Sonographic abnormalities of brainstem structures in restless legs syndrome

Sleep Medicine

Volumn 9, Issue 7, 2008, Pages 782-789

  Godau, Jana ^a   Wevers, Anne Kathrin ^a   Gaenslen, Alexandra ^a   Di Santo, Adriana ^a   Liepelt, Inga ^a   Gasser, Thomas ^a   Berg, Daniela ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Brainstem; Iron; Raphe; Red nucleus; RLS; Substantia nigra; Transcranial sonography

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; B SCAN; BASAL GANGLION; BRAIN STEM; BRAIN VENTRICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE MARKER; FAMILY HISTORY; FEMALE; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; RED NUCLEUS; RESTLESS LEGS SYNDROME; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; VALIDATION PROCESS;

ADULT; AGED; AGED, 80 AND OVER; BRAIN STEM; DOMINANCE, CEREBRAL; ECHOENCEPHALOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYSOMNOGRAPHY; RAPHE NUCLEI; RED NUCLEUS; RESTLESS LEGS SYNDROME; SUBSTANTIA NIGRA; YOUNG ADULT;

EID: 51649126777     PISSN: 13899457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sleep.2007.09.001     Document Type: Article

References (35)

1. Walters A.S. Toward a better definition of the restless legs syndrome. The international restless legs syndrome study group. Mov Disord 10 (1995) 634-642
2. Allen R.P., Picchietti D., Hening W.A., Trenkwalder C., Walters A.S., and Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4 (2003) 101-119
3. Allen R.P., Walters A.S., Montplaisir J., et al. Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 165 (2005) 1286-1292
4. Tison F., Crochard A., Leger D., Bouee S., Lainey E., and El Hasnaoui A. Epidemiology of restless legs syndrome in French adults: a nationwide survey: the INSTANT study. Neurology 65 (2005) 239-246
5. McCrink L., Allen R.P., Wolowacz S., Sherrill B., Connolly M., and Kirsch J. Predictors of health-related quality of life in sufferers with restless legs syndrome: a multi-national study. Sleep Med 8 (2007) 73-83
6. Banno K., Delaive K., Walld R., and Kryger M.H. Restless legs syndrome in 218 patients: associated disorders. Sleep Med 1 (2000) 221-229
7. Earley C.J., Connor J.R., Beard J.L., Malecki E.A., Epstein D.K., and Allen R.P. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 54 (2000) 1698-1700
8. Garcia-Borreguero D., Larrosa O., de la Llave Y., Granizo J.J., and Allen R. Correlation between rating scales and sleep laboratory measurements in restless legs syndrome. Sleep Med 5 (2004) 561-565
9. Montplaisir J., Boucher S., Nicolas A., et al. Immobilization tests and periodic leg movements in sleep for the diagnosis of restless leg syndrome. Mov Disord 13 (1998) 324-329
10. Bucher S.F., Trenkwalder C., and Oertel W.H. Reflex studies and MRI in the restless legs syndrome. Acta Neurol Scand 94 (1996) 145-150
11. Turjanski N., Lees A.J., and Brooks D.J. Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology 52 (1999) 932-937
12. Michaud M., Soucy J.P., Chabli A., Lavigne G., and Montplaisir J. SPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep. J Neurol 249 (2002) 164-170
13. Etgen T., Draganski B., Ilg C., et al. Bilateral thalamic gray matter changes in patients with restless legs syndrome. Neuroimage 24 (2005) 1242-1247
14. Earley C.J., P B.B., Horska A., and Allen R.P. MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome. Sleep Med 7 (2006) 458-461
15. Schmidauer C., Sojer M., Seppi K., et al. Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome. Ann Neurol 58 (2005) 630-634
16. Godau J., Schweitzer K.J., Liepelt I., Gerloff C., and Berg D. Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome. Mov Disord 22 (2007) 187-192
17. Berg D. Transcranial sonography in the early and differential diagnosis of Parkinson's disease. J Neural Transm Suppl (2006) 249-254
18. APA - American psychiatric association: diagnostic and statistical manual of mental disorders. DSM-IV-TR. 4th ed; American Psychiatric Association; Washington, DC; 2000 [Text Revision].
19. Becker G., Becker T., Struck M., et al. Reduced echogenicity of brainstem raphe specific to unipolar depression: a transcranial color-coded real-time sonography study. Biol Psychiatry 38 (1995) 180-184
20. Becker G., Berg D., Lesch K.P., and Becker T. Basal limbic system alteration in major depression: a hypothesis supported by transcranial sonography and MRI findings. Int J Neuropsychopharmacol 4 (2001) 21-31
21. Berg D., Supprian T., Hofmann E., et al. Depression in Parkinson's disease: brainstem midline alteration on transcranial sonography and magnetic resonance imaging. J Neurol 246 (1999) 1186-1193
22. Walters A.S., LeBrocq C., Dhar A., et al. Validation of the International restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med 4 (2003) 121-132
23. Beck A.T., and Beamesderfer A. Assessment of depression: the depression inventory. Mod Probl Pharmacopsychiatry 7 (1974) 151-169
24. Beck A.T., and Steer R.A. Internal consistencies of the original and revised Beck depression inventory. J Clin Psychol 40 (1984) 1365-1367
25. Becker G., and Berg D. Neuroimaging in basal ganglia disorders: perspectives for transcranial ultrasound. Mov Disord 16 (2001) 23-32
26. Berg D., and Becker G. Perspectives of B-mode transcranial ultrasound. Neuroimage 15 (2002) 463-473
27. Bucher S.F., Seelos K.C., Oertel W.H., Reiser M., and Trenkwalder C. Cerebral generators involved in the pathogenesis of the restless legs syndrome. Ann Neurol 41 (1997) 639-645
28. Allen R.P., Barker P.B., Wehrl F., Song H.K., and Earley C.J. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 56 (2001) 263-265
29. Connor J.R., Boyer P.J., Menzies S.L., et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 61 (2003) 304-309
30. Berg D. In vivo detection of iron and neuromelanin by transcranial sonography - a new approach for early detection of substantia nigra damage. J Neural Transm 113 (2006) 775-780
31. Berg D., Grote C., Rausch W.D., et al. Iron accumulation in the substantia nigra in rats visualized by ultrasound. Ultrasound Med Biol 25 (1999) 901-904
32. Berg D., Roggendorf W., Schroder U., et al. Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury. Arch Neurol 59 (2002) 999-1005
33. Rothdach A.J., Trenkwalder C., Haberstock J., Keil U., and Berger K. Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and morbidity in Augsburg Elderly. Neurology 54 (2000) 1064-1068
34. Berg D., Merz B., Reiners K., Naumann M., and Becker G. Five-year follow-up study of hyperechogenicity of the substantia nigra in Parkinson's disease. Mov Disord 20 (2005) 383-385
35. Iova A., Garmashov A., Androuchtchenko N., et al. Postnatal decrease in substantia nigra echogenicity. Implications for the pathogenesis of Parkinson's disease. J Neurol 251 (2004) 1451-1454