Differential induction of MyD88- and TRIF-dependent pathways in equine monocytes by Toll-like receptor agonists

Veterinary Immunology and Immunopathology

Volumn 127, Issue 1-2, 2009, Pages 125-134

  Figueiredo, Monica D ^a   Vandenplas, Michel L ^a   Hurley, David J ^a   Moore, James N ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Equine; Microbial ligands; Monocytes; mRNA expression; Toll like receptors

Indexed keywords

BETA INTERFERON; INTERLEUKIN 10; MYELOID DIFFERENTIATION FACTOR 88; RANTES; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; HORSE; MONOCYTE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BASE SEQUENCE; CHEMOKINE CCL5; CHEMOKINE CXCL10; CYTOKINES; DNA PRIMERS; GENE EXPRESSION PROFILING; HORSES; INTERFERON-GAMMA; LIGANDS; LIPOPEPTIDES; LIPOPOLYSACCHARIDES; MONOCYTES; MYELOID DIFFERENTIATION FACTOR 88; POLY I-C; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EQUIDAE; ESCHERICHIA COLI;

EID: 57749200716     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.09.028     Document Type: Article

References (51)

1. Akira S., and Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4 (2004) 499-511
2. Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 (2001) 732-738
3. Allen C.A., Payne S.L., Harville M., Cohen N., and Russell K.E. Validation of quantitative polymerase chain reaction assays for measuring cytokine expression in equine macrophages. J. Immunol. Methods 328 (2007) 59-69
4. Amati L., Pepe M., Passeri M.E., Mastronardi M.L., Jirillo E., and Covelli V. Toll-like receptor signaling mechanisms involved in dendritic cell activation: potential therapeutic control of T cell polarization. Curr. Pharm. Des. 12 (2006) 4247-4254
5. Bas A., Forsberg G., Hammarstrom S., and Hammarstrom M.L. Utility of the housekeeping genes 18S rRNA, beta-actin and glyceraldehyde-3-phosphate-dehydrogenase for normalization in real-time quantitative reverse transcriptase-polymerase chain reaction analysis of gene expression in human T lymphocytes. Scand. J. Immunol. 59 (2004) 566-573
6. Berndt A., Derksen F.J., Venta P.J., Ewart S., Yuzbasiyan-Gurkan V., and Robinson N.E. Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction. Am. J. Physiol. Lung Cell. Mol. Physiol. 292 (2007) L936-L943
7. Bjorkbacka H., Fitzgerald K.A., Huet F., Li X., Gregory J.A., Lee M.A., Ordija C.M., Dowley N.E., Golenbock D.T., and Freeman M.W. The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol. Genomics 19 (2004) 319-330
8. Campa V.M., Iglesias J.M., Carcedo M.T., Rodriguez R., Riera J., Ramos S., and Lazo P.S. Polyinosinic acid induces TNF and NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7. Inflamm. Res. 54 (2005) 328-337
9. Constantin C.E., Mair N., Sailer C.A., Andratsch M., Xu Z.Z., Blumer M.J., Scherbakov N., Davis J.B., Bluethmann H., Ji R.R., and Kress M. Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. J. Neurosci. 28 (2008) 5072-5081
10. Dabbagh K., and Lewis D.B. Toll-like receptors and T-helper-1/T-helper-2 responses. Curr. Opin. Infect. Dis. 16 (2003) 199-204
11. Dechend R., Maass M., Gieffers J., Dietz R., Scheidereit C., Leutz A., and Gulba D.C. Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression: a potential link to accelerated arteriosclerosis. Circulation 100 (1999) 1369-1373
12. Figueiredo M.D., Moore J.N., Vandenplas M.L., Sun W.C., and Murray T.F. Effects of the second-generation synthetic lipid A analogue E5564 on responses to endotoxin equine whole blood and monocytes. Am. J. Vet. Res. 69 (2008) 796-803
13. Figueiredo M.D., Salter C.E., Hurley D.J., and Moore J.N. A comparison of equine and bovine sera as sources of lipopolysaccharide-binding protein activity in equine monocytes incubated with lipopolysaccharide. Vet. Immunol. Immunopathol. 121 (2008) 275-280
14. Flaminio M.J., Borges A.S., Nydam D.V., Horohov D.W., Hecker R., and Matychak M.B. The effect of CpG-ODN on antigen presenting cells of the foal. J. Immun. Based Ther. Vaccines 5 (2007) 1
15. Gandhi R., Hayley S., Gibb J., Merali Z., and Anisman H. Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors. Brain Behav. Immun. 21 (2007) 477-489
16. Gold J.R., Perkins G.A., Erb H.N., and Ainsworth D.M. Cytokine profiles of peripheral blood mononuclear cells isolated from septic and healthy neonatal foals. J. Vet. Intern. Med. 21 (2007) 482-488
17. Hargreaves D.C., and Medzhitov R. Innate sensors of microbial infection. J. Clin. Immunol. 25 (2005) 503-510
18. Henry M.M., and Moore J.N. Endotoxin-induced procoagulant activity in equine peripheral blood monocytes. Circ. Shock 26 (1988) 297-309
19. Hirotani T., Yamamoto M., Kumagai Y., Uematsu S., Kawase I., Takeuchi O., and Akira S. Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta. Biochem. Biophys. Res. Commun. 328 (2005) 383-392
20. Itai T., Tanaka M., and Nagata S. Processing of tumor necrosis factor by the membrane-bound TNF-alpha-converting enzyme, but not its truncated soluble form. Eur. J. Biochem. 268 (2001) 2074-2082
