Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo

Journal of Biological Chemistry

Volumn 283, Issue 47, 2008, Pages 32506-32515

  Lund, Ida K ^a   Jögi, Annika ^a   Rønø, Birgitte ^a   Rasch, Morten G ^a   Lund, Leif R ^a   Almholt, Kasper ^a   Gårdsvoll, Henrik ^a   Behrendt, Niels ^a   Rømer, John ^a   Høyer Hansen, Gunilla ^a  

^a FINSEN LABORATORY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ASSAYS; CHEMICAL ACTIVATION; ENZYMES; MONOCLONAL ANTIBODIES; SURFACE PLASMON RESONANCE;

CATALYTIC SITES; DEPENDENT PROCESSES; ENZYME KINETIC ANALYSES; IMMUNOSORBENT ASSAYS; IN VITRO; IN VIVO STUDIES; IN-VIVO; MOUSE MODELS; MURINE MONOCLONAL ANTIBODIES; PHYSIOLOGICAL PROCESSES; PLASMINOGEN ACTIVATIONS; PLASMINOGEN ACTIVATORS; PROTEOLYTIC FUNCTIONS; RECOMBINANT PROTEINS; SURFACE PLASMONS; SYSTEMIC ADMINISTRATIONS; WESTERN BLOTTING;

ENZYME ACTIVITY;

ANTHRAX TOXIN; EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MU 3; MONOCLONAL ANTIBODY MU1; MONOCLONAL ANTIBODY MU2; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBRINOLYSIS; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MIMICRY; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PHENOTYPE; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN TARGETING; SURFACE PLASMON RESONANCE; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBRINOLYSIS; KINETICS; LIVER; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PROTEIN BINDING; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

MURINAE; MUS;

EID: 57749119510     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801924200     Document Type: Article

References (40)

