4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats

Toxicological Sciences

Volumn 107, Issue 1, 2009, Pages 293-297

  Jefferson, Felicia A ^a   Xiao, Gong H ^a,c   Hein, David W ^b  

^a University of Louisville School of Medicine   (United States)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

^c HEALTH CANADA   (Canada)

Author keywords

4 aminobiphenyl; Downregulation; Heterocyclic amines; Mammary epithelial cells; N acetyltransferase 1; N acetyltransferase 2

Indexed keywords

2 FLUORENYLAMINE; 4 AMINOBIPHENYL N ACYLTRANSFERASE; 4 BIPHENYLAMINE; ACYLTRANSFERASE; ARYLAMINE ACETYLTRANSFERASE; CARCINOGEN; N ACETYLTRANSFERASE 1; N HYDROXY 2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; N HYDROXY 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE O ACYLTRANSFERASE; PYRIDINE DERIVATIVE; SULFADIMIDINE; TRANSFERASE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CATALYSIS; CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENOTYPE; NONHUMAN; RAT;

4-AMINOBENZOIC ACID; ACETYLATION; AMINOBIPHENYL COMPOUNDS; ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; CARCINOGENS; CELLS, CULTURED; DOWN-REGULATION; FLUORENES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MAMMARY GLANDS, ANIMAL; POLYMORPHISM, GENETIC; RATS; SULFAMETHAZINE;

RATTUS;

EID: 58049221167     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn216     Document Type: Article

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