Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia

Reproductive Sciences

Volumn 15, Issue 10, 2008, Pages 1034-1043

  Heazell, Alexander E P ^a   Buttle, Hilary R ^a   Baker, Philip N ^a   Crocker, Ian P ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Inhibitors of apoptosis proteins; Placenta; Pre eclampsia; Smac; Villous trophoblast

Indexed keywords

CASPASE; INHIBITOR OF APOPTOSIS PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SERINE PROTEINASE OMI; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS;

ADULT; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTROPHOBLAST; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; HUMAN; HUMAN TISSUE; PLACENTA; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SYNCYTIOTROPHOBLAST; BIOSYNTHESIS; COMPARATIVE STUDY; CYTOLOGY; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; METABOLISM; NEWBORN; PATHOLOGY; PHYSIOLOGY; TROPHOBLAST; YOUNG ADULT;

ADULT; APOPTOSIS; CASPASES; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INFANT, NEWBORN; PRE-ECLAMPSIA; PREGNANCY; TROPHOBLASTS; YOUNG ADULT;

EID: 57849155828     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719108322438     Document Type: Article

References (31)

1. Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA Placental apoptosis in preeclampsia. Obstet Gynecol. 2000 ; 96: 271-276.
2. Leung DN, Smith SC, To KF, Sahota DS, Baker PN Increased placental apoptosis in pregnancies complicated by preeclampsia. Am J Obstet Gynecol. 2001 ; 184: 1249-1250.
3. Ishihara N., Matsuo H., Murakoshi H., Laoag-Fernandez JB, Samoto T., Maruo T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol. 2002 ; 186: 158-166.
4. Heazell AE, Moll SJ, Jones CJ, Baker PN, Crocker IP Formation of syncytial knots is increased by hyperoxia, hypoxia and reactive oxygen species. Placenta. 2007 ; 28 (suppl 1). S33 - S40.
5. Johansen M., Redman CW, Wilkins T., Sargent IL Trophoblast deportation in human pregnancy-its relevance for pre-eclampsia. Placenta. 1999 ; 20: 531-539.
6. Hung TH, Skepper JN, Charnock-Jones DS, Burton GJ Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res. 2002 ; 90: 1274-1281.
7. Levy R., Smith SD, Chandler K., Sadovsky Y., Nelson DM Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor. Am J Physiol Cell Physiol. 2000 ; 278: C982 - C988.
8. Donovan M., Cotter TG Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Biochim Biophys Acta. 2004 ; 1644: 133-147.
9. Nicholson DW, Thornberry NA Apoptosis. Life and death decisions. Science. 2003 ; 299: 214-215.
10. Crocker IP, Brown LM, Heazell AEP, Baker PN The expression and activities of pivotal placental caspases in pregnancies complicated by pre-eclampsia and intra-uterine growth restriction. J Soc Gynecol Investig. 2005 ; 12: 197A.
11. Huppertz B., Kingdom J., Caniggia I., et al. Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation. Placenta. 2003 ; 24: 181-190.
12. Ka H., Hunt JS Temporal and spatial patterns of expression of inhibitors of apoptosis in human placentas. Am J Pathol. 2003 ; 163: 413-422.
13. Holcik M., Gibson H., Korneluk RG XIAP: apoptotic brake and promising therapeutic target. Apoptosis. 2001 ; 6: 253-261.
14. Wheatley SP, McNeish IA Survivin: a protein with dual roles in mitosis and apoptosis. Int Rev Cytol. 2005 ; 247: 35-88.
15. Davoodi J., Lin L., Kelly J., Liston P., MacKenzie AE Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. J Biol Chem. 2004 ; 279: 40622-40628.
16. Verhagen AM, Ekert PG, Pakusch M., et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000 ; 102: 43-53.
17. Saelens X., Festjens N., Vande Walle L., van Gurp M., van Loo G., Vandenabeele P. Toxic proteins released from mitochondria in cell death. Oncogene. 2004 ; 23: 2861-2874.
18. Davey DA, MacGillivray I. The classification and definition of the hypertensive disorders of pregnancy. Am J Obstet Gynecol. 1988 ; 158: 892-898.
19. Crocker IP, Daayana SL, Baker PN An image analysis technique for the investigation of human placental morphology in pre-eclampsia and intrauterine growth restriction. J Soc Gynecol Investig. 2004 ; 11: 545-552.
20. Maddox PH, Jenkins D. 3-Aminopropyltriethoxysilane (APES): a new advance in section adhesion. J Clin Pathol. 1987 ; 40: 1256-1257.
21. Chai J., Du C., Wu JW, Kyin S., Wang X., Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 2000 ; 406: 855-862.
22. Gruslin A., Qiu Q., Tsang BK X-linked inhibitor of apoptosis protein expression and the regulation of apoptosis during human placental development. Biol Reprod. 2001 ; 64: 1264-1272.
23. Shiozaki A., Kataoka K., Fujimura M., Yuki H., Sakai M., Saito S. Survivin inhibits apoptosis in cytotrophoblasts. Placenta. 2003 ; 24: 65-76.
24. Sakuragi N., Matsuo H., Coukos G., et al. Differentiation-dependent expression of the BCL-2 proto-oncogene in the human trophoblast lineage. J Soc Gynecol Investig. 1994 ; 1: 164-172.
25. Fulop V., Mok SC, Genest DR, Gati I., Doszpod J., Berkowitz RS p 53, p 21, Rb and mdm2 oncoproteins. Expression in normal placenta, partial and complete mole, and choriocarcinoma. J Reprod Med. 1998 ; 43: 119-127.
26. Huppertz B., Frank HG, Kingdom JC, Reister F., Kaufmann P. Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta. Histochem Cell Biol. 1998 ; 110: 495-508.
27. Harlin H., Reffey SB, Duckett CS, Lindsten T., Thompson CB Characterization of XIAP-deficient mice. Mol Cell Biol. 2001 ; 21: 3604-3608.
28. Okada H., Suh WK, Jin J., et al. Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol. 2002 ; 22: 3509-3517.
29. Du C., Fang M., Li Y., Li L., Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000 ; 102: 33-42.
30. Heazell AE, Brown LM, Crocker IP, Baker PN Expression of Oncoproteins p53, BAK and p21 in normal pregnancies and those complicated by pre-eclampsia. Placenta. 2005 ; 26: A59.
31. Crocker IP, Cooper S., Ong SC, Baker PN Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction. Am J Pathol. 2003 ; 162: 637-643.