1. Danø, K., Behrendt, N., Høyer-Hansen, G., Johnsen, M., Lund, L. R., Ploug, M., and Rømer, J. (2005) Thromb. Haemostasis 93, 676-681
2. Egeblad, M., and Werb, Z. (2002) Nat. Rev. Cancer 2, 161-174
3. Ellis, V., Scully, M. F., and Kakkar, V. V. (1989) J. Biol. Chem. 264, 2185-2188
4. Petersen, L. C., Lund, L. R., Nielsen, L. S., Danø, K., and Skriver, L. (1988) J. Biol. Chem. 263, 11189-11195
5. Ellis, V., Behrendt, N., and Danø, K. (1991) J. Biol. Chem. 266, 12752-12758
6. Andreasen, P. A., Egelund, R., and Petersen, H. H. (2000) CMLS Cell. Mol. Life Sci. 57, 25-40
7. Lund, L. R., Green, K. A., Stoop, A. A., Ploug, M., Almholt, K., Lilla, J., Nielsen, B. S., Christensen, I. J., Craik, C. S., Werb, Z., Danø, K., and Rømer, J. (2006) EMBO J. 25, 2686-2697
8. Bugge, T. H., Flick, M. J., Danton, M. J., Daugherty, C. C., Rømer, J., Danø, K., Carmeliet, P., Collen, D., and Degen, J. L. (1996) Proc. Natl. Acad. Sci. U. S. A 93, 5899-5904
9. Rømer, J., Bugge, T. H., Pyke, C., Lund, L. R., Flick, M. J., Degen, J. L., and Danø, K. (1996) Nat. Med. 2, 287-292
10. Solberg, H., Rinkenberger, J., Danø, K., Werb, Z., and Lund, L. R. (2003) Development 130, 4439-4450
11. Green, K. A., and Lund, L. R. (2005) BioEssays 27, 894-903
12. Collen, D., and Lijnen, H. R. (2005) Thromb. Haemostasis 93, 627-630
13. Carmeliet, P., Schoonjans, L., Kieckens, L., Ream, B., Degen, J., Bronson, R., De Vos, R., van den Oord, J. J., Collen, D., and Mulligan, R. C. (1994) Nature 368, 419-424
14. Bugge, T. H., Suh, T. T., Flick, M. J., Daugherty, C. C., Rømer, J., Solberg, H., Ellis, V., Danø, K., and Degen, J. L. (1995) J. Biol. Chem. 270, 16886-16894
15. Dewerchin, M., Nuffelen, A. V., Wallays, G., Bouche, A., Moons, L., Carmeliet, P., Mulligan, R. C., and Collen, D. (1996) J. Clin. Investig. 97, 870-878
16. Bugge, T. H., Flick, M. J., Daugherty, C. C., and Degen, J. L. (1995) Genes Dev. 9, 794-807
17. Shanmukhappa, K., Sabla, G. E., Degen, J. L., and Bezerra, J. A. (2006)BMC Gastroenterol. 6, 40
18. Carmeliet, P., Moons, L., Dewerchin, M., Rosenberg, S., Herbert, J. M., Lupu, F., and Collen, D. (1998) J. Cell Biol. 140, 233-245
19. Schmitt, M., Harbeck, N., Thomssen, C., Wilhelm, O., Magdolen, V., Reuning, U., Ulm, K., Höfler, H., Jänicke, F., and Graeff, H. (1997) Thromb. Haemostasis 78, 285-296
20. Gårdsvoll, H., Gilquin, B., Le Du, M. H., Ménèz, A., Jørgensen, T. J., and Ploug, M. (2006) J. Biol. Chem. 281, 19260-19272
21. Pass, J., Jögi, A., Lund, I. K., Rønø, B., Rasch, M. G., Gårdsvoll, H., Lund, L. R., Ploug, M., Rømer, J., Danø, K., and Høyer-Hansen, G. (2007) Thromb. Haemostasis 97, 1013-1022
22. Danø, K., Moller, V., Ossowski, L., and Nielsen, L. S. (1980) Biochim. Biophys. Acta 613, 542-555
23. Liu, S., Bugge, T. H., and Leppla, S. H. (2001) J. Biol. Chem. 276, 17976-17984
24. Jögi, A., Pass, J., Høyer-Hansen, G., Lund, L. R., Nielsen, B. S., Danø, K., and Rømer, J. (2007) J. Thromb. Haemostasis 5, 1936-1944
25. de St. Groth, S. F., and Scheidegger, D. (1980) J. Immunol. Methods 35, 1-21
26. Belin, D., Vassalli, J. D., Combepine, C., Godeau, F., Nagamine, Y., Reich, E., Kocher, H. P., and Duvoisin, R. M. (1985) Eur. J. Biochem. 148, 225-232
27. Egelund, R., Petersen, T. E., and Andreasen, P. A. (2001) Eur. J Biochem. 268, 673-685
28. Stoppelli, M. P., Corti, A., Soffientini, A., Cassani, G., Blasi, F., and Assoian, R. K. (1985) Proc. Natl. Acad. Sci. U. S. A 82, 4939-4943
29. Liu, S., Aaronson, H., Mitola, D. J., Leppla, S. H., and Bugge, T. H. (2003) Proc. Natl. Acad. Sci. U. S. A 100, 657-662
30. Almholt, K., Lund, L. R., Rygaard, J., Nielsen, B. S., Danø, K., Rømer, J., and Johnsen, M. (2005) Int. J. Cancer 113, 525-532
31. Declerck, P. J., Carmeliet, P., Verstreken, M., Cock, F. D., and Collen, D. (1995) J. Biol. Chem. 270, 8397-8400
32. Scott, K. A., Moore, R. J., Arnott, C. H., East, N., Thompson, R. G., Scallon, B. J., Shealy, D. J., and Balkwill, F. R. (2003) Mol. Cancer Ther. 2, 445-451
33. Duffy, M. J. (2004) Curr. Pharm. Des. 10, 39-49
34. Harbeck, N., Kates, R. E., Gauger, K., Willems, A., Kiechle, M., Magdolen, V., and Schmitt, M. (2004) Thromb. Haemostasis 91, 450-456
35. Setyono-Han, B., Sturzebecher, J., Schmalix, W. A., Muehlenweg, B., Sieuwerts, A. M., Timmermans, M., Magdolen, V., Schmitt, M., Klijn, J. G., and Foekens, J. A. (2005) Thromb. Haemostasis 93, 779-786
36. Guo, Y., Mazar, A. P., Lebrun, J. J., and Rabbani, S. A. (2002) Cancer Res. 62, 4678-4684
37. Mishima, K., Mazar, A. P., Gown, A., Skelly, M., Ji, X. D., Wang, X. D., Jones, T. R., Cavenee, W. K., and Huang, H. J. (2000) Proc. Natl. Acad. Sci. U. S. A 97, 8484-8489
38. Guo, Y., Higazi, A. A., Arakelian, A., Sachais, B. S., Cines, D., Goldfarb, R. H., Jones, T. R., Kwaan, H., Mazar, A. P., and Rabbani, S. A. (2000) FASEB J. 14, 1400-1410
39. Groner, B., Hartmann, C., and Wels, W. (2004) Curr. Mol. Med. 4, 539-547
40. Behrendt, N., List, K., Andreasen, P. A., and Danø, K. (2003) Biochem. J. 371, 277-287