-
1
-
-
84959808645
-
Fibrinolytic activity of hemolytic streptococci
-
Tillett WS, Garner RL. Fibrinolytic activity of hemolytic streptococci. J Exper Med 1933; 58: 485-502.
-
(1933)
J. Exper. Med.
, vol.58
, pp. 485-502
-
-
Tillett, W.S.1
Garner, R.L.2
-
2
-
-
0001016435
-
Fibrinolysis in animal organism
-
Astrup T, Permin PM. Fibrinolysis in animal organism. Nature 1947; 159: 681-2.
-
(1947)
Nature
, vol.159
, pp. 681-682
-
-
Astrup, T.1
Permin, P.M.2
-
3
-
-
0000737856
-
Staphylokinase: An activator of plasma protease
-
Lack CH. Staphylokinase: an activator of plasma protease. Nature 1948; 161: 559-60.
-
(1948)
Nature
, vol.161
, pp. 559-560
-
-
Lack, C.H.1
-
4
-
-
0001526346
-
Fibrinolytic activity of normal urine
-
Macfarlane RG, Pilling J. Fibrinolytic activity of normal urine. Nature 1947; 159: 779.
-
(1947)
Nature
, vol.159
, pp. 779
-
-
Macfarlane, R.G.1
Pilling, J.2
-
5
-
-
0013273865
-
The fibrinolytic activity of urine
-
Williams JRB. The fibrinolytic activity of urine. Br J Exper Pathol 1951; 32: 530-7.
-
(1951)
Br. J. Exper. Pathol.
, vol.32
, pp. 530-537
-
-
Williams, J.R.B.1
-
6
-
-
0015611848
-
Increased plasminogen activator (urokinase) in tissue culture after fibrin deposition
-
Bernik MB. Increased plasminogen activator (urokinase) in tissue culture after fibrin deposition. J Clin Invest 1973; 52: 823-34.
-
(1973)
J. Clin. Invest.
, vol.52
, pp. 823-834
-
-
Bernik, M.B.1
-
7
-
-
0017362689
-
Plasminogen activator from human embryonic kidney cell cultures. Evidence for a proactivator
-
Nolan C, Hall L, Barlow G, et al. Plasminogen activator from human embryonic kidney cell cultures. Evidence for a proactivator. Biochim Biophys Acta 1977; 496: 384-400.
-
(1977)
Biochim. Biophys. Acta
, vol.496
, pp. 384-400
-
-
Nolan, C.1
Hall, L.2
Barlow, G.3
-
8
-
-
0018893682
-
On the regulation and control of fibrinolysis
-
Collen D. On the regulation and control of fibrinolysis. Thromb Haemost 1980; 43: 77-89.
-
(1980)
Thromb. Haemost.
, vol.43
, pp. 77-89
-
-
Collen, D.1
-
9
-
-
5144220471
-
Tissue-type plasminogen activator: A historical perspective and personal account
-
Collen D, Lijnen HR. Tissue-type plasminogen activator: a historical perspective and personal account. J Thromb Haemost 2004; 2: 541-6.
-
(2004)
J. Thromb. Haemost.
, vol.2
, pp. 541-546
-
-
Collen, D.1
Lijnen, H.R.2
-
10
-
-
0020655457
-
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli
-
Pennica D, Holmes WE, Kohr WJ, et al. Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature 1983; 301: 214-21.
-
(1983)
Nature
, vol.301
, pp. 214-221
-
-
Pennica, D.1
Holmes, W.E.2
Kohr, W.J.3
-
11
-
-
0002631928
-
Tissue-type plasminogen activator
-
Barrett AJ, Rawlings ND, Woessner JF, eds, Academic Press,
-
Lijnen HR, Collen D. Tissue-type plasminogen activator. In: Handbook of proteolytic enzymes, Barrett AJ, Rawlings ND, Woessner JF, eds, Academic Press, 1998; 184-90.
-
(1998)
Handbook of Proteolytic Enzymes
, pp. 184-190
-
-
Lijnen, H.R.1
Collen, D.2
-
12
-
-
0020472522
-
Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin
-
Hoylaerts M, Rijken DC, Lijnen HR, et al. Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. J Biol Chem 1982; 257: 2912-9.
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 2912-2919
-
-
Hoylaerts, M.1
Rijken, D.C.2
Lijnen, H.R.3
-
13
-
-
0027078388
-
The mechanism of plasminogen activation and the variability of the fibrin effector during tissue-type plasminogen activator-mediated fibrinolysis
-
Thorsen S. The mechanism of plasminogen activation and the variability of the fibrin effector during tissue-type plasminogen activator-mediated fibrinolysis. Ann NY Acad Sci 1992; 667: 52-63.
