D. Polysomnography findings in patients with restless legs syndrome and in healthy controls: a comparative observational study. Sleep 30 (2007) 861-865
108. Iannaccone S., Zucconi M., Marchettini P., et al. Evidence of peripheral axonal neuropathy in primary restless legs syndrome. Mov Disord 10 (1995) 2-9
109. Iranzo A., Munoz E., Santamaria J., Vilaseca I., Mila M., and Tolosa E. REM sleep behavior disorder and vocal cord paralysis in Machado-Joseph disease. Mov Disord 18 (2003) 1179-1183
110. Iriarte J., Alegre M., Irimia P., Urriza J., and Artieda J. Clinical relevance of periodic limb movements during sleep in obstructive sleep apnea patients. Rev Neurol 30 (2000) 101-104
111. Kaplan P.W., Allen R.P., Buchholz D.W., and Walters J.K. A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene. Sleep 16 (1993) 717-723
112. Kedia S., Moro E., Tagliati M., Lang A.E., and Kumar R. Emergence of restless legs syndrome during subthalamic stimulation for Parkinson disease. Neurology 63 (2004) 2410-2412
113. Kemlink D., Polo O., Montagna P., et al. Family-based association study of the restless legs syndrome loci 2 and 3 in a European population. Mov Disord 22 (2007) 207-212
114. Kemlink D., Plazzi G., Vetrugno R., et al. Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13. Neurogenetics 9 (2008) 75-82
115. Kim S.W., Shin I.S., Kim J.M., Yang S.J., Shin H.Y., and Yoon J.S. Bupropion may improve restless legs syndrome: a report of three cases. Clin Neuropharmacol 28 (2005) 298-301
116. Kohnen R., Benes H., Heinrich C.R., and Kurella B. Development of the disease-specific restless legs syndrome quality of life (RLS-QoL) questionnaire. Mov Disord 17 (2002) S232 P743
117. Kohnen R., Stiasny-Kolster K., Oertel W., Benes H., and Trenkwalder C. Severity rating of restless legs syndrome: validation of the RLS-6 scales. Sleep 27 Abstract Suppl. (2004) A342
118. Konofal E., Arnulf I., Lecendreux M., and Mouren M.C. Ropinirole in a child with attention-deficit hyperactivity disorder and restless legs syndrome. Pediatr Neurol 32 (2005) 350-351
119. Konofal E., Lecendreux M., Deron J., et al. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol 38 (2008) 20-26
120. Kotagal S., and Silber M.H. Childhood-onset restless legs syndrome. Ann Neurol 56 (2004) 803-807
121. Kraus T., Schuld A., and Pollmacher T. Periodic leg movements in sleep and restless legs syndrome probably caused by olanzapine. J Clin Psychopharmacol 19 (1999) 478-479
122. Krishnan P.R., Bhatia M., and Behari M. Restless legs syndrome in Parkinson's disease: a case-controlled study. Mov Disord 18 (2003) 181-185
123. Kushida C., Martin M., Nikam P., et al. Burden of restless legs syndrome on health-related quality of life. Qual Life Res 16 (2007) 617-624
124. Lauerma H., and Markkula J. Treatment of restless legs syndrome with tramadol: an open study. J Clin Psychiatry 60 (1999) 241-244
125. Lazzarini A., Walters A.S., Hickey K., et al. Studies of penetrance and anticipation in five autosomal-dominant restless legs syndrome pedigrees. Mov Disord 14 (1999) 111-116
126. Lee K.A., Zaffke M.E., and Baratte-Beebe K. Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron. J Womens Health Gend Based Med 10 (2001) 335-341
127. Lesperance P., Djerroud N., Diaz Anzaldua A., Rouleau G.A., Chouinard S., and Richer F. Restless legs in Tourette syndrome. Mov Disord 19 (2004) 1084-1087
128. Leutgeb U., and Martus P. Regular intake of non-opioid analgesics is associated with an increased risk of restless legs syndrome in patients maintained on antidepressants. Eur J Med Res 7 (2002) 368-378
129. Levant B., and McCarson K.E. D(3) dopamine receptors in rat spinal cord: implications for sensory and motor function. Neurosci Lett 303 (2001) 9-12
130. Levchenko A., Montplaisir J.Y., Dube M.P., et al. The 14q restless legs syndrome locus in the French Canadian population. Ann Neurol 55 (2004) 887-891
