Androgens in men - Uses and abuses

New England Journal of Medicine

Volumn 334, Issue 11, 1996, Pages 707-714

  Bagatell, Carrie J ^a,b   Bremner, William J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; DANAZOL; FLUOXYMESTERONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; METHYLTESTOSTERONE; NANDROLONE; STANOZOLOL; TESTOSTERONE 4 BUTYLCYCLOHEXANECARBOXYLATE; TESTOSTERONE CIPIONATE; TESTOSTERONE DERIVATIVE; TESTOSTERONE ENANTATE; TESTOSTERONE ESTER; TESTOSTERONE PROPIONATE; TESTOSTERONE UNDECANOATE;

ACNE; ADULT; ANDROGEN THERAPY; ANGIONEUROTIC EDEMA; BONE DENSITY; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTRACEPTION; DRUG ABUSE; DRUG DELIVERY SYSTEM; ENDOMETRIOSIS; ERYTHROCYTOSIS; ERYTHROPOIESIS; GYNECOMASTIA; HEMATOLOGIC DISEASE; HORMONE ACTION; HUMAN; HYPOGONADISM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; INTRAMUSCULAR DRUG ADMINISTRATION; LIVER CYST; MALE; MUSCLE MASS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REPRODUCTION; REVIEW; SEXUAL BEHAVIOR; SLEEP APNEA SYNDROME; TRANSDERMAL DRUG ADMINISTRATION; TREATMENT INDICATION; WEIGHT GAIN;

ADOLESCENT; ADULT; ANDROGENS; ENDOMETRIOSIS; FEMALE; HEMATOLOGIC DISEASES; HUMANS; HYPOGONADISM; MALE; PUBERTY, DELAYED; SUBSTANCE-RELATED DISORDERS;

EID: 0029875771     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199603143341107     Document Type: Review

References (91)

