메뉴 건너뛰기




Volumn 30, Issue 5, 2008, Pages 390-397

Iron metabolism: An overview on the main mechanisms involved in its homeostasis;Metabolismo do ferro: Uma revisão sobre os principais mecanismos envolvidos em sua homeostase

Author keywords

Anemia of chronic disease; Hepcidin; Iron deficiency anemia; Iron metabolism; Iron overload

Indexed keywords


EID: 58049145622     PISSN: 15168484     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (54)

References (40)
  • 1
    • 1842431892 scopus 로고    scopus 로고
    • Biology of heme in health and disease
    • Wijayanti N, Katz N, Immenschuh, Biology of heme in health and disease. Curr Med Chem. 2004;11(8):981-6.
    • (2004) Curr Med Chem , vol.11 , Issue.8 , pp. 981-986
    • Wijayanti, N.1    Katz, N.2    Immenschuh3
  • 2
    • 58049134879 scopus 로고    scopus 로고
    • Hoffbrand AV, Pettit FE, Moss PAH. Essential Haematology. 5th ed. Oxford (UK): Blackwell Publishing; c2006. Chapter 3, Hypochromic anaemias and iron overload; p. 28-43
    • Hoffbrand AV, Pettit FE, Moss PAH. Essential Haematology. 5th ed. Oxford (UK): Blackwell Publishing; c2006. Chapter 3, Hypochromic anaemias and iron overload; p. 28-43
  • 3
    • 1442280395 scopus 로고    scopus 로고
    • Iron metabolism
    • Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U, editors, 6th ed. New York: Mcgraw-Hill;
    • th ed. New York: Mcgraw-Hill; 2001.p. 295-304.
    • (2001) Williams-Hematology , pp. 295-304
    • Fairbanks, V.G.1    Beutler, E.2
  • 6
    • 0037623317 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of iron transport
    • Chung J, Wessling-Resnick M. Molecular mechanisms and regulation of iron transport. Crit Rev Clin Lab Sci 2003;40(2):151-82.
    • (2003) Crit Rev Clin Lab Sci , vol.40 , Issue.2 , pp. 151-182
    • Chung, J.1    Wessling-Resnick, M.2
  • 7
    • 0036800592 scopus 로고    scopus 로고
    • A genetic view of iron homeostasis
    • Andrews NC. A genetic view of iron homeostasis. Semin Hematol. 2002;39(4):227-34.
    • (2002) Semin Hematol , vol.39 , Issue.4 , pp. 227-234
    • Andrews, N.C.1
  • 8
    • 34249740700 scopus 로고    scopus 로고
    • The role of transporters in cellular heme and porphyrin homeostasis
    • Krishnamurthy P, Xie T, Schuetz JD. The role of transporters in cellular heme and porphyrin homeostasis. Pharmacol Ther. 2007; 114(3):345-58.
    • (2007) Pharmacol Ther , vol.114 , Issue.3 , pp. 345-358
    • Krishnamurthy, P.1    Xie, T.2    Schuetz, J.D.3
  • 9
    • 0742272103 scopus 로고    scopus 로고
    • The ferroportin disease
    • Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis. 2004; 32(1):131-8.
    • (2004) Blood Cells Mol Dis , vol.32 , Issue.1 , pp. 131-138
    • Pietrangelo, A.1
  • 10
    • 34248524176 scopus 로고    scopus 로고
    • The role of hepcidin and ferroportin in iron absorption
    • Oates PS. The role of hepcidin and ferroportin in iron absorption. Histol Histopathol. 2007;22(7):791-804.
    • (2007) Histol Histopathol , vol.22 , Issue.7 , pp. 791-804
    • Oates, P.S.1
  • 11
    • 33748764432 scopus 로고    scopus 로고
    • Molecular and clinical aspects of iron homeostasis: From anemia to hemochromatosis
    • Nairz M, Weiss G. Molecular and clinical aspects of iron homeostasis: From anemia to hemochromatosis. Wien Klin Wochenschr. 2006;118(15-16):442-62.
    • (2006) Wien Klin Wochenschr , vol.118 , Issue.15-16 , pp. 442-462
    • Nairz, M.1    Weiss, G.2
  • 12
    • 0037962795 scopus 로고    scopus 로고
    • The orchestration of body iron intake: How and where do enterocytes receive their cues?
    • Frazer DM, Anderson GJ. The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Mol Dis. 2003;30(3):288-97.
    • (2003) Blood Cells Mol Dis , vol.30 , Issue.3 , pp. 288-297
    • Frazer, D.M.1    Anderson, G.J.2
  • 13
    • 0037222867 scopus 로고    scopus 로고
    • Iron metabolism in the reticuloendothelial system
    • Knutson M, Wessling-Resnick M. Iron metabolism in the reticuloendothelial system. Crit Rev Biochem Mol Biol. 2003;38 (1):61-88.
