Hypoxia-reoxygenation: A potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia

Circulation Research

Volumn 90, Issue 12, 2002, Pages 1274-1281

  Hung, Tai Ho ^a   Skepper, Jeremy N ^a   Charnock Jones, D Stephen ^a   Burton, Graham J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apoptosis ischemia reperfusion; Injury; Oxidative stress; Placenta; Preeclampsia

Indexed keywords

CASPASE 3; CYTOCHROME C; DEFEROXAMINE; HYDROXYL RADICAL; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MITOCHONDRION; NICK END LABELING; OXIDATIVE STRESS; PLACENTA CIRCULATION; PLACENTA VILLUS; PREECLAMPSIA; PRIORITY JOURNAL; REOXYGENATION; REPERFUSION INJURY; SYNCYTIOTROPHOBLAST; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

APOPTOSIS; CASPASE 3; CASPASES; CELL HYPOXIA; CELL NUCLEUS; CHORIONIC VILLI; CULTURE TECHNIQUES; CYTOCHROME C GROUP; DEFEROXAMINE; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; IN SITU NICK-END LABELING; MITOCHONDRIA; OXIDATIVE STRESS; PLACENTA; POLY(ADP-RIBOSE) POLYMERASES; PRE-ECLAMPSIA; PREGNANCY; REPERFUSION INJURY;

EID: 0037188944     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000024411.22110.AA     Document Type: Article

References (36)

1. Oxidative stress in the pathogenesis of preeclampsia
2. Is oxidative stress the link in the two-stage model of pre-eclampsia?
3. Placental debris, oxidative stress and preeclampsia
4. Blood gases in pregnancy at sea level and at high altitude
5. Influence of oxygen supply on placental structure
6. In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies
7. Nitrotyrosine residues in placenta: Evidence of peroxynitrite formation and action
8. Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia
9. Placental apoptosis in preeclampsia
10. Increased placental apoptosis in pregnancies complicated by preeclampsia
11. 4-Hydroxynonenal induces dysfunction and apoptosis of cultured endothelial cells
12. Oxidative stress-induced apoptosis of endothelial cells
13. Signalling apoptosis: A radical approach
14. Apoptosis in RAW264.7 cells exposed to 4-hydroxy-2-nonenal: Dependence on cytochrome c release but not p53 accumulation
15. Apoptosis in ischaemia-reperfusion injury
16. Oxygen is a toxic gas: An introduction to oxygen toxicity and reactive oxygen species
17. Effect of gestational age on fetal and intervillous blood gas and acid-base values in human pregnancy
18. Blood gas analysis of placental and uterine blood during cesarean delivery
19. Susceptibility of human placental syncytiotrophoblastic mitochondria to oxygen-mediated damage in relation to gestational age
20. Placental oxygen consumption. Part II: In vitro studies-a review
21. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies
22. Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury
23. Hyperuricemia and xanthine oxidase in preeclampsia, revisited
24. The versatility and universality of calcium signalling
25. Mitochondrial intermembrane junctional complexes and their role in cell death
26. Mitochondrial permeability transition and oxidative stress
27. Caspases: The executioners of apoptosis
28. Apoptosis, oncosis, and necrosis: An overview of cell death
29. Organelle-specific initiation of cell death pathways
30. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
31. Trophoblast deportation in pre-eclamptic pregnancy
32. Quantitative analysis of fetal DNA in maternal plasma and serum: Implications for noninvasive prenatal diagnosis
33. Levels of dimethylarginines and cytokines in mild and severe preeclampsia
34. Does ADMA cause endothelial dysfunction
35. The utero-placental vessels at term: The distribution and extent of physiological changes
36. Intermittent functioning of the uteroplacental arteries