1. Schally AV, Arimura A, Kastin AJ, et al. Gonadotropin-releasing hormone-one polypeptide regulates secretion of lutemizing and follicle-stimulating hormones. Science 1971;173:1036-8.
2. Matsumoto AM. The testis. In: Wyngaarden JB, Smith LH, Bennett JC, eds, Cecil textbook of medicine. 20th ed. Philadelphia: WB. Saunders (in press).
3. Sharpe RM. Regulation of spermatogenesis. In: Knobil E, Neill JD, eds. The physiology of reproduction. 2nd ed. Vol. 1. New York: Raven Press, 1994:1363-434.
4. Luke MC, Coffey DS. The male sex accessory tissues: structure, androgen action, and physiology. In: Knobil E, Neill JD, eds. The physiology of reproduction. 2nd ed. Vol. 1. New York: Raven Press, 1994:1435-87.
5. Jenkins EP, Andersson S, Imperato-McGinley J, Wilson JD, Russell DW. Genetic and pharmacological evidence for more than one human steroid 5α reductase. J Clin Invest 1992,89:293-300.
6. Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocr Rev 1987,8:1-28.
7. Dunn JF, Nisula BC, Rodbard D Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and cortico-steroid-binding globulin in human plasma. J Clin Endocrinol Metab 1981,53:58-68
8. Manni A, Pardridge WM, Cefalu W, et al. Bioavailability of albumin-bound testosterone. J Clin Endocrinol Metab 1985;61:705-10
9. Root A, Steinberger E, Smith K, et al Isosexual pseudoprecocity in a 6-year-old boy with a testicular interstitial cell adenoma. J Pediatr 1972;80.264-8.
10. Santulli R, Sprando RL, Awoniyi CA, Ewing LL, Zirkin BR. To what extent can spermatogenesis be maintained in the hypophysectomized adult rat testis with exogenously administered testosterone? Endocrinology 1990;126:95-101.
11. Davidson JM, Kwan M, Greenleaf WJ. Hormonal replacement and sexuality in men. Clin Endocrinol Metab 1982;11:599-623
12. Bagatell CJ, Heiman JR, Rivier JE, Bremner WJ. Effects of endogenous testosterone and estradiol on sexual behavior in normal young men. J Clin Endocrinol Metab 1994;78:711-6
13. Davidson JM, Camargo CA, Smith ER. Effects of androgen on sexual behavior in hypogonadal men. J Clin Endocrinol Metab 1979;48 955-8.
14. Skakkebaek NE, Bancroft J, Davidson DW, Warner P. Androgen replacement with oral testosterone undecanoate in hypogonadal men: a double blind controlled study. Clin Endocrinol (Oxf) 1981;14:49-61.
15. Kwan M, Greenleaf WJ, Mann J, Crapo L, Davidson JM. The nature of androgen action on male sexuality: a combined laboratory-self-report study on hypogonadal men. J Clin Endocrinol Metab 1983;57.557-62.
16. O'Carroll R, Shapiro C, Bancroft J Androgens, behaviour and nocturnal erection in hypogonadal men: the effects of varying the replacement dose. Clin Endocrinol (Oxf) 1985;23:527-38.
17. Hubert W. Psychotropic effects of testosterone. In: Nieschlag EB, Behre HM, eds Testosterone: action, deficiency, substitution. Berlin, Germany: Springer-Verlag, 1990:51-71.
18. Gooren LJ. Androgen levels and sex functions in testosterone-treated hypogonadal men. Arch Sex Behav 1987,16:463-73.
19. Salmimies P, Kockott G, Pirke KM, Vogt HJ, Schul WB. Effects of testosterone replacement on sexual behavior in hypogonadal men. Arch Sex Behav 1982,11:345-53.
20. Michael RP, Zumpe D. Annual cycles of aggression and plasma testosterone in captive male rhesus monkeys. Psychoneuroendocrinology 1978;3:217-20.
21. Su T-P, Pagliaro M, Schmidt PJ, Pickar D, Wolkowitz O, Rubinow DR. Neuropsychiatric effects of anabolic steroids in male normal volunteers. JAMA 1993;269:2760-4.
22. Bagatell CJ, Heiman JR, Matsumoto AM, Rivier JE, Bremner WJ. Metabolic and behavioral effects of high dose, exogenous testosterone in healthy men J Clin Endocrinol Metab 1994,79:561-7.
23. Anderson RA, Bancroft J, Wu FC The effects of exogenous testosterone on sexuality and mood of normal men. J Clin Endocrinol Metab 1992;75.1503-7.
24. Wilson JD, Griffin JE The use and misuse of androgens. Metabolism 1980, 29:1278-95.
25. Young NR, Baker HWG, Liu G, Seeman E. Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception. J Clin Endocrinol Metab 1993;77:1028-32.
26. Forbes GB. The effect of anabolic steroids on lean body mass: the dose response curve Metabolism 1985;34 571-3.
27. Dickinson P, Zinneman HH, Swaim WR, Doe RP, Seal US. Effects of testosterone treatment on plasma proteins and amino acids in men. J Clin Endocrinol Metab 1969;29:837-41.
28. Heiss G, Tamir I, Davis CE, et al. Lipoprotein-cholesterol distributions in selected North American populations: the Lipid Research Clinics Program Prevalence Study. Circulation 1980,61:302-15.
29. Kirkland RT, Keenan BS, Probstfield IL, et al. Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence: correlation with plasma testosterone levels JAMA 1987;257:502-7.
30. Sorva R, Kuusi T, Taskmen M-R, Perheentupa J, Nikkila EA. Testosterone substitution increases the activity of lipoprotein lipase and hepatic lipase in hypogonadal males. Atherosclerosis 1988;69:191-7.
31. Zmuda JM, Fahrenbach MC, Younkin BT, et al. The effect of testosterone aromatizanon on high-density lipoprotein cholesterol level and postheparin lipolytic activity. Metabolism 1993;42:446-50.
32. Thompson PD, Cullinane EM, Sady SP, et al. Contrasting effects of testosterone and stanozolol on serum lipoprotein levels. JAMA 1989;261:1165-8.
33. Friedl KE, Hannan CJ Jr, Jones RE, Plymate SR. High-density lipoprotein is not decreased if an aromatizable androgen is administered. Metabolism 1990,39:69-74.
34. Alen M, Rahkila P, Marniemi J. Serum lipids in power athletes self-administering testosterone and anabolic steroids. Int J Sports Med 1985;6:139-44.
