Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 1, 2009, Pages 344-350

  Fujii, Shinya ^a   Ohta, Kiminori ^b   Goto, Tokuhito ^b   Kagechika, Hiroyuki ^a   Endo, Yasuyuki ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acidic heterocycle; Androgen receptor; Binding; Carborane

Indexed keywords

1 HYDROXYMETHYL 12 [3 (1,2,4 OXADIAZOLE 5 THION 3 YL)PHENYL] 1,12 DICARBADODECABORANE; 1 HYDROXYMETHYL 12 [4 (1,2,4 OXADIAZOLE 5 THION 3 YL)PHENYL] 1,12 DICARBADODECABORANE; ANDROGEN RECEPTOR; ARGININE; CARBORANE DERIVATIVE; HETEROCYCLIC COMPOUND; HYDROXYFLUTAMIDE; OXADIAZOLE DERIVATIVE; STEROID HORMONE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; HYDROGEN BOND; HYDROPHILICITY; MOUSE; NONHUMAN; PHARMACOPHORE; PROTEIN DOMAIN; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ARGININE; BINDING SITES; BORANES; HETEROCYCLIC COMPOUNDS; HUMANS; HYDROGEN BONDING; RECEPTORS, ANDROGEN; THIONES;

EID: 57649156228     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.060     Document Type: Article

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