131. Levchenko A., Provost S., Montplaisir J.Y., et al. A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13. Neurology 67 (2006) 900-901
132. Liebetanz K.M., Winkelmann J., Trenkwalder C., et al. RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity. Neurology 67 (2006) 320-321
133. Linke R., Eisensehr I., Wetter T.C., et al. Presynaptic dopaminergic function in patients with restless legs syndrome: are there common features with early Parkinson's disease?. Mov Disord 19 (2004) 1158-1162
134. Lohmann-Hedrich K., Neumann A., Kleensang A., et al. Evidence for linkage of restless legs syndrome to chromosome 9p: are there two distinct loci?. Neurology 70 (2008) 686-694
135. Loo H.V., and Tan E.K. Case-control study of restless legs syndrome and quality of sleep in Parkinson's disease. J Neurol Sci 266 (2008) 145-149
136. Lopes L.A., Lins Cde M., Adeodato V.G., et al. Restless legs syndrome and quality of sleep in type 2 diabetes. Diabetes Care 28 (2005) 2633-2636
137. Manconi M., Govoni V., De Vito A., et al. Restless legs syndrome and pregnancy. Neurology 63 (2004) 1065-1069
138. Manconi M., Govoni V., De Vito A., et al. Pregnancy as a risk factor for restless legs syndrome. Sleep Med 5 (2004) 305-308
139. Markkula J., and Lauerma H. Mianserin and restless legs. Int Clin Psychopharmacol 12 (1997) 53-58
140. Mathias R.A., Hening W., Washburn M., et al. Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnoses. Hum Hered 62 (2006) 157-164
141. Michaud M., Soucy J.P., Chabli A., Lavigne G., and Montplaisir J. SPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep. J Neurol 249 (2002) 164-170
142. Mizuno S., Mihara T., Miyaoka T., Inagaki T., and Horiguchi J. CSF iron, ferritin and transferrin levels in restless legs syndrome. J Sleep Res 14 (2005) 43-47
143. Montaigne M.de. Livre troisième. Essais. 1st ed. (1588), Langelier A, Paris
144. Montplaisir J., Godbout R., Boghen D., DeChamplain J., Young S.N., and Lapierre G. Familial restless legs with periodic movements in sleep: electrophysiologic, biochemical, and pharmacologic study. Neurology 35 (1985) 130-134
145. Montplaisir J., Godbout R., Poirier G., and Bedard M.A. Restless legs syndrome and periodic movements in sleep: physiopathology and treatment with l-dopa. Clin Neuropharmacol 9 (1986) 456-463
146. Montplaisir J., Boucher S., Poirier G., Lavigne G., Lapierre O., and Lesperance P. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord 12 (1997) 61-65
147. Montplaisir J., Boucher S., Nicolas A., et al. Immobilization tests and periodic leg movements in sleep for the diagnosis of restless leg syndrome. Mov Disord 13 (1998) 324-329
148. Mrowka M., Jobges M., Berding G., Schimke N., Shing M., and Odin P. Computerized movement analysis and beta-CIT-SPECT in patients with restless legs syndrome. J Neural Transm 112 (2005) 693-701
149. Nineb A., Rosso C., Dumurgier J., Nordine T., Lefaucheur J.P., and Creange A. Restless legs syndrome is frequently overlooked in patients being evaluated for polyneuropathies. Eur J Neurol 14 (2007) 788-792
150. Nomura T., Inoue Y., Miyake M., Yasui K., and Nakashima K. Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson's disease. Mov Disord 21 (2006) 380-384
151. Nordlander N.B. Therapy in restless legs. Acta Med Scand 145 (1953) 453-457
152. Nordlander N.B. Restless legs. Br J Phys Med 17 (1954) 160-162
153. O'Hare J.A., Abuaisha F., and Geoghegan M. Prevalence and forms of neuropathic morbidity in 800 diabetics. Ir J Med Sci 163 (1994) 132-135
154. O'Keeffe S.T., Noel J., and Lavan J.N. Restless legs syndrome in the elderly. Postgrad Med J 69 (1993) 701-703
155. O'Keeffe S.T., Gavin K., and Lavan J.N. Iron status and restless legs syndrome in the elderly. Age Ageing 23 (1994) 200-203
156. O'Sullivan R.L., and Greenberg D.B. H2 antagonists, restless leg syndrome, and movement disorders. Psychosomatics 34 (1993) 530-532