    • (2003) Crit Rev Biochem Mol Biol , vol.38 , Issue.1 , pp. 61-88
    • Knutson, M.1    Wessling-Resnick, M.2
  • 14
    • 0031963449 scopus 로고    scopus 로고
    • Function and regulation of transferrin and ferritin
    • Ponka P, Beaumont C, Richardson DR. Function and regulation of transferrin and ferritin. Semin Hematol. 1998;35(1);35-54.
    • (1998) Semin Hematol , vol.35 , Issue.1 , pp. 35-54
    • Ponka, P.1    Beaumont, C.2    Richardson, D.R.3
  • 15
    • 0036264265 scopus 로고    scopus 로고
    • Serum transferrin receptor assays and their application
    • Worwood M. Serum transferrin receptor assays and their application. Ann Clin Biochem. 2002;39(Pt 3):221-30.
    • (2002) Ann Clin Biochem , vol.39 , Issue.PART 3 , pp. 221-230
    • Worwood, M.1
  • 16
    • 0029880903 scopus 로고    scopus 로고
    • Assessment of iron status
    • Baynes RD. Assessment of iron status. Clin Biochem. 1996;29 (3):209-15
    • (1996) Clin Biochem , vol.29 , Issue.3 , pp. 209-215
    • Baynes, R.D.1
  • 17
    • 27644455133 scopus 로고    scopus 로고
    • Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
    • Ohgami RS, Campagna DR, Greer EL, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet. 2005;37(11):1264-9.
    • (2005) Nat Genet , vol.37 , Issue.11 , pp. 1264-1269
    • Ohgami, R.S.1    Campagna, D.R.2    Greer, E.L.3
  • 18
    • 0026546708 scopus 로고
    • The soluble transferrin receptor; biological aspects and clinical usefulness as quantitative measure of erythropoiesis
    • Beguin Y. The soluble transferrin receptor; biological aspects and clinical usefulness as quantitative measure of erythropoiesis. Haematologica. 1992;77(1):1-10.
    • (1992) Haematologica , vol.77 , Issue.1 , pp. 1-10
    • Beguin, Y.1
  • 19
    • 0025271562 scopus 로고
    • Serum transferrin receptor: A quantitative measure of tissue iron deficiency
    • Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood. 1990; 75 (9):1870-6.
    • (1990) Blood , vol.75 , Issue.9 , pp. 1870-1876
    • Skikne, B.S.1    Flowers, C.H.2    Cook, J.D.3
  • 20
    • 0033597780 scopus 로고    scopus 로고
    • Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family
    • Jul 23;
    • Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, el al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem. 1999 Jul 23;274(30):20826-32.
    • (1999) J Biol Chem , vol.274 , Issue.30 , pp. 20826-20832
    • Kawabata, H.1    Yang, R.2    Hirama, T.3    Vuong, P.T.4    Kawano, S.5    Gombart, A.F.6    el al7
  • 22
    • 33846691564 scopus 로고    scopus 로고
    • Iron uptake and metabolism in the new millennium
    • Dunn LL, Rahmanto YS, Richardson DR. Iron uptake and metabolism in the new millennium. Trends Cell Biol. 2007;17 (2): 93-100.
    • (2007) Trends Cell Biol , vol.17 , Issue.2 , pp. 93-100
    • Dunn, L.L.1    Rahmanto, Y.S.2    Richardson, D.R.3
  • 23
    • 34248149391 scopus 로고    scopus 로고
    • Friedreich's ataxia: Coenzyme Q10 and vitamin E therapy
    • Cooper JM, Schapira AH. Friedreich's ataxia: coenzyme Q10 and vitamin E therapy. Mitochondrion. 2007;7 (Suppl 1):S127-35.
    • (2007) Mitochondrion , vol.7 , Issue.SUPPL. 1
    • Cooper, J.M.1    Schapira, A.H.2
  • 24
    • 0036118773 scopus 로고    scopus 로고
    • Sideroblastic anaemias
    • Alcindor T, Bridges KR. Sideroblastic anaemias. Br J Haematol. 2002;116(4):733-43.
    • (2002) Br J Haematol , vol.116 , Issue.4 , pp. 733-743
    • Alcindor, T.1    Bridges, K.R.2
  • 25
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001; 276(11):7806-10.
    • (2001) J Biol Chem , vol.276 , Issue.11 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 26
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-I, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Mägert HJ, et al. LEAP-I, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000;480(2-3):147-50
