Genetic screen for genes involved in Chk2 signaling in Drosophila

Molecules and Cells

Volumn 26, Issue 4, 2008, Pages 350-355

  Park, Suk Young ^a   Song, Young Han ^a  

^a Hallym University   (South Korea)

Author keywords

Apoptosis; Cell cycle; Chk2; DNA damage response; Drosophila; Genetic screen

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 2; DROSOPHILA PROTEIN; PROTEIN EP(2)1027; PROTEIN EP(2)2056; PROTEIN EP(2)2081; PROTEIN EP(2)2124; PROTEIN EP(2)2161; PROTEIN EP(2)2522; PROTEIN EP(2)2576; PROTEIN EP(3)0417; PROTEIN EP(3)0703; PROTEIN EP(3)0772; PROTEIN EP(3)0863; PROTEIN EP(3)0902; PROTEIN EP(3)1105; PROTEIN EP(3)1202; PROTEIN EP(3)3289; PROTEIN EP(3)3377; PROTEIN EP(3)3541; PROTEIN EP(3)3574; PROTEIN EP(3)3587; PROTEIN EP(3)3685; PROTEIN EP(X)1353; PROTEIN EP(X)1607; PROTEIN EP(X)1618; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DNA DAMAGE; DROSOPHILA; ENZYME ACTIVITY; GENE EXPRESSION; GENE INSERTION; GENE OVEREXPRESSION; GENETIC SCREENING; HOMOZYGOSITY; INCOMPLETE PENETRANCE; NONHUMAN; PENETRANCE; PHENOTYPE; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EYE ABNORMALITIES; G2 PHASE; GENES, INSECT; GENES, SUPPRESSOR; GENETIC SCREENING; GENOME; MUTAGENESIS, INSERTIONAL; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 58049207869     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Aihara, H., Nakagawa, T., Yasui, K., Ohta, T., Hirose, S., Dhomae, N., Takio, K., Kaneko, M., Takeshima, Y., Muramatsu, M., et al. (2004). Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. Genes Dev. 18, 877-888.
2. Anholt, R.R., Dilda, C.L., Chang, S., Fanara, J.J., Kulkarni, N.H., Ganguly, I., Rollmann, S.M., Kamdar, K.P., and Mackay, T.F. (2003). The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome. Nat. Genet. 35, 180-184.
3. Antoni, L., Sodha, N., Collins, I., and Garrett, M.D. (2007). CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? Nat. Rev. Cancer 7, 925-936.
4. Beidler, D.R., Tewari, M., Friesen, P.D., Poirier, G., and Dixit, V.M. (1995). The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis. J. Biol. Chem. 270, 16526-16528.
5. Bienz, M. (2006). The PHD finger, a nuclear protein-interaction domain. Trends Biochem. Sci. 31, 35-40.
6. Bray, S.J. (1997). Expression and function of enhancer of split bHLH proteins during Drosophila neurogenesis. Perspect. Dev. Neurobiol. 4, 313-323.
7. Brodsky, M.H., Nordstrom, W., Tsang, G., Kwan, E., Rubin, G.M., and Abrams, J.M. (2000). Drosophila p53 binds a damage response element at the reaper locus. Cell 101, 103-113.
8. Brodsky, M.H., Weinert, B.T., Tsang, G., Rong, Y.S., McGinnis, N.M., Golic, K.G., Rio, D.C., and Rubin, G.M. (2004). Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell. Biol. 24, 1219-1231.
9. Dansereau, D.A., Lunke, M.D., Finkielsztein, A., Russell, M.A., and Brook, W.J. (2002). Hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster. Development 129, 5553-5566.
10. Davis, R.L., and Turner, D.L. (2001). Vertebrate hairy and enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning. Oncogene 20, 8342-8357.
11. Dubnau, J., Chiang, A.S., Grady, L., Barditch, J., Gossweiler, S., McNeil, J., Smith, P., Buldoc, F., Scott, R., Certa, U., et al. (2003). The staufen/pumilio pathway is involved in Drosophila long-term memory. Curr. Biol. 13, 286-296.
12. Fischer, A., and Gessler, M. (2007). Delta-Notch-and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res. 35, 4583-4596.
13. Garcia-Blanco, M.A., Jamison, S.F., and Sharp, P.A. (1989). Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns. Genes Dev. 3, 1874-1886.
14. Goshima, G., Wollman, R., Goodwin, S.S., Zhang, N., Scholey, J.M., Vale, R.D., and Stuurman, N. (2007). Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316, 417-421.
15. He, X., Pool, M., Darcy, K.M., Lim, S.B., Auersperg, N., Coon, J.S., and Beck, W.T. (2007). Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene 26, 4961-4968.
16. Huang, A.M., and Rubin, G.M. (2000). A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Genetics 126, 1219-1230.
17. Hyun, J., Becam, I., Yanicostas, C., and Bohmann, D. (2006). Control of G2/M transition by Drosophila Fos. Mol. Cell. Biol. 26, 8293-8302.
18. Klose, R.J., Kallin, E.M., and Zhang, Y. (2006). JmjC-domain-containing proteins and histone demethylation. Nat. Rev. Genet. 7, 715-727.