157. Oertel W.H., Benes H., Garcia-Borreguero D., et al. Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in Europe. Sleep Med 9 (2008) 228-239
158. Ondo W., and Jankovic J. Restless legs syndrome: clinicoetiologic correlates. Neurology 47 (1996) 1435-1441
159. Ondo W.G., Vuong K.D., and Wang Q. Restless legs syndrome in monozygotic twins: clinical correlates. Neurology 55 (2000) 1404-1406
160. Ondo W.G., Vuong K.D., and Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 59 (2002) 421-424
161. Ondo W.G. Methadone for refractory restless legs syndrome. Mov Disord 20 (2005) 345-348
162. Oppenheim H. Lehrbuch der nervenkrankheiten (1923), Karger, S. Berlin p. 1774
163. Page R.L., Ruscin J.M., Bainbridge J.L., and Brieke A.A. Restless legs syndrome induced by escitalopram: case report and review of the literature. Pharmacotherapy 28 (2008) 271-280
164. Paik I.H., Lee C., Choi B.M., Chae Y.L., and Kim C.E. Mianserin-induced restless legs syndrome. Br J Psychiatry 155 (1989) 415-417
165. Pearson V.E., Allen R.P., Dean T., Gamaldo C.E., Lesage S.R., and Earley C.J. Cognitive deficits associated with restless legs syndrome (RLS). Sleep Med 7 (2006) 25-30
166. Perroud N., Lazignac C., Baleydier B., Cicotti A., Maris S., and Damsa C. Restless legs syndrome induced by citalopram: a psychiatric emergency?. Gen Hosp Psychiatry 29 (2007) 72-74
167. Phillips B., Young T., Finn L., Asher K., Hening W.A., and Purvis C. Epidemiology of restless legs symptoms in adults. Arch Intern Med 160 (2000) 2137-2141
168. Picchietti D., Allen R.P., Walters A.S., Davidson J.E., Myers A., and Ferini-Strambi L. Restless legs syndrome: prevalence and impact in children and adolescents - the Peds REST study. Pediatrics 120 (2007) 253-266
169. Pichler I., Marroni F., Volpato C.B., et al. Linkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South Tyrolean population isolate. Am J Hum Genet 79 (2006) 716-723
170. Pinninti N.R., Mago R., Townsend J., and Doghramji K. Periodic restless legs syndrome associated with quetiapine use: a case report. J Clin Psychopharmacol 25 (2005) 617-618
171. Pittock S.J., Parrett T., Adler C.H., Parisi J.E., Dickson D.W., and Ahlskog J.E. Neuropathology of primary restless leg syndrome: absence of specific tau- and alpha-synuclein pathology. Mov Disord 19 (2004) 695-699
172. Polydefkis M., Allen R.P., Hauer P., Earley C.J., Griffin J.W., and McArthur J.C. Subclinical sensory neuropathy in late-onset restless legs syndrome. Neurology 55 (2000) 1115-1121
173. Quilici S., et al. Meta-analysis of the efficacy and tolerability of pramipexole versus ropinirole in the treatment of restless legs syndrome. Sleep Med 9 (2008) 715-726
174. Rangarajan S., and D'Souza G.A. Restless legs syndrome in Indian patients having iron deficiency anemia in a tertiary care hospital. Sleep Med 8 (2007) 247-251
175. Rangarajan S., Rangarajan S., and D'Souza G.A. Restless legs syndrome in an Indian urban population. Sleep Med 9 (2007) 88-93
176. Romigi A., Izzi F., Placidi F., Sperli F., Cervellino A., and Marciani M.G. Topiramate-induced restless legs syndrome: a report of two cases. J Neurol 254 (2007) 1120-1121
177. Rothdach A.J., Trenkwalder C., Haberstock J., Keil U., and Berger K. Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and morbidity in Augsburg elderly. Neurology 54 (2000) 1064-1068
178. Ruottinen H.M., Partinen M., Hublin C., et al. An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome. Neurology 54 (2000) 502-504
179. Rutkove S.B., Matheson J.K., and Logigian E.L. Restless legs syndrome in patients with polyneuropathy. Muscle Nerve 19 (1996) 670-672
180. Saletu M., Anderer P., Saletu-Zyhlarz G., et al. Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepam. Eur Neuropsychopharmacol 11 (2001) 153-161
181. Salin-Pascual R.J., Galicia-Polo L., and Drucker-Colin R. Sleep changes after 4 consecutive days of venlafaxine administration in normal volunteers. J Clin Psychiatry 58 (1997) 348-350
