Selective Pressures at a Codon-level Predict Deleterious Mutations in Human Disease Genes

Journal of Molecular Biology

Volumn 358, Issue 5, 2006, Pages 1390-1404

  Arbiza, Leonardo ^a   Duchi, Serena ^a   Montaner, David ^a   Burguet, Jordi ^a   Pantoja Uceda, David ^a   Pineda Lucena, Antonio ^a   Dopazo, Joaquín ^a   Dopazo, Hernán ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

codon based models; comparative genomics; deleterious mutations; human diseases; purifying selection

Indexed keywords

DNA; PROTEIN P53;

ARTICLE; CODON; DISEASE ASSOCIATION; GENE MUTATION; GENETIC CODE; GENOMICS; HUMAN; HYPOTHESIS; MODEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRESSURE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RAT; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

EID: 33646488359     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.02.067     Document Type: Article

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