p53, p21, Rb and mdm2 oncoproteins: Expression in normal placenta, partial and complete mole, and choriocarcinoma

Journal of Reproductive Medicine for the Obstetrician and Gynecologist

Volumn 43, Issue 2, 1998, Pages 119-127

  Fulop, Vilmos ^b   Mok, Samuel C ^b   Genest, David R ^b   Gati, Istvan ^b   Doszpod, Jozsef ^b   Berkowitz, Ross S ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NONE

Author keywords

Choriocarcinoma; p53 Protein; Tropholastic tumor

Indexed keywords

DNA; ONCOPROTEIN; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ARTICLE; CHORIOCARCINOMA; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; PATHOGENESIS; PLACENTA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE STRAND CONFORMATION POLYMORPHISM;

CHORIOCARCINOMA; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FEMALE; GENES, P53; HUMANS; HYDATIDIFORM MOLE; IMMUNOENZYME TECHNIQUES; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PLACENTA; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PREGNANCY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53; UTERINE NEOPLASMS;

EID: 0031914271     PISSN: 00247758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Hancock BW, Newlands ES, Berkowitz RS: Gestational Trophoblastic Disease. Cambridge, University Press, 1997, pp 1-143
2. Hollstein M, Sidransky D, Vogelstein B, et al: p53 Mutations in human cancers. Science 1991;253:49-53
3. Finlay CA: The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol Cell Biol 1993;13:301-306
4. Barak Y, Juven T, Haffner R, et al: mdm-2 Expression is induced by wild type p53 activity. EMBO J 1993;12:461-468
5. Haines DS, Landers JE, Engle LJ: Physical and functional interaction between wild-type p53 and mdm2 proteins. Mol Cell Biol 1994;14:1171-1178
6. Steinman RA, Hoffman B, Iro A, et al: Induction of p21 (WAF1/CIP1) during differentiation. Oncogene 1994;9: 3389-3396
7. Harper JW, Adami GR, Wei N, et al: The p21 cdk-interacting protein dpi is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993;75:805-816
8. Mutter GL, Chaponot ML, Fletcher JA: A polymerase chain reaction assay for nonrandom X chromosome inactivation identifies monoclonal endometrial cancers and precancers. Am J Pathol 1995;146:501-508
9. Landers JE, Haines DS, Strauss JF, et al: Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene 1994;9: 2745-2750
10. Momand J, Zambetti GP, Olson DC, et al: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237-1245
11. Wu X, Bayle JH, Olson D, el al: The p53-mdm-2 autoregulatory feedback loop. Genes Dev 1993;7:1126-1132
12. Cheung ANY, Srivastava G, Chung LP, et al: Expression of the p53 gene in trophoblastic cells in hydatidiform moles and normal human placentas. J Reprod Med 1994;39: 223-227
13. Cordon-Cardo C, Latres E, Drobnjak M, et al: Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 1994;54:794-799
14. Reifenberger G, Liu L, Ichimura K, et al: Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 1993; 53:2736-2739
15. Xiao Z-X, Chen J, Levine AJ, et al: Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 1995;375:694-697
16. Shimizu T, Miwa W, Nakamori S, et al: Absence of a mutation of the p21/WAF1 gene in human lung and pancreatic cancers. Jpn J Cancer Res 1996;87:275-278
17. Steller MA, Mok SC, Yeh J, et al: Effects of cytokines on epidermal growth factor receptor expression by malignant trophoblast cells in vitro. J Reprod Med 1994;39:209-216
18. Maruo T, Mochizuki M: Immunohistochemical localization of epidermal growth factor receptor and myc oncogene product in human placenta: Implication for trophoblast proliferation and differentiation. Am J Obstet Gynecol 1987;156: 721-727
19. Hampson J, McLaughlin PJ, Johnson PM: Low affinity receptors for tumor necrosis factor-alpha, interferon-gamma and granulocyte-macrophage colony-stimulating factor are expressed on human placental syncytiotrophoblast. Immunology 1993;79:485-490
20. Ferriani RA, Ahmed A, Sharkey A, et al: Colocalization of acidic and basic fibroblast growth factor (FGF) in human placenta and the cellular effects of bFGF in trophoblast cell line JEG-3. Growth Factors 1994;10:259-268