182. San Pedro E.C., Mountz J.M., Mountz J.D., Liu H.G., Katholi C.R., and Deutsch G. Familial painful restless legs syndrome correlates with pain dependent variation of blood flow to the caudate, thalamus, and anterior cingulate gyrus. J Rheumatol 25 (1998) 2270-2275
183. Sanz-Fuentenebro F.J., Huidobro A., and Tejadas-Rivas A. Restless legs syndrome and paroxetine. Acta Psychiatr Scand 94 (1996) 482-484
184. Scherbaum N., Stuper B., Bonnet U., and Gastpar M. Transient restless legs-like syndrome as a complication of opiate withrawal. Pharmacopsychiatry 36 (2003) 70-72
185. Schmidauer C., Sojer M., Seppi K., et al. Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome. Ann Neurol 58 (2005) 630-634
186. Schols L., Haan J., Riess O., Amoiridis G., and Przuntek H. Sleep disturbance in spinocerebellar ataxias: is the SCA3 mutation a cause of restless legs syndrome?. Neurology 51 (1998) 1603-1607
187. Sevim S., Dogu O., Camdeviren H., et al. Unexpectedly low prevalence and unusual characteristics of RLS in Mersin, Turkey. Neurology 61 (2003) 1562-1569
188. Sevim S., Dogu O., Kaleagasi H., Aral M., Metin O., and Camdeviren H. Correlation of anxiety and depression symptoms in patients with restless legs syndrome: a population based survey. J Neurol Neurosurg Psychiatry 75 (2004) 226-230
189. Sforza E., Johannes M., and Claudio B. The PAM-RL ambulatory device for detection of periodic leg movements: a validation study. Sleep Med 6 (2005) 407-413
190. Silber M.H., and Richardson J.W. Multiple blood donations associated with iron deficiency in patients with restless legs syndrome. Mayo Clin Proc 78 (2003) 52-54
191. Skomro R.P., Ludwig S., Salamon E., and Kryger M.H. Sleep complaints and restless legs syndrome in adult type 2 diabetics. Sleep Med 2 (2001) 417-422
192. Sloand J.A., Shelly M.A., Feigin A., Bernstein P., and Monk R.D. A double-blind, placebo-controlled trial of intravenous iron dextran therapy in patients with ESRD and restless legs syndrome. Am J Kidney Dis 43 (2004) 663-670
193. Smith R.C. Relationship of periodic movements in sleep (nocturnal myoclonus) and the Babinski sign. Sleep 8 (1985) 239-243
194. Sommer M., Bachmann C.G., Liebetanz K.M., Schindehutte J., Tings T., and Paulus W. Pregabalin in restless legs syndrome with and without neuropathic pain. Acta Neurol Scand 115 (2007) 347-350
195. Stefansson H., Rye D.B., Hicks A., et al. A genetic risk factor for periodic limb movements in sleep. N Engl J Med 357 (2007) 639-647
196. Stiasny-Kolster K., Magerl W., Oertel W.H., Moller J.C., and Treede R.D. Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome. Brain 127 (2004) 773-782
197. Stiasny-Kolster K., Kohnen R., Moller J.C., Trenkwalder C., and Oertel W.H. Validation of the "l-DOPA test" for diagnosis of restless legs syndrome. Mov Disord 21 (2006) 1333-1339
198. Sun E.R., Chen C.A., Ho G., Earley C.J., and Allen R.P. Iron and the restless legs syndrome. Sleep 21 (1998) 371-377
199. Suzuki K., Ohida T., Sone T., et al. The prevalence of restless legs syndrome among pregnant women in Japan and the relationship between restless legs syndrome and sleep problems. Sleep 26 (2003) 673-677
200. Tan E.K., Seah A., See S.J., Lim E., Wong M.C., and Koh K.K. Restless legs syndrome in an Asian population: a study in Singapore. Mov Disord 16 (2001) 577-579
201. Tan E.K., Lum S.Y., and Wong M.C. Restless legs syndrome in Parkinson's disease. J Neurol Sci 196 (2002) 33-36
202. Teive H.A., de Quadros A., Barros F.C., and Werneck L.C. Worsening of autosomal dominant restless legs syndrome after use of mirtazapine: case report. Arq Neuropsiquiatr 60 (2002) 1025-1029
203. Telarovic S., Relja M., and Trkulja V. Restless legs syndrome in hemodialysis patients: association with calcium antagonists. A preliminary report. Eur Neurol 58 (2007) 166-169
