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Volumn 279, Issue 21, 2004, Pages 22131-22137
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Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: A mechanism for the slow acetylator phenotype and substrate-dependent down-regulation
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Author keywords
[No Author keywords available]
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Indexed keywords
PROTEASOMAL DEGRADATION;
PROTEIN ACETYLATION;
DEGRADATION;
GENES;
ORGANIC ACIDS;
OXIDATION;
TOXICITY;
TUMORS;
BIOCHEMISTRY;
4 AMINOBENZOIC ACID;
ACYLTRANSFERASE;
ALLOENZYME;
CYSTEINE;
N ACETYLTRANSFERASE 1;
PROTEASOME;
UNCLASSIFIED DRUG;
ACETYLATION;
ACETYLATOR PHENOTYPE;
ALLELE;
ARTICLE;
CANCER;
CONTROLLED STUDY;
DETOXIFICATION;
ENVIRONMENTAL FACTOR;
ENZYME ACTIVE SITE;
ENZYME ACTIVITY;
ENZYME DEGRADATION;
ENZYME REGULATION;
ENZYME SUBSTRATE COMPLEX;
GENE MUTATION;
HALF LIFE TIME;
HUMAN;
HUMAN CELL;
OXIDATIVE STRESS;
PRIORITY JOURNAL;
PROTEIN EXPRESSION;
SITE DIRECTED MUTAGENESIS;
UBIQUITINATION;
4-AMINOBENZOIC ACID;
ALLELES;
ARYLAMINE N-ACETYLTRANSFERASE;
BINDING SITES;
BLOTTING, WESTERN;
CELL LINE, TUMOR;
CLONING, MOLECULAR;
CYCLOHEXIMIDE;
CYSTEINE;
CYSTEINE ENDOPEPTIDASES;
CYSTEINE PROTEINASE INHIBITORS;
DNA, COMPLEMENTARY;
DOWN-REGULATION;
ESCHERICHIA COLI;
GENOTYPE;
GLUTATHIONE TRANSFERASE;
HUMANS;
ISOENZYMES;
LEUKOCYTES, MONONUCLEAR;
LEUPEPTINS;
MODELS, BIOLOGICAL;
MULTIENZYME COMPLEXES;
MUTAGENESIS, SITE-DIRECTED;
MUTATION;
OXIDATIVE STRESS;
PEPTIDE HYDROLASES;
PHENOTYPE;
PRECIPITIN TESTS;
PROTEASOME ENDOPEPTIDASE COMPLEX;
PROTEIN BINDING;
PROTEIN SYNTHESIS INHIBITORS;
RECOMBINANT PROTEINS;
TIME FACTORS;
UBIQUITIN;
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EID: 2542462930
PISSN: 00219258
EISSN: None
Source Type: Journal
DOI: 10.1074/jbc.M312858200 Document Type: Article |
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Times cited : (78)
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References (25)
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