Suppressed acute phase response to LPS-induced hepatic injury in Smad3-deficient mice

Molecular Immunology

Volumn 46, Issue 3, 2009, Pages 362-365

  Li, Jia Hui ^a   Lv, Kai Yang ^a   Li, Heng Yu ^a   Xia, Zhao Fan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Acute phase proteins; Acute phase response; mRNA expression; Smad3

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; HAPTOGLOBIN; LIPOPOLYSACCHARIDE; OROSOMUCOID; SMAD3 PROTEIN; TRANSFERRIN;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; KNOCKOUT MOUSE; LIVER INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ACUTE DISEASE; ACUTE-PHASE PROTEINS; ACUTE-PHASE REACTION; ANIMALS; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; LIVER; LIVER DISEASES; MICE; MICE, KNOCKOUT; RNA, MESSENGER; SMAD3 PROTEIN; SURVIVAL ANALYSIS;

ANIMALIA; MUS;

EID: 57749102457     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.10.023     Document Type: Article

References (23)

1. Anthoni M., Fyhrquist-Vanni N., Wolff H., Alenius H., and Lauerma A. Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity. Br. J. Dermatol. (2008 June) (Epub ahead of print)
2. Aristidis M., Serhiy S., and Carl-Henrik H. Smad regulation in TGF-β signal transduction. J. Cell Sci. 114 (2001) 4359-4369
3. Ashcroft G.S., and Roberts A.B. Loss of Smad3 modulates wound healing. Cytokine Growth Factor Rev. 11 (2000) 125-131
4. Blobe G.C., Schiemann W.P., and Lodish H.F. Role of transforming growth factor β in human disease. New Eng. J. Med. 342 (2000) 1350-1358
5. Dagmara P., Magdalena B., and Wanda M.K. The Smad pathway in TGF-β signalling. Cell Mol. Biol. Lett. 5 (2000) 381-396
6. Datto M.B., et al. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol. Cell Biol. 19 (1999) 2495-2504
7. de Caestecker M.P., Piek E., and Roberts A.B. The role of TGF-β signaling in cancer. J. Natl. Cancer Inst. 92 (2000) 1388-1402
8. Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425 6958 (2003) 577-584
9. Feng X.H., and Derynck R. Specificity and versatility in TGF-β signaling through Smads. Annu. Rev. Cell Dev. Biol. 21 (2005) 659-693
10. Flanders K.C. Smad3 as a mediator of the fibrotic response. Int. J. Exp. Pathol. 85 2 (2004) 47-64
11. Gabay C., and Kushner I. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 340 17 (1999) 1376
12. Gomez C.R., Goral J., Ramirez L., Kopf M., and Kovacs E.J. Aberrant acute-phase response in aged interleukin-6 knockout mice. Shock 25 6 (2006) 581-585
13. Hochepied T., Berger F.G., Baumann H., and Libert C. Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine Growth Factor Rev. 14 (2003) 25-34
14. Huntoon K.M., Wang Y., Eppolito C.A., Barbour K.W., Berger F.G., Shrikant P.A., and Baumann H. The acute phase protein haptoglobin regulates host immunity. J. Leukoc. Biol. 84 1 (2008) 170-181
15. Kramer F., Torzewski J., Kamenz J., Veit K., Hombach V., Dedio J., and Ivashchenko Y. Interleukin-1β stimulates acute phase response and C-reactive protein synthesis by inducing an NFκB- and C/EBPβ-dependent autocrine interleukin-6 loop. Mol. Immunol. 45 9 (2008) 2678-2689
16. Massagué J. How cells read TGF-β signals. Nat. Rev. Mol. Cell Biol. 1 (2000) 169-178
17. Massagué J., and Chen Y.-G. Controlling TGF-β signaling. Genes Dev. 14 (2000) 627-644
18. Mortensen R.F. C-reactive protein, inflammation, and innate immunity. Immunol. Res. 24 (2001) 163-176
19. Shi Y., and Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 6 (2003) 685-700
20. ten Dijke P., and Hill C.S. New insights into TGF-beta-Smad signalling. Trends Biochem. Sci. 29 5 (2004) 265-273
21. Venteclef N., Smith J.C., Goodwin B., and Delerive P. Liver receptor homolog 1 is a negative regulator of the hepatic acute-phase response. Mol. Cell Biol. 26 18 (2006) 6799-6807
22. Weinstein M., Yang X., Li C., Xu X., and Deng C. Failure of extraembryonic embrane formation and mesoderm induction in embryos lacking the tumor suppressor Smad2. Proc. Natl Acad. Sci. U.S.A. 95 (1998) 9378-9383
23. Yang X., Letterio J.J., Lechleider R.J., Chen L., Hayman R., Gu H., Roberts A.B., and Deng C. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J. 18 5 (1999) 1280-1291