204. Telstad W., Sorensen O., Larsen S., Lillevold P.E., Stensrud P., and Nyberg-Hansen R. Treatment of the restless legs syndrome with carbamazepine: a double blind study. Br Med J (Clin Res Ed) 288 (1984) 444-446
205. Terao T., Terao M., Yoshimura R., and Abe K. Restless legs syndrome induced by lithium. Biol Psychiatry 30 (1991) 1167-1170
206. Tergau F., Wischer S., Wolf C., and Paulus W. Treatment of restless legs syndrome with the dopamine agonist alpha-dihydroergocryptine. Mov Disord 16 (2001) 731-735
207. Tison F., Crochard A., Leger D., Bouee S., Lainey E., and El Hasnaoui A. Epidemiology of restless legs syndrome in French adults: a nationwide survey: the INSTANT study. Neurology 65 (2005) 239-246
208. Trenkwalder C., Seidel V.C., Gasser T., and Oertel W.H. Clinical symptoms and possible anticipation in a large kindred of familial restless legs syndrome. Mov Disord 11 (1996) 389-394
209. Trenkwalder C., Walters A.S., Hening W.A., et al. Positron emission tomographic studies in restless legs syndrome. Mov Disord 14 (1999) 141-145
210. Trenkwalder C., Garcia-Borreguero D., Montagna P., et al. Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries. J Neurol Neurosurg Psychiatry 75 (2004) 92-97
211. Trenkwalder C., Hundemer H.P., Lledo A., et al. Efficacy of pergolide in treatment of restless legs syndrome: the PEARLS study. Neurology 62 (2004) 1391-1397
212. Trenkwalder C., Paulus W., and Walters A.S. The restless legs syndrome. Lancet Neurol 4 (2005) 465-475
213. Trenkwalder C., Benes H., Grote L., et al. Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: results from a multi-center, randomized, active controlled trial. Mov Disord 22 (2007) 696-703
214. Trenkwalder C., Hogl B., Benes H., and Kohnen R. Augmentation in restless legs syndrome is associated with low ferritin. Sleep Med 9 (2008) 572-574
215. Tribl G.G., Asenbaum S., Happe S., Bonelli R.M., Zeitlhofer J., and Auff E. Normal striatal D2 receptor binding in idiopathic restless legs syndrome with periodic leg movements in sleep. Nucl Med Commun 25 (2004) 55-60
216. Tunc T., Karadag Y.S., Dogulu F., and Inan L.E. Predisposing factors of restless legs syndrome in pregnancy. Mov Disord 22 (2007) 627-631
217. Turjanski N., Lees A.J., and Brooks D.J. Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology 52 (1999) 932-937
218. Ulfberg J., Nystrom B., Carter N., and Edling C. Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms. Mov Disord 16 (2001) 1159-1163
219. Ulfberg J., and Nystrom B. Restless legs syndrome in blood donors. Sleep Med 5 (2004) 115-118
220. Ulfberg J., Bjorvatn B., Leissner L., et al. Comorbidity in restless legs syndrome among a sample of Swedish adults. Sleep Med 8 (2007) 768-772
221. Velasco P.E., Goiburu J.A., and Pinel R.S. Restless legs syndrome induced by zonisamide. Mov Disord 22 (2007) 1517-1518
222. Vetrugno R., La Morgia C., D'Angelo R., et al. Augmentation of restless legs syndrome with long-term tramadol treatment. Mov Disord 22 (2007) 424-427
223. Voderholzer U., Muller N., Haag C., Riemann D., and Straube A. Periodic limb movements during sleep are a frequent finding in patients with Gilles de la Tourette's syndrome. J Neurol 244 (1997) 521-526
224. von Spiczak S., Whone A.L., Hammers A., et al. The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study. Brain 128 (2005) 906-917
225. Wagner M.L., Walters A.S., Coleman R.G., Hening W.A., Grasing K., and Chokroverty S. Randomized, double-blind, placebo-controlled study of clonidine in restless legs syndrome. Sleep 19 (1996) 52-58
226. Walters A.S., Hening W.A., Kavey N., Chokroverty S., and Gidro-Frank S. A double-blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome. Ann Neurol 24 (1988) 455-458
227. Walters A.S., Picchietti D., Hening W., and Lazzarini A. Variable expressivity in familial restless legs syndrome. Arch Neurol 47 (1990) 1219-1220