19. Kulkarni, A., and Wilson, D.M. 3rd. (2008). The involvement of DNA-damage and -repair defects in neurological dysfunction. Am. J. Hum. Genet 82, 539-566.
20. Nichols, R.J., and Traktman, P. (2004). Characterization of three paralogous members of the mammalian vaccinia related kinase family. J. Biol. Chem. 279, 7934-7946.
21. Ollmann, M., Young, L.M., Di Como, C.J., Karim, F., Belvin, M., Robertson, S., Whittaker, K., Demsky, M., Fisher, W.W., Buchman, A., et al. (2000). Drosophila p53 is a structural and functional homolog of the tumor suppressor p53. Cell 101, 91-101.
22. Peña-Rangel, M.T., Rodriguez, I., and Riesgo-Escovar, J.R. (2002). A misexpression study examining dorsal thorax formation in Drosophila melanogaster. Genetics 160, 1035-1050.
23. Reeves, N., and Posakony, J.W. (2005). Genetic programs activated by proneural proteins in the developing Drosophila PNS. Dev. Cell 8, 413-425.
24. Rørth, P. (1996). A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc. Natl. Acad. Sci. USA 93, 12418-12422.
25. Rørth, P., Szabo, K., Bailey, A., Laverty, T., Rehm, J., Rubin, G.M., Weigmann, K., Milán, M., Benes, V., and Ansorge, W. (1998). Systematic gain-of-function genetics in Drosophila. Development 125, 1049-1057.
26. Sancar, A., Lindsey-Boltz, L.A., Unsal-Kaçmaz, K., and Linn, S. (2004). Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73, 39-85.
27. Schuettengruber, B., Chourrout, D., Vervoort, M., Leblanc, B., and Cavalli, G. (2007). Genome regulation by polycomb and trithorax proteins. Cell 128, 735-745.
28. Schultz, J., Milpetz, F., Bork, P., and Ponting, C.P. (1998). SMART, a simple modular architecture research tool: identification of signaling domains. Proc. Natl. Acad. Sci. USA 95, 5857-5864.
29. Schulz, C., Kiger, A.A., Tazuke, S.I., Yamashita, Y.M., Pantalena-Filho, L.C., Jones, D.L., Wood, C.G., and Fuller, M.T. (2004). A misexpression screen reveals effects of bag-of-marbles and TGF beta class signaling on the Drosophila male germ-line stem cell lineage. Genetics 167, 707-723.
30. Song, Y.H. (2005). Drosophila melanogaster: a model for the study of DNA damage checkpoint response. Mol. Cells 19, 167-179.
31. Song, Y.H., Mirey, G., Betson, M., Haber, D.A., and Settleman, J. (2004). The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Curr. Biol. 14, 1354-1359.
32. Spradling, A.C., Stern, D.M., Kiss, I., Roote, J., Laverty, T., and Rubin, G.M. (1995). Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. Proc. Natl. Acad. Sci. USA 92, 10824-10830.
33. Staalesen, V., Falck, J., Geisler, S., Bartkova, J., Borresen-Dale, A.L., Lukas, J., Lillehaug, J.R., Bartek, J., and Lonning, P.E. (2004). Alternative splicing and mutation status of CHEK2 in stage III breast cancer. Oncogene 23, 8535-8544.
34. Stevens, C., Smith, L., and La Thangue, N.B. (2003). Chk2 activates E2F-1 in response to DNA damage. Nat. Cell Biol. 5, 401-409.
35. Terry, N.A., Tulina, N., Matunis, E., and DiNardo, S. (2006). Novel regulators revealed by profiling Drosophila testis stem cells within their niche. Dev. Biol. 294, 246-257.
36. Tschäpe, J.A., Hammerschmied, C., Mühlig-Versen, M., Athenstaedt, K., Daum, G., and Kretzschmar, D. (2002). The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and Appl processing. EMBO J. 21, 6367-6376.
37. Valbuena, A., Vega, F.M., Blanco, S., and Lazo, P.A. (2004). p53 Stabilization and accumulation induced by human vaccinia-related kinase 1. Mol. Cell. Biol. 24, 10366-10380.
38. Wilson, R.J., Goodman, J.L., Strelets, V.B.; FlyBase Consortium. (2008). FlyBase: integration and improvements to query tools. Nucleic Acids Res. 36, D588-593.
39. Xu, J., and Du, W. (2003). Drosophila chk2 plays an important role in a mitotic checkpoint in syncytial embryos. FEBS Lett. 545, 209-212.
40. Xu, J., Xin, S., and Du, W. (2001). Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis. FEBS Lett. 508, 394-398.
41. Yang, S., Kuo, C., Bisi, J.E., and Kim, M.K. (2002). PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/ Chk2. Nat. Cell Biol. 4, 865-870.
42. Yu, X., Alder, J.K., Chun, J.H., Friedman, A.D., Heimfeld, S., Cheng, L., and Civin, C.I. (2006). HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Stem Cells 24, 876-888.