    • (2000) FEBS Lett , vol.480 , Issue.2-3 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Mägert, H.J.3
  • 27
    • 0037007064 scopus 로고    scopus 로고
    • Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
    • Apr 2;
    • Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA. 2002 Apr 2;99(7):4596-601.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.7 , pp. 4596-4601
    • Nicolas, G.1    Bennoun, M.2    Porteu, A.3
  • 28
    • 33644862202 scopus 로고    scopus 로고
    • Iron imports. IV. Hepcidin and regulation of body iron metabolism
    • Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006;290(2):G199-203.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , Issue.2
    • Ganz, T.1    Nemeth, E.2
  • 29
    • 14544298717 scopus 로고    scopus 로고
    • Hepcidin - a regulator of intestinal iron absorption and iron recycling by macrophages
    • Ganz T. Hepcidin - a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol. 2005;18(2):171-82
    • (2005) Best Pract Res Clin Haematol , vol.18 , Issue.2 , pp. 171-182
    • Ganz, T.1
  • 30
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113(9):1271-6.
    • (2004) J Clin Invest , vol.113 , Issue.9 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6
  • 31
    • 13544252463 scopus 로고    scopus 로고
    • Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
    • Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood. 2005;105(4):1797-802.
    • (2005) Blood , vol.105 , Issue.4 , pp. 1797-1802
    • Rivera, S.1    Liu, L.2    Nemeth, E.3    Gabayan, V.4    Sorensen, O.E.5    Ganz, T.6
  • 32
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306 (5704):2090-3.
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 33
    • 34447117474 scopus 로고    scopus 로고
    • Hepcidin regulation: Ironing out the details
    • De Domenico I, Ward DM, Kaplan J. Hepcidin regulation: ironing out the details. J Clin Invest. 2007;117(7):1755-8.
    • (2007) J Clin Invest , vol.117 , Issue.7 , pp. 1755-1758
    • De Domenico, I.1    Ward, D.M.2    Kaplan, J.3
  • 35
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108(9):3204-9.
    • (2006) Blood , vol.108 , Issue.9 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 36
    • 33845985236 scopus 로고    scopus 로고
    • STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
    • Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, et al. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 2007; 109(1):353-8
    • (2007) Blood , vol.109 , Issue.1 , pp. 353-358
    • Verga Falzacappa, M.V.1    Vujic Spasic, M.2    Kessler, R.3    Stolte, J.4    Hentze, M.W.5
  • 37
    • 23444439528 scopus 로고    scopus 로고
    • Systemic regulation of intestinal iron absorption
    • Steele TM, Frazer DM, Anderson GJ. Systemic regulation of intestinal iron absorption. IUBMB Life. 2005;57(7):499-503.
    • (2005) IUBMB Life , vol.57 , Issue.7 , pp. 499-503
    • Steele, T.M.1    Frazer, D.M.2    Anderson, G.J.3
  • 38
    • 14544294358 scopus 로고    scopus 로고
    • Modification of iron regulation by the inflammatory response
    • Weiss G. Modification of iron regulation by the inflammatory response. Best Pract Res Clin Haematol. 2005;18(2):183-201.
    • (2005) Best Pract Res Clin Haematol , vol.18 , Issue.2 , pp. 183-201
    • Weiss, G.1
  • 39
    • 42949127743 scopus 로고    scopus 로고
    • Anaemia of cancer: An overview of mechanisms involved in its pathogenesis
    • DOI 10.1007/S12032-007-9000-8
    • Grotto HZW. Anaemia of cancer: an overview of mechanisms involved in its pathogenesis. Med Oncol. 2007, DOI 10.1007/S12032-007-9000-8.
    • Med Oncol , vol.2007
    • Grotto, H.Z.W.1
  • 40
    • 0036308047 scopus 로고    scopus 로고
    • Pathogenesis and treatment of anaemia of chronic disease
    • Weiss G. Pathogenesis and treatment of anaemia of chronic disease. Blood Rev. 2002;16(2):87-96.
    • (2002) Blood Rev , vol.16 , Issue.2 , pp. 87-96
    • Weiss, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.