-
(1992)
Ann. NY Acad. Sci.
, vol.667
, pp. 52-63
-
-
Thorsen, S.1
-
14
-
-
0027240597
-
An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction
-
The GUSTO Investigators
-
The GUSTO Investigators. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 1993; 329: 673-82.
-
(1993)
N. Engl. J. Med.
, vol.329
, pp. 673-682
-
-
-
15
-
-
0027424433
-
The effects of tissue plasminogen activator, streptokinase or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction
-
GUSTO Angiographic Investigators
-
GUSTO Angiographic Investigators. The effects of tissue plasminogen activator, streptokinase or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction. N Engl J Med 1993; 329: 1615-22.
-
(1993)
N. Engl. J. Med.
, vol.329
, pp. 1615-1622
-
-
-
16
-
-
0026575312
-
Biochemical properties of the kringle 2 and protease domains are maintained in the refolded t-PA deletion variant BM 06.022
-
Kohnert U, Rudolph R, Verheijen JH, et al. Biochemical properties of the kringle 2 and protease domains are maintained in the refolded t-PA deletion variant BM 06.022. Prot Engineer 1992; 5: 93-100.
-
(1992)
Prot. Engineer.
, vol.5
, pp. 93-100
-
-
Kohnert, U.1
Rudolph, R.2
Verheijen, J.H.3
-
17
-
-
0030879325
-
A comparison of reteplase with alteplase for acute myocardial infarction
-
The GUSTO-III investigators
-
The GUSTO-III investigators. A comparison of reteplase with alteplase for acute myocardial infarction. N Engl J Med 1997; 337: 1118-23.
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 1118-1123
-
-
-
18
-
-
0027223892
-
A slow clearing, fibrin-specific, PAI-1 resistant variant of t-PA (T103N,KHRR296-299AAAA)
-
Paoni NF, Keyt BA, Refino CJ, et al. A slow clearing, fibrin-specific, PAI-1 resistant variant of t-PA (T103N,KHRR296-299AAAA). Thromb Haemost 1993; 70: 307-12.
-
(1993)
Thromb. Haemost.
, vol.70
, pp. 307-312
-
-
Paoni, N.F.1
Keyt, B.A.2
Refino, C.J.3
-
19
-
-
0038446754
-
Safety and efficacy of tenecteplase in acute myocardial infarction
-
Guerra DR, Karha J, Gibson CM. Safety and efficacy of tenecteplase in acute myocardial infarction. Expert Opin Pharmacother 2003; 4: 791-8.
-
(2003)
Expert Opin. Pharmacother.
, vol.4
, pp. 791-798
-
-
Guerra, D.R.1
Karha, J.2
Gibson, C.M.3
-
20
-
-
0032542048
-
Evaluation of a weight-adjusted single-bolus plasminogen activator in patients with myocardial infarction: A double-blind, randomized angiographic trial of lanoteplase versus alteplase
-
Den Heijer P, Vermeer F, Ambrosioni E, et al. Evaluation of a weight-adjusted single-bolus plasminogen activator in patients with myocardial infarction: a double-blind, randomized angiographic trial of lanoteplase versus alteplase. Circulation 1998; 98: 2117-25.
-
(1998)
Circulation
, vol.98
, pp. 2117-2125
-
-
Den Heijer, P.1
Vermeer, F.2
Ambrosioni, E.3
-
21
-
-
0025735319
-
Thrombolytic properties of a novel modified human tissue-type plasminogen activator (E6010): A bolus injection of E6010 has equivalent potency of lysing young and aged canine coronary thrombi
-
Suzuki S, Saito M, Suzuki N, et al. Thrombolytic properties of a novel modified human tissue-type plasminogen activator (E6010): a bolus injection of E6010 has equivalent potency of lysing young and aged canine coronary thrombi. J Cardiovasc Pharmacol 1991; 17: 738-46.
-
(1991)
J. Cardiovasc. Pharmacol.
, vol.17
, pp. 738-746
-
-
Suzuki, S.1
Saito, M.2
Suzuki, N.3
-
22
-
-
0000702955
-
Biochemical and pharmacokinetic properties of YM866, a novel fibrinolytic agent
-
(Abstract 1794)
-
Katoh M, Suzuki Y, Miyamoto T. Biochemical and pharmacokinetic properties of YM866, a novel fibrinolytic agent. Thromb Haemost 1991; 65: 1193 (Abstract 1794).
-
(1991)
Thromb. Haemost.
