Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-κb and induces tissue factor and PAI-1 expression: A potential link to accelerated arteriosclerosis

Circulation

Volumn 100, Issue 13, 1999, Pages 1369-1373

  Dechend, Ralf ^a   Maass, M ^b   Gieffers, J ^b   Dietz, R ^c   Scheidereit, C ^a   Leutz, A ^a   Gulba, D C ^c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Arteriosclerosis; C. pneumoniae; Interleukins; Plasminogen activator inhibitor 1; Tissue factor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBOPLASTIN;

ARTERIOSCLEROSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BACTERIAL INFECTION; CHLAMYDOPHILA PNEUMONIAE; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; GENE ACTIVATION; GENE OVEREXPRESSION; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOGENICITY; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

EID: 0033613066     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.100.13.1369     Document Type: Article

References (23)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
2. Burke AP, Färb A, Malcom GT, Liang YH, Smialek J, Virmani R. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997;336:1276-1282.
3. Mlot C. Chlamydia linked to atherosclerosis. Science. 1996;272:1422.
4. Capron L. Chlamydia in coronary plaques - hidden culprit or harmless hobo? Nat Med. 1996;2:856-857.
5. Kol A, Sukhova GK, Lichtman AH, Libby P. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation. 1998;98:300-307.
6. Fuster V, Fallon JT, Nemerson Y. Coronary thrombosis. Lancet. 1996; 348:7-10.
7. Maass M, Bartels C, Engel PM, Mamat U, Sievers HH. Endovascular presence of viable Chlamydia pneumoniae is a common phenomenon in coronary artery disease. J Am Coll Cardiol. 1998;31:827-831.
8. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A. The Bcl-3 oncoprotein acts as a bridging factor between NF-kB/Rel and nuclear co-regulators. Oncogene. 1999; 18:3316-3323.
9. Kowenz Leutz E, Twamley G, Ansieau S, Leutz A. Novel mechanism of C/EBP beta (NF-M) transcriptional control: activation through derepression. Genes Dev. 1994;8:2781-2791.
10. Bartels C, Maass M, Bein G, Malisius R, Brill N, Bechtel JFM, Sayk F, Feller AC, Sievers HH. Detection of Chlamydia pneumoniae but not CMV in occluded saphenous vein coronary-artery bypass grafts. Circulation. 1999;99:879-882.
11. Moll T, Czyz M, Holzmuller H, Hofer Warbinek R, Wagner E, Winkler H, Bach FH, Hofer E. Regulation of the tissue factor promoter in endothelial cells. Binding of NF kappa B-, AP-1-, and Sp1-like transcription factors. J Biol Chem. 1995;270:3849-3857.
12. Muraoka K, Shimizu K, Sun X, Zhang YK, Tani T, Hashimoto T, Yagi M, Miyazaki I, Yamamoto K. Hypoxia, but not reoxygenation, induces interleukin 6 gene expression through NF-kappa B activation. Transplantation. 1997;63:466-470.
13. Dawson SJ, Wiman B, Hamsten A, Green F, Humphries S, Henney AM. The two allele sequences of a common polymorphism in the promoter of the PAI-1 gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem. 1993;268:10739-10745.
14. Ferran C, Millan MT, Csizmadia V, Cooper JT, Brostjan C, Bach FH, Winkler H. Inhibition of NF-kappa B by pyrrolidine dithiocarbamate blocks endothelial cell activation. Biochem Biophys Res Commun. 1995; 214:212-223.
15. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997;336:1066-1071.
16. Shi RJ, Simpson Haidaris PJ, Lerner NB, Marder VJ, Silverman DJ, Sporn LA. Transcriptional regulation of endothelial cell tissue factor expression during Rickettsia rickettsii infection: involvement of the transcription factor NF-kappaB. Infect Immun. 1998;66:1070-1075.
17. Fryer RH, Schwobe EP, Woods ML, Rodgers GM. Chlamydia species infect human vascular endothelial cells and induce procoagulant activity. J Investig Med. 1997;45:168-174.
18. Kukielka GL, Youker KA, Hawkins HK, Perrard JL, Michael LH, Ballantyne CM, Smith CW, Entman ML. Regulation of ICAM-1 and IL-6 in myocardial ischemia: effect of reperfusion. Ann N Y Acad Sci. 1994; 723:258-270.
19. Seino Y, Ikeda U, Ikeda M, Yamamoto K, Misawa Y, Hasegawa T, Kano S, Shimada K. Interleukin 6 gene transcripts are expressed in human atherosclerotic lesions. Cytokine. 1994;6:87-91.
20. Yazdani S, Simon AD, Vidhun R, Gulotta C, Schwartz A, Rabbani LE. Inflammatory profile in unstable angina versus stable angina in patients undergoing percutaneous interventions. Am Heart J. 1998;136:357-361.
21. Hansson GK. Immunological control mechanisms in plaque formation. Basic Res Cardiol. 1994;89(suppl 1):41-46.
22. Brand K, Page S, Rogler G, Bartsch A, Brandl R, Knuechel R, Page M, Kaltschmidt C, Baeuerle PA, Neumeier D. Activated transcription factor NF-κB is present in the atherosclerotic lesion. J Clin Invest. 1996;97: 1715-1722.
23. Clifton DR, Goss RA, Sahni SK, van Antwerp D, Baggs RB, Marder VJ, Silverman DJ, Sporn LA. NF-kappa B-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection. Proc Natl Acad Sci U S A. 1998;95:4646-4651.