228. Walters A.S., Wagner M.L., Hening W.A., et al. Successful treatment of the idiopathic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo. Sleep 16 (1993) 327-332
229. Walters A.S., and The International Restless Legs Syndrome Study Group. Toward a better definition of the restless legs syndrome. Mov Disord 10 (1995) 634-642
230. Walters A.S., Mandelbaum D.E., Lewin D.S., Kugler S., England S.J., Miller M., and Dopaminergic Therapy Study Group. Dopaminergic therapy in children with restless legs/periodic limb movements in sleep and ADHD. Pediatr Neurol 22 (2000) 182-186
231. Walters A.S., LeBrocq C., Dhar A., et al. Validation of the international restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med 4 (2003) 121-132
232. Ward N.G. Akathisia associated with droperidol during epidural anesthesia. Anesthesiology 71 (1989) 786-787
233. Wetter T.C., Collado-Seidel V., Pollmacher T., Yassouridis A., and Trenkwalder C. Sleep and periodic leg movement patterns in drug-free patients with Parkinson's disease and multiple system atrophy. Sleep 23 (2000) 361-367
234. Wetter T.C., Brunner J., and Bronisch T. Restless legs syndrome probably induced by risperidone treatment. Pharmacopsychiatry 35 (2002) 109-111
235. Willis T. The London practice of physic (1685), Bassett and Crooke, London p. 404
236. Winkelman J.W., Chertow G.M., and Lazarus J.M. Restless legs syndrome in end-stage renal disease. Am J Kidney Dis 28 (1996) 372-378
237. Winkelman J.W., Finn L., and Young T. Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort. Sleep Med 7 (2006) 545-552
238. Winkelman J.W., Sethi K.D., Kushida C.A., et al. Efficacy and safety of pramipexole in restless legs syndrome. Neurology 67 (2006) 1034-1039
239. Winkelman J.W., Shahar E., Sharief I., and Gottlieb D.J. Association of restless legs syndrome and cardiovascular disease in the sleep heart health study. Neurology 70 (2008) 35-42
240. Winkelmann J., Wetter T.C., Collado-Seidel V., et al. Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients. Sleep 23 (2000) 597-602
241. Winkelmann J., Muller-Myhsok B., Wittchen H.U., et al. Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families. Ann Neurol 52 (2002) 297-302
242. Winkelmann J., Stautner A., Samtleben W., and Trenkwalder C. Long-term course of restless legs syndrome in dialysis patients after kidney transplantation. Mov Disord 17 (2002) 1072-1076
243. Winkelmann J., Prager M., Lieb R., et al. "Anxietas tibiarum". Depression and anxiety disorders in patients with restless legs syndrome. J Neurol 252 (2005) 67-71
244. Winkelmann J., Lichtner P., Kemlink D., et al. New loci for restless legs syndrome map to chromosome 4q and 17p. Mov Disord 21 (2006) S412
245. Winkelmann J., Lichtner P., Putz B., et al. Evidence for further genetic locus heterogeneity and confirmation of RLS-1 in restless legs syndrome. Mov Disord 21 (2006) 28-33
246. Winkelmann J., Schormair B., Lichtner P., et al. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet 39 (2007) 1000-1006
247. Winkelmann J., Lichtner P., Schormair B., et al. Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome. Mov Disord 23 (2008) 350-358
248. Wittmaack T. Pathologie und therapie der sensibilitatneurosen (1861), Schafer E, Leipzig p. 459
249. Woloshin S., and Schwartz L.M. Giving legs to restless legs: a case study of how the media helps make people sick. PLoS Med 3 (2006) e170
250. Xiong L., Dion P., Montplaisir J., et al. Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families. Am J Med Genet B Neuropsychiatr Genet 144 (2007) 911-917
251. Xiong L., Jang K., Montplaisir J., et al. Canadian restless legs syndrome twin study. Neurology 68 (2007) 1631-1633
252. Xiong L., Levchenko A., Montplaisir J., et al. Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians. Sleep Med 9 (2008) 273-282
253. Yang C., White D.P., and Winkelman J.W. Antidepressants and periodic leg movements of sleep. Biol Psychiatry 58 (2005) 510-514