, vol.65
, pp. 1193
-
-
Katoh, M.1
Suzuki, Y.2
Miyamoto, T.3
-
23
-
-
0026077159
-
The plasminogen activator family from the salivary gland of the vampire bat Desmodus rotundus: Cloning and expression
-
Krätzschmar J, Haendler B, Langer G. The plasminogen activator family from the salivary gland of the vampire bat Desmodus rotundus: cloning and expression. Gene 1991; 105: 229-37.
-
(1991)
Gene
, vol.105
, pp. 229-237
-
-
Krätzschmar, J.1
Haendler, B.2
Langer, G.3
-
24
-
-
0025772644
-
Strategies for the improvement of thrombolytic agents
-
Lijnen HR, Collen D. Strategies for the improvement of thrombolytic agents. Thromb Haemost 1991; 66: 88-110.
-
(1991)
Thromb. Haemost.
, vol.66
, pp. 88-110
-
-
Lijnen, H.R.1
Collen, D.2
-
25
-
-
16844369986
-
New thrombolytic strategies and agents
-
Lijnen HR, Collen D. New thrombolytic strategies and agents. Hematologica 2000; 85 Suppl 2: 106-9.
-
(2000)
Hematologica
, vol.85
, Issue.SUPPL. 2
, pp. 106-109
-
-
Lijnen, H.R.1
Collen, D.2
-
27
-
-
0037417523
-
Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: A quantitative review of 23 randomised trials
-
Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 2003; 361: 13-20.
-
(2003)
Lancet
, vol.361
, pp. 13-20
-
-
Keeley, E.C.1
Boura, J.A.2
Grines, C.L.3
-
28
-
-
0035095180
-
Abciximab and early adjunctive percutaneous coronary intervention are associated with improved ST-segment resolution after thrombolysis. Observations from the TIMI 14 trial
-
de Lemos JA, Gibson CM, Antman EM, et al. Abciximab and early adjunctive percutaneous coronary intervention are associated with improved ST-segment resolution after thrombolysis. Observations from the TIMI 14 trial. Am Heart J 2001; 141: 592-8.
-
(2001)
Am. Heart J.
, vol.141
, pp. 592-598
-
-
de Lemos, J.A.1
Gibson, C.M.2
Antman, E.M.3
-
29
-
-
84966157529
-
Cloning and expression of the gene for pro-urokinase in Escherichia coli
-
Holmes WE, Pennica D, Blaber M, et al. Cloning and expression of the gene for pro-urokinase in Escherichia coli. Biotechnology 1985; 3: 923-9.
-
(1985)
Biotechnology
, vol.3
, pp. 923-929
-
-
Holmes, W.E.1
Pennica, D.2
Blaber, M.3
-
30
-
-
0021260107
-
Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (pro-urokinase). A study in vitro and in two animal species
-
Gurewich V, Pannell R, Louie S, et al. Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (pro-urokinase). A study in vitro and in two animal species. J Clin Invest 1984; 73: 1731-9.
-
(1984)
J. Clin. Invest.
, vol.73
, pp. 1731-1739
-
-
Gurewich, V.1
Pannell, R.2
Louie, S.3
-
31
-
-
0025262153
-
Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740---->Ala) and plasmin-resistant scu-PA (Lys158---->Glu)
-
Lijnen HR, Van Hoef B, Nelles L, et al. Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740---->Ala) and plasmin-resistant scu-PA (Lys158---->Glu). J Biol Chem 1990; 265: 5232-6.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 5232-5236
-
-
Lijnen, H.R.1
Van Hoef, B.2
Nelles, L.3
-
32
-
-
0026776671
-
Fragment E-2 from fibrin substantially enhances pro-urokinase-induced Glu-plasminogen activation. A kinetic study using the plasmin-resistant mutant pro-urokinase Ala-158-rpro-UK
-
Liu JN, Gurewich V. Fragment E-2 from fibrin substantially enhances pro-urokinase-induced Glu-plasminogen activation. A kinetic study using the plasmin-resistant mutant pro-urokinase Ala-158-rpro-UK. Biochemistry 1992; 31: 6311-7.
-
(1992)
Biochemistry
, vol.31
, pp. 6311-6317
-
-
Liu, J.N.1
Gurewich, V.2
-
33
-
-
0027302692
-
Mechanism of the enhanced intrinsic activity of single-chain urokinase-type plasminogen activator during ongoing fibrinolysis
-
Fleury V, Lijnen HR, Anglès-Cano E. Mechanism of the enhanced intrinsic activity of single-chain urokinase-type plasminogen activator during ongoing fibrinolysis. J Biol Chem 1993; 268: 18554-9.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 18554-18559
-
-
Fleury, V.1
Lijnen, H.R.2
Anglès-Cano, E.3
-
34
-
-
0022969427
-
Coronary thrombolysis with recombinant single-chain urokinase-type plasminogen activator (rscu-PA) in patients with acute myocardial infarction
-
Van de Werf F, Vanhaecke J, De Geest H, et al. Coronary thrombolysis with recombinant single-chain urokinase-type plasminogen activator (rscu-PA) in patients with acute myocardial infarction. Circulation 1986; 74: 1066-70.
