Isolation and characterization of mAMSA-hypersensitive mutants: Cytotoxicity of Top2 covalent complexes containing DNA single strand breaks

Journal of Biological Chemistry

Volumn 283, Issue 43, 2008, Pages 29239-29250

  Rogojina, Anna T ^a   Nitiss, John L ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; GENES; NUCLEIC ACIDS; ORGANIC ACIDS; PROTEINS; YEAST;

ANTI CANCER AGENTS; BIOCHEMICAL ACTIVITIES; CELL KILLINGS; COVALENT COMPLEXES; DOUBLE STRAND BREAKS; ELEVATED LEVELS; ETOPOSIDE; IN CELLS; IN VITRO; INTERCALATING AGENTS; INTERCALATOR; ISOLATION AND CHARACTERIZATIONS; MUTANT PROTEINS; STRAND BREAKS; TOPOISOMERASE II;

DNA;

CP 115 953; CP 1150 953; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; GLYCINE; INTERCALATING AGENT; LEUCINE; MUTANT PROTEIN; N [4 (9 ACRIDINYLAMINO) 3 METHOXYPHENYL]METHANESULPHONANILIDE; PROLINE; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CELL KILLING; COVALENT BOND; CYTOTOXICITY; DRUG ISOLATION; DRUG SENSITIVITY; GENE EXPRESSION; GENE MUTATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE STRANDED DNA BREAK; YEAST;

ALLELES; AMINO ACIDS; AMSACRINE; DNA; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERCALATING AGENTS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; YEASTS;

EID: 57649233024     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804058200     Document Type: Article

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