Post-translational modification of cyclin A1 is associated with staurosporine and TNFα induced apoptosis in leukemic cells

Molecular and Cellular Biochemistry

Volumn 320, Issue 1-2, 2009, Pages 115-124

  Ekberg, Jenny ^a   Persson, Jenny Liao ^a  

^a Malmö University Hospital   (Sweden)

Author keywords

Apoptosis; Cyclin A1; Post translational regulation; Staurosporine; TNF

Indexed keywords

CASPASE 3; CYCLIN A1; LACTACYSTIN; PROTEASOME; PROTEIN TYROSINE PHOSPHATASE; STAUROSPORINE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LEUKEMIA CELL; MOLECULAR DYNAMICS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN SYNTHESIS REGULATION; TWO DIMENSIONAL GEL ELECTROPHORESIS; UBIQUITINATION;

ACETYLCYSTEINE; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CASPASE 3; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CYCLIN A1; CYCLIN-DEPENDENT KINASE 2; CYSTEINE PROTEINASE INHIBITORS; ENZYME INHIBITORS; HUMANS; LEUKEMIA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; STAUROSPORINE; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITINATION;

EID: 58049162130     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9913-3     Document Type: Article

References (41)

1. 1/S transition and their response to DNA damage. FEBS Lett 490:117-122. doi: 10.1016/ S0014-5793(01)02114-7
2. Winston JT, Chu C, Harper JW (1999) Culprits in the degradation of cyclin E apprehended. Genes Dev 13:2751-2757. doi: 10.1101/gad.13.21.2751
3. Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW (1999) The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev 13:270-283. doi: 10.1101/gad.13.3.270
4. Porter PL, Malone KE, Heagerty PJ, Alexander GM, Gatti LA, Firpo EJ et al (1997) Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med 3:222-225. doi: 10.1038/nm0297-222
5. Passegue E, Jamieson CH, Ailles LE, Weissman IL (2003) Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci USA 100(Suppl 1):11842-11849. doi: 10.1073/pnas.2034201100
6. Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899-1911. doi: 10.1101/ gad.13.15.1899
7. Martinou JC, Green DR (2001) Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2:63-67. doi: 10.1038/35048069
8. Gross A et al (1999) Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 274:1156-1163. doi: 10.1074/jbc.274.2.1156
9. Gupta S (2003) Molecular signaling in death receptor and mitochondrial pathways of apoptosis. Int J Oncol 22:15-20 (Review)
10. Pucci B, Kasten M, Giordano A (2000) Cell cycle and apoptosis. Neoplasia 2:291-299. doi: 10.1038/sj.neo.7900101
11. Vermeulen K, Berneman ZN, Van Bockstaele DR (2003) Cell cycle and apoptosis. Cell Prolif 36:165-175. doi: 10.1046/j.1365-2184.2003.00267.x
12. Harvey KJ, Blomquist JF, Ucker DS (1998) Commitment and effector phases of the physiological cell death pathway elucidated with respect to Bcl-2 caspase, and cyclin-dependent kinase activities. Mol Cell Biol 18:2912-2922
13. Ling YH, Consoli U, Tornos C, Andreeff M, Perez-Soler R (1998) Accumulation of cyclin B1, activation of cyclin B1-dependent kinase and induction of programmed cell death in human epidermoid carcinoma KB cells treated with taxol. Int J Cancer 75:925-932. doi:10.1002/ (SICI)1097-0215(19980316)75:6<925::AID-IJC16>3.0.CO;2-1
14. Meikrantz W, Gisselbrecht S, Tam SW, Schlegel R (1994) Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci USA 91:3754-3758. doi: 10.1073/pnas.91.9.3754
15. Han EK, Begemann M, Sgambato A, Soh JW, Doki Y, Xing WQ et al (1996) Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis. Cell Growth Differ 7:699-710
16. Kranenburg O, van der Eb AJ, Zantema A (1996) Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J 15:46-54
17. Yang R, Muller C, Huynh V, Fung YK, Yee AS, Koeffler HP (1999) Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol Cell Biol 19:2400-2407
18. Yang R et al (1999) Cyclin A1 expression in leukemia and normal hematopoietic cells. Blood 93:2067-2074