-
(1986)
Circulation
, vol.74
, pp. 1066-1070
-
-
Van de Werf, F.1
Vanhaecke, J.2
De Geest, H.3
-
35
-
-
84919587044
-
Randomised double-blind trial of recombinant pro-urokinase against streptokinase in acute myocardial infarction
-
PRIMI Trial Study Group
-
PRIMI Trial Study Group. Randomised double-blind trial of recombinant pro-urokinase against streptokinase in acute myocardial infarction. Lancet 1989; 1: 863-8.
-
(1989)
Lancet
, vol.1
, pp. 863-868
-
-
-
36
-
-
0032841636
-
Thrombolysis with saruplase versus streptokinase in acute myocardial infarction: Five-years results of the PRIMI trial
-
Spiecker M, Windeler J, Vermeer F, et al. Thrombolysis with saruplase versus streptokinase in acute myocardial infarction: five-years results of the PRIMI trial. Am Heart J 1999; 138: 518-24.
-
(1999)
Am. Heart J.
, vol.138
, pp. 518-524
-
-
Spiecker, M.1
Windeler, J.2
Vermeer, F.3
-
37
-
-
0030980996
-
Comparison of saruplase and alteplase in acute myocardial infarction The
-
SESAM Study Group. Study in Europe with Saruplase and Alteplase in Myocardial Infarction
-
Bar FW, Meyer J, Vermeer F, et al. Comparison of saruplase and alteplase in acute myocardial infarction. SESAM Study Group. The Study in Europe with Saruplase and Alteplase in Myocardial Infarction. Am J Cardiol 1997; 79: 727-32.
-
(1997)
Am. J. Cardiol.
, vol.79
, pp. 727-732
-
-
Bar, F.W.1
Meyer, J.2
Vermeer, F.3
-
38
-
-
0029164835
-
Thrombolysis with recombinant unglycosylated single-chain urokinase-type plasminogen activator (Saruplase) in acute myocardial infarction: Influence on early patency rate (LIMITS Study)
-
On behalf of the LIMITS Study Group
-
Tebbe U, Windeler J, Boesl I, et al. On behalf of the LIMITS Study Group. Thrombolysis with recombinant unglycosylated single-chain urokinase-type plasminogen activator (Saruplase) in acute myocardial infarction: influence on early patency rate (LIMITS Study). J Am Coll Cardiol 1995; 26: 365-73.
-
(1995)
J. Am. Coll. Cardiol.
, vol.26
, pp. 365-373
-
-
Tebbe, U.1
Windeler, J.2
Boesl, I.3
-
39
-
-
0029095798
-
Sequential combination thrombolytic therapy for acute myocardial infarction: Results of the Pro-Urokinase and t-PA Enhancement of Thrombolysis (PATENT) trial
-
Zarich SW, Kowalchuk GJ, Weaver WD, et al. Sequential combination thrombolytic therapy for acute myocardial infarction: results of the Pro-Urokinase and t-PA Enhancement of Thrombolysis (PATENT) trial. J Am Coll Cardiol 1995; 26: 374-9.
-
(1995)
J. Am. Coll. Cardiol.
, vol.26
, pp. 374-379
-
-
Zarich, S.W.1
Kowalchuk, G.J.2
Weaver, W.D.3
-
40
-
-
0031984356
-
PROACT: A phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke
-
PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism
-
del Zoppo GJ, Higashida RT, Furlan AJ, et al. PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke 1998; 29: 4-11.
-
(1998)
Stroke
, vol.29
, pp. 4-11
-
-
del Zoppo, G.J.1
Higashida, R.T.2
Furlan, A.J.3
-
41
-
-
0036362078
-
The role of recombinant pro-urokinase (r-pro-UK) and inra-arterial thrombolysis in acute ischaemic stroke: The PROACT trials. Prolyse in Acute Cerebral Thromboembolism
-
Furlan AJ, Abou-Chebi A. The role of recombinant pro-urokinase (r-pro-UK) and inra-arterial thrombolysis in acute ischaemic stroke: the PROACT trials. Prolyse in Acute Cerebral Thromboembolism. Curr Med Res Opin 2002; 18 Suppl 2: s44-7.
