Inhibition of the complete set of mammalian secreted phospholipases A 2 by indole analogues: A structure-guided study

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 7, 2004, Pages 1737-1749

  Smart, Brian P ^a   Pan, Ying H ^b   Weeks, Amanda K ^a   Bollinger, James G ^a   Bahnson, Brian J ^b   Gelb, Michael H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[[3 [AMINO(OXO)ACETYL] 1 (BIPHENYL 2 YLMETHYL) 2 METHYL 1H INDOL 4 YL]OXY]ACETIC ACID; INDOLE DERIVATIVE; PHOSPHOLIPASE A2; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME RELEASE; IC 50; MAMMAL; STRUCTURAL HOMOLOGY; SUBSTITUTION REACTION; X RAY ANALYSIS;

ANIMALS; CARBAMATES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDOLES; INDOLIZINES; MICE; MOLECULAR STRUCTURE; PHOSPHOLIPASES A; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 1542613782     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.01.022     Document Type: Article

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