A functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderly

Behavior Genetics

Volumn 39, Issue 1, 2009, Pages 15-23

  Bochdanovits, Zoltán ^a   Gosso, Florencia M ^a,b   Van Den Berg, Linda ^a   Rizzu, Patrizia ^a,b   Polderman, Tinca J C ^b,c   Pardo, Luba M ^a,b   Houlihan, Lorna M ^d   Luciano, Michelle ^d   Starr, John M ^d   Harris, Sarah E ^d   Deary, Ian J ^d   De Geus, Eco J C ^b   Boomsma, Dorret I ^a,b   Heutink, Peter ^a,b   Posthuma, Danielle ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Comparative genomics; Functional polymorphism; Genetic association; Human evolution; IQ

Indexed keywords

AMINO ACID; BETA 2 ADRENERGIC RECEPTOR;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BEHAVIOR; CHILD; CHIMPANZEE; COGNITION; COMPARATIVE GENOMIC HYBRIDIZATION; EVOLUTION; GENETIC ASSOCIATION; GENETIC SELECTION; GENETIC TRAIT; GENETIC VARIABILITY; HUMAN; INTELLIGENCE; INTELLIGENCE QUOTIENT; MEMORY CONSOLIDATION; NONHUMAN; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGING; ANIMALS; BRAIN; CHILD; EVOLUTION, MOLECULAR; FAMILY; FEMALE; GENOME, HUMAN; HUMANS; INTELLIGENCE; MALE; PAN TROGLODYTES; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PRIMATES; PROTEINS; RECEPTORS, ADRENERGIC, BETA-2; REGRESSION ANALYSIS; RODENTIA; SELECTION (GENETICS);

PAN; PRIMATES;

EID: 57849149001     PISSN: 00018244     EISSN: 15733297     Source Type: Journal    
DOI: 10.1007/s10519-008-9233-0     Document Type: Article

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