-
(2002)
Curr. Med. Res. Opin.
, vol.18
, Issue.SUPPL. 2
-
-
Furlan, A.J.1
Abou-Chebi, A.2
-
42
-
-
0030888405
-
Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential
-
Rabijns A, De Bondt HL, De Ranter C. Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential. Nat Struct Biol 1997; 4: 357-60.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 357-360
-
-
Rabijns, A.1
De Bondt, H.L.2
De Ranter, C.3
-
43
-
-
0023489489
-
Cloning and expression in Escherichia coli, Bacillus subtilis and Streptococcus sanguis of a gene for staphylokinase: A bacterial plasminogen activator
-
Behnke D, Gerlach D. Cloning and expression in Escherichia coli, Bacillus subtilis and Streptococcus sanguis of a gene for staphylokinase: a bacterial plasminogen activator. Mol Gen Genet 1987; 210: 52834.
-
(1987)
Mol. Gen. Genet.
, vol.210
, pp. 52834
-
-
Behnke, D.1
Gerlach, D.2
-
44
-
-
0026808532
-
Primary structure and gene structure of staphylokinase
-
Collen D, Zhao ZA, Holvoet P, et al. Primary structure and gene structure of staphylokinase. Fibrinolysis 1992; 6: 22631.
-
(1992)
Fibrinolysis
, vol.6
, pp. 22631
-
-
Collen, D.1
Zhao, Z.A.2
Holvoet, P.3
-
45
-
-
0029956190
-
Staphylokinase, a fibrin-specific bacterial plasminogen activator
-
Lijnen HR, Collen D. Staphylokinase, a fibrin-specific bacterial plasminogen activator. Fibrinolysis 1996; 10: 119-26.
-
(1996)
Fibrinolysis
, vol.10
, pp. 119-126
-
-
Lijnen, H.R.1
Collen, D.2
-
46
-
-
0031941584
-
Staphylokinase: A potent, uniquely fibrin-selective thrombolytic agent
-
Collen D. Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent. Nat Med 1998; 4: 279-84.
-
(1998)
Nat. Med.
, vol.4
, pp. 279-284
-
-
Collen, D.1
-
47
-
-
0032722442
-
The plasminogen (fibrinolytic) system
-
Collen D. The plasminogen (fibrinolytic) system. Thromb Haemost 1999; 82: 259-70.
-
(1999)
Thromb. Haemost.
, vol.82
, pp. 259-270
-
-
Collen, D.1
-
48
-
-
0034663308
-
Recombinant staphylokinase variants with reduced antigenicity due to elimination of B-lymphocyte epitopes
-
Laroche Y, Heymans S, Capaert S, et al. Recombinant staphylokinase variants with reduced antigenicity due to elimination of B-lymphocyte epitopes. Blood 2000; 96: 1425-32.
-
(2000)
Blood
, vol.96
, pp. 1425-1432
-
-
Laroche, Y.1
Heymans, S.2
Capaert, S.3
-
49
-
-
0034633820
-
Polyethylene glycol-derivatized cysteine-substitution variants of recombinant staphylokinase for single-bolus treatment of acute myocardial infarction
-
Collen D, Sinnaeve P, Demarsin E, et al. Polyethylene glycol-derivatized cysteine-substitution variants of recombinant staphylokinase for single-bolus treatment of acute myocardial infarction. Circulation 2000; 102: 1766-72.
-
(2000)
Circulation
, vol.102
, pp. 1766-1772
-
-
Collen, D.1
Sinnaeve, P.2
Demarsin, E.3
-
50
-
-
0034068327
-
Collaborative angiographic patency trial of recombinant staphylokinase (CAPTORS)
-
Armstrong P, Burton J, Palisaitis D, et al. Collaborative angiographic patency trial of recombinant staphylokinase (CAPTORS). Am Heart J 2000; 139: 820-3.
-
(2000)
Am. Heart J.
, vol.139
, pp. 820-823
-
-
Armstrong, P.1
Burton, J.2
Palisaitis, D.3
-
51
-
-
0041330641
-
Collaborative Angiographic Patency Trial of Recombinant Staphylokinase (CAPTORS II)
-
CAPTORS II Investigators
-
Armstrong PW, Burton J, Pakola S, et al, CAPTORS II Investigators. Collaborative Angiographic Patency Trial of Recombinant Staphylokinase (CAPTORS II). Am Heart J 2003; 146: 484-8.
-
(2003)
Am. Heart J.
, vol.146
, pp. 484-488
-
-
Armstrong, P.W.1
Burton, J.2
Pakola, S.3
|