Conformationally constrained opioid ligands: The Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 2, 2009, Pages 433-437

  Ballet, Steven ^a   Feytens, Debby ^a   Wachter, Rien De ^a   Vlaeminck, Magali De ^a   Marczak, Ewa D ^b   Salvadori, Severo ^c   Graaf, Chris de ^d   Rognan, Didier ^d   Negri, Lucia ^e   Lattanzi, Roberta ^e   Lazarus, Lawrence H ^b   Tourwé, Dirk ^a   Balboni, Gianfranco ^f  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF FERRARA   (Italy)

^d CNRS   (France)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Constrained amino acids; Opioid peptidomimetics

Indexed keywords

1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 4 AMINO 1,2,4,5 TETRAHYDRO 2 BENZAZEPIN 3 ONE; 4 AMINO 1,2,4,5 TETRAHYDROINDOLO[2,3 C]AZEPIN 3 ONE; AMINO ACID; DELTA OPIATE RECEPTOR ANTAGONIST; DELTORPHIN; DERMORPHIN; ENDOMORPHIN 1; ENDOMORPHIN 2; MU OPIATE RECEPTOR AGONIST; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; IC 50; ILEUM; IN VITRO STUDY; MOLECULAR DOCKING; MOUSE; NONHUMAN; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

LIGANDS; METHYLATION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; STEREOISOMERISM;

EID: 57749110367     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.051     Document Type: Article

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