Pet studies of serotonin synthesis in the human brain

Advances in Experimental Medicine and Biology

Volumn 467, Issue , 2000, Pages 11-18

  Young, S N ^a   Leyton, M ^a   Benkelfat, C ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA METHYLSEROTONIN; AMINE OXIDASE (FLAVIN CONTAINING); CARBON 11; N METHYLTRYPTOPHAN; SEROTONIN;

AFFECTIVE NEUROSIS; AMINO ACID BLOOD LEVEL; BORDERLINE STATE; CONFERENCE PAPER; HORMONE SYNTHESIS; HUMAN; IMPULSIVENESS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SEX DIFFERENCE;

BRAIN; CARBON RADIOISOTOPES; FEMALE; HUMANS; MALE; PERSONALITY DISORDERS; RADIOPHARMACEUTICALS; SEROTONIN; SEX CHARACTERISTICS; TOMOGRAPHY, EMISSION-COMPUTED; TRYPTOPHAN;

EID: 0034468545     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (42)

1. 11C]5-hydroxytryptophan in major depression: A positron emission tomography study on patients and healthy volunteers
2. Dieting reduces plasma tryptophan and alters brain 5-HT function in women
3. Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse
4. Toward a unified theory of serotonin dysregulation in eating and related disorders
5. 11C]methyl-L-tryptophan
6. Serotonin concentrations and turnover in brains of depressed suicides
7. Evidence α[C-11]methyl-L-tryptophan metabolism via the kynurenine pathway in tuberous sclerosis complex
8. Human brain serotonin synthesis capacity measured in vivo with α-[C-11]methyl-L-tryptophan
9. The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects
10. 3H]paroxetine
11. Unesterified fatty acids and the binding of tryptophan in human plasma
12. 2 receptors and the serotonin transporter in the schizophrenic brain
13. Serotonin function and the mechanism of antidepressant action: Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan
14. A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model
15. Mood response to acute tryptophan depletion in healthy volunteers: Sex differences and temporal stability
16. Monoamine metabolites in lumbar CSF: Their sites of origin in relation to clinical studies
17. Indoleamines: The role of serotonin in clinical disorders
18. Serotonin, sex, and psychiatric illness
19. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease
20. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics
21. PET with hydroxytryptophan as tracer in hormone-refractory prostatic adenocarcinoma: Evaluation of decarboxylation in vivo
22. Female rats are more vulnerable than males in an animal model of depression: The possible role of serotonin
23. 3H]paroxetine binding, a marker of serotonin uptake sites
24. Metabolism of a-methyltryptophan
25. Functional cerebral activity of an analogue of serotonin formed in situ
26. Tryptophan depletion and aggressive responding in healthy males
27. Non-invasive in-vivo autoradiographic method to measure axonal transport in serotoninergic neurons in the rat brain
28. A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium-treated rats
29. The tryptophan depletion test: Basic principles and clinical relevance
30. Differences between males and females in rates of serotonin synthesis in human brain
31. Regional rates of brain serotonin synthesis in patients with borderline personality disorder vs obsessive-compulsive disorder: Analyses with statistical parametric mapping
32. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data: Generalizations
33. Acute effect of altered tryptophan levels and alcohol on aggression in normal human males
34. Rapid depletion of plasma tryptophan: A review of studies and experimental methodology
35. Pharmacokinetics of α-methyl-L-tryptophan in rhesus monkeys and calculation of the lumped constant for estimating the rate of serotonin synthesis
36. 11C]α-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindoleo-3-acetic acid concentrations
37. 14C]deoxyglucose method the the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat
38. Alpha-methyltryptophan and its actions on tryptophan metabolism
39. Anxiety and aggression as pacemakers of depression: A dimensional variation of the serotonin hypothesis of depression
40. Determination of the lumped constant for the alpha-methyltryptophan method of estimating the rate of serotonin synthesis
41. Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder
42. Tryptophan depletion causes a rapid lowering of mood in normal males