19. Liu D, Matzuk MM, Sung WK, Guo Q, Wang P, Wolgemuth DJ (1998) Cyclin A1 is required for meiosis in the male mouse. Nat Genet 20:377-380. doi: 10.1038/3855
20. Ji P et al (2005) Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells. Oncogene 24:2739-2744. doi: 10.1038/sj.onc.1208356
21. Liao C, Wang XY, Wei HQ, Li SQ, Merghoub T, Pandolfi PP et al (2001) Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. Proc Natl Acad Sci USA 98:6853-6858. doi: 10.1073/pnas.121540098
22. Ekberg J, Holm C, Jalili S, Richter J, Anagnostaki L, Landberg G et al (2005) Expression of cyclin A1 and cell cycle proteins in hematopoietic cells and acute myeloid leukemia and links to patient outcome. Eur J Haematol 75:106-115. doi: 10.1111/j.1600-0609.2005.00473.x
23. Holm C, Ora I, Brunhoff C, Anagnostaki L, Landberg G, Persson JL (2006) Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia. Leuk Res 30:254-261. doi: 10.1016/j.leukres.2005.07.010
24. Ekberg J, Landberg G, Holm C, Richter J, Wolgemuth DJ, Persson JL (2004) Regulation of the cyclin A1 protein is associated with its differential subcellular localization in hematopoietic and leukemic cells. Oncogene 23:9082-9089. doi: 10.1038/sj.onc.1208090
25. Ekberg J, Brunhoff C, Jaras M, Fan X, Landberg G, Persson JL (2006) Increased expression of cyclin A1 protein is associated with all-trans retinoic acid-induced apoptosis. Int J Biochem Cell Biol 38:1330-1339. doi: 10.1016/j.biocel.2006.01.011
26. Glotzer M, Murray AW, Kirschner MW (1991) Cyclin is degraded by the ubiquitin pathway. Nature 349:132-138. doi: 10.1038/349132a0
27. Wallach D, Boldin M, Varfolomeev E, Beyaert R, Vandenabeele P, Fiers W (1997) Cell death induction by receptors of the TNF family: Towards a molecular understanding. FEBS Lett 410:96-106. doi: 10.1016/ S0014-5793(97)00553-X
28. 1 phase of nontransformed mammalian cells are absent in transformed cells. Proc Natl Acad Sci USA 89:8626-8630. doi: 10.1073/pnas.89.18.8626
29. Tamaoki T (1991) Use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors. Meth Enzymol 201:340-347. doi: 10.1016/0076-6879(91)01030-6
30. Edamatsu H, Gau CL, Nemoto T, Guo L, Tamanoi F (2000) Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene 19:3059-3068. doi: 10.1038/sj.onc.1203625
31. 1 - and S-phase regulators. J Cell Physiol 187:1-10. doi:10.1002/ 1097-4652(2001)9999:9999<1::AID-JCP1049>3.0.CO;2-O
32. Sudakin V, Ganoth D, Dahan A, Heller H, Hershko J, Luca FC et al (1995) The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell 6:185-197
33. Tyers M, Jorgensen P (2000) Proteolysis and the cell cycle: With this RING I do thee destroy. Curr Opin Genet Dev 10:54-64. doi: 10.1016/ S0959-437X(99)00049-0
34. Bernardi R, Pandolfi PP (2003) Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene 22:9048-9057. doi: 10.1038/sj.onc.1207106
35. Jin Y, Blue EK, Dixon S, Hou L, Wysolmerski RB, Gallagher PJ (2001) Identification of a new form of death-associated protein kinase that promotes cell survival. J Biol Chem 276:39667-39678. doi: 10.1074/ jbc.M101886200
36. Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R et al (1998) PML is essential for multiple apoptotic pathways. Nat Genet 20:266-272. doi: 10.1038/3030
37. Zhang HG, Wang J, Yang X, Hsu HC, Mountz JD (2004) Regulation of apoptosis proteins in cancer cells by ubiquitin. Oncogene 23:2009-2015. doi: 10.1038/sj.onc.1207373
38. Shimizu T, O'Connor PM, Kohn KW, Pommier Y (1995) Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage. Cancer Res 55:228-231
39. Inoue T, Geyer RK, Howard D, Yu ZK, Maki CG (2001) MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding. J Biol Chem 276:45255-45260. doi: 10.1074/jbc.M107477200
40. Shieh SY, Ikeda M, Taya Y, Prives C (1997) DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91:325-334. doi: 10.1016/S0092-8674(00)80416-X
41. Boutros R, Lobjois V, Ducommun B (2007) CDC25 phosphatases in cancer cells: Key players? Good targets? Nat Rev Cancer 7:495-507. doi: 10.1038/ nrc2169