21. Iwaki D., Mitsuzawa H., Murakami S., Sano H., Konishi M., Akino T., and Kuroki Y. The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J. Biol. Chem. 277 (2002) 24315-24320
22. Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5 (2004) 987-995
23. Kawai T., Takeuchi O., Fujita T., Inoue J., Muhlradt P.F., Sato S., Hoshino K., and Akira S. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167 (2001) 5887-5894
24. Lee N.K., and Lee S.Y. Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs). J. Biochem. Mol. Biol. 35 (2002) 61-66
25. McGeachy M., Bell A., Keowen M.L., Peiro J., and Stokes A.M. Alterations in toll-like receptor regulation in the liver from horses with laminitis. Proc. FASEB J. 22 (2008) 1190-1198
26. McWhirter S.M., Fitzgerald K.A., Rosains J., Rowe D.C., Golenbock D.T., and Maniatis T. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 233-238
27. Moore J.N., and Morris D.D. Endotoxemia and septicemia in horses: experimental and clinical correlates. J. Am. Vet. Med. Assoc. 200 (1992) 1903-1914
28. Morris D.D. Endotoxemia in horses. A review of cellular and humoral mediators involved in its pathogenesis. J. Vet. Intern. Med. 5 (1991) 167-181
29. Morrison D.C., and Jacobs D.M. Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry 13 (1976) 813-818
30. Musilova P., Kubickova S., Vychodilova-Krenkova L., Kralik P., Matiasovic J., Hubertova D., Rubes J., and Horin P. Cytogenetic mapping of immunity-related genes in the domestic horse. Anim. Genet. 36 (2005) 507-510
31. O'Neill L.A. How Toll-like receptors signal: what we know and what we don't know. Curr. Opin. Immunol. 18 (2006) 3-9
32. Okano S., Hurley D.J., Bergh M.S., Vandenplas M.L., Budsberg S.C., and Moore J.N. Optimization of conditions for in vitro production of radical oxygen species and expression of tissue factor by canine mononuclear cells and granulocytes for use in high-throughput assays. Vet. Immunol. Immunopathol. 112 (2006) 234-242
33. Pandey S., and Agrawal D.K. Immunobiology of Toll-like receptors: emerging trends. Immunol. Cell Biol. 84 (2006) 333-341
34. Parker L.C., Prince L.R., and Sabroe I. Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clin. Exp. Immunol. 147 (2007) 199-207
35. Pasare C., and Medzhitov R. Toll-like receptors: linking innate and adaptive immunity. Microbes Infect. 6 (2004) 1382-1387
36. Pulendran B. Modulating vaccine responses with dendritic cells and Toll-like receptors. Immunol. Rev. 199 (2004) 227-250
37. Roge R., Thorsen J., Torring C., Ozbay A., Moller B.K., and Carstens J. Commonly used reference genes are actively regulated in in vitro stimulated lymphocytes. Scand. J. Immunol. 65 (2007) 202-209
38. Salem M.L., El-Naggar S.A., Kadima A., Gillanders W.E., and Cole D.J. The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu. Vaccine 24 (2006) 5119-5132
39. Singh Suri S., Janardhan K.S., Parbhakar O., Caldwell S., Appleyard G., and Singh B. Expression of toll-like receptor 4 and 2 in horse lungs. Vet. Res. 37 (2006) 541-551
40. Solis M., Romieu-Mourez R., Goubau D., Grandvaux N., Mesplede T., Julkunen I., Nardin A., Salcedo M., and Hiscott J. Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages. Eur. J. Immunol. 37 (2007) 528-539
41. Su X., Li S., Meng M., Qian W., Xie W., Chen D., Zhai Z., and Shu H.B. TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling. Eur. J. Immunol. 36 (2006) 199-206
42. Sun W.C., Moore J.N., Hurley D.J., Vandenplas M.L., Linden J., Cao Z., and Murray T.F. Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-a by equine monocytes. Vet. Immunol. Immunopathol. 121 (2008) 91-100
43. Takeda K., and Akira S. Toll-like receptors in innate immunity. Int. Immunol. 17 (2005) 1-14
44. Takeda K., Kaisho T., and Akira S. Toll-like receptors. Annu. Rev. Immunol. 21 (2003) 335-376
45. Toshchakov V., Jones B.W., Perera P.Y., Thomas K., Cody M.J., Zhang S., Williams B.R., Major J., Hamilton T.A., Fenton M.J., and Vogel S.N. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat. Immunol. 3 (2002) 392-398
46. Tsan M.F., and Baochong G. Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors. J. Endotoxin Res. 13 (2007) 6-14
47. Werling D., and Jungi T.W. TOLL-like receptors linking innate and adaptive immune response. Vet. Immunol. Immunopathol. 91 (2003) 1-12
48. Werners A.H., Bull S., and Fink-Gremmels J. Endotoxaemia: a review with implications for the horse. Equine Vet. J. 37 (2005) 371-383
49. Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., Takeuchi O., Sugiyama M., Okabe M., Takeda K., and Akira S. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301 (2003) 640-643
50. Zhang Y.W., Davis E.G., Blecha F., and Wilkerson M.J. Molecular cloning and characterization of equine Toll-like receptor 9. Vet. Immunol. Immunopathol. 124 (2008) 209-219
51. Zughaier S.M., Zimmer S.M., Datta A., Carlson R.W., and Stephens D.S. Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins. Infect. Immun. 73 (2005) 2940-2950