35. 2-cholesterol and increase hepatic triglyceride lipase activity. Med Sci Sports Excrc 1985;17:462-5
36. Gilsanz V, Gibbens DT, Roe TF, et al. Vertebral bone density in children: effect of puberty. Radiology 1988;166:847-50.
37. Hinkelstein JS, Klibanski A. Effects of androgens on bone metabolism. In: Nieschlag EB, Behre HM, eds Testosterone: action, deficiency, substitution. Berlin, Germany: Springer-Verlag, 1990 204-18.
38. Jackson JA, Kleerekoper M. Osteoporosis in men: diagnosis, pathophysiology, and prevention. Medicine (Baltimore) 1990;69:137-52.
39. Finkelstein JS, Klibanski A, Neer RM, Greenspan SL, Rosenthal DI, Crowley WE Jr. Osteoporosis in men with idiopathic hypogonadotropic hypogonadism. Ann Intern Med 1987;106:354-61.
40. Kasperk CH, Wergedal JE, Farley JR, Linkhart TA, Turner RT, Baylink DJ. Androgens directly stimulate proliferation of bone cells in vitro. Endocrinology 1989;124:1576-8.
41. Kasperk C, Fitzsimmons R, Strong D, et al Studies of the mechanism by which androgens enhance mitogenesis and differentiation in bone cells. J Clin Endocrinol Metab 1990;71:1322-9.
42. Gardner FH, Nathan DG, Piomelli S, Cummins JF. The erythrocythaemic effects of androgens. Br J Haematol 1968,14:611-5.
43. Ammus SS The role of androgens in the treatment of hematologic disorders Adv Intern Med 1989;34 191-208
44. Bagatell CJ, Matsumoto AM, Christensen RB, Rivier JE, Bremner WJ. Comparison of a gonadotropin releasing-hormone antagonist plus testosterone (T) versus T alone as potential male contraceptive regimens. J Clin Endocrinol Metab 1993;77:427-32.
45. Patanelli DJ, ed. Proceedings: hormonal control of male fertility. Washington, D.C., Government Printing Office, 1977. (DHEW publication no. (NIH) 78-1097)
46. Weber JP, Walsh PC, Peters CA, Spivak JL. Effect of reversible androgen deprivation on hemoglobin and serum immunoreactive erythropoietin in men. Am J Hematol 1991;36:190-4.
47. Grossman CJ, Roselle GA, Mendenhall CL. Sex steroid regulation of autoimmumty. J Steroid Biochem Mol Biol 1991,40.649-59.
48. Bizzarro A, Valentini G, Di Martino G, DaPonte A, De Bellis A, Iacono G Influence of testosterone therapy on clinical and immunological features of autoimmune diseases associated with Klinefelter's syndrome. J Clin Endocrinol Metab 1987;64:32-6.
49. Wu FC. Testicular steroidogenesis and androgen use and abuse. Baillieres Clin Endocrinol Metab 1992;6:373-403.
50. Bhasin S. Androgen treatment of hypogonadal men. J Clin Endocnnol Metab 1992;74:1221-5.
51. Meikle AW, Mazer NA, Moellmer JF, et al Enhanced transdermal delivery of testosterone across nonscrotal skin produces physiological concentrations of testosterone and its metabolites in hypogonadal men J Clin Endocrinol Metab 1992;74:623-8.
52. Handelsman DJ, Conway AJ, Boylan LM. Pharmacokinetics and pharmacodynamics of testosterone pellets in man J Clin Endocrinol Metab 1990;71:216-22
53. Behre HM, Nieschlag E Testosterone buciclate (20 Aet-1) in hypogonadal men: pharmacokinetics and pharmacodynamics of the new long-acting androgen ester. J Clin Endocrinol Metab 1992;75:1204-10.
54. Bhasin S, Swerdloff RS, Steiner BS, et al. A biodegradable testosterone microcapsule furmillation provides uniform eugonadal levels of testosterone for 10-11 weeks in hypogonadal men. J Clin Endocnnol Metab 1992,74:75-83.
55. Snyder PJ. Clinical use of androgens. Annu Rev Med 1984;35:207-17.
56. Behre HM, Bohmeyer J, Nieschlag E Prostate volume in testosterone-treated and untreated hypogonadal men in comparison to age-matched normal controls Clin Endocrinol (Oxf) 1994;40 341-9.
57. Joss EE, Mullis PE. Delayed puberty in boys. In: Bardin CW, ed. Current therapy in endocrinology and metabolism 5th ed St. Louis: Mosby-Year Book, 1994:299-300.
58. Gelfand JA, Sherins RJ,Alling DW, Frank MM. Treatment of hereditary angioedema with danazol: reversal of clinical and biochemical abnormalities. N Engl J Med 1976;295:1444-8.
59. Barbieri RL, Ryan KJ. Danazol: endocrine pharmacology and therapeutic applications. Am J Obstet Gynecol 1981,141:453-63.
60. Henzl MR, Corson SL, Moghissi K, Buttram VC, Berqvist C, Jacobson J Administration of nasal nafarelin as compared with oral danazol for endometriosis: a multicenter double-blind comparative clinical trial N Engl J Med 1988;318:485-9.
61. Lemay A, Brideau NA, Forest J-C, Dodin S, Maheux R. Cholesterol fractions and apolipoproteins during endometriosis treatment by a gonadotrophin releasing hormone (GnRH) agonist implant or by danazol. Clin Endocrinol (Oxf) 1991;35:305-10.
62. Bremner WJ, Vitiello MV, Prinz PN Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983;56:1278-81.
63. Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men. results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991;73 1016-25.
64. Tenover JS. Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992;75:1092-8.
65. Motley JE, Perry HM III, Kaiser FE, et al. Effects of testosterone replacement therapy m old hypogonadal males: a preliminary study. J Am Geriatr Soc 1993;41:149-52.
66. World Health Organization Task Force on Methods for the Regulation of Male Fertility Contraceptive efficacy of testosterone-induced azoospermia in normal men. Lancet 1990;336:955-9.
67. Pavlou SN, Brewer K, Parley MG, et al. Combined administration of a gonadotropin-releasing hormone antagonist and testosterone in men induces reversible azoospermia without loss of libido. J Clin Endocrinol Metab 1991;73:1360-9.
68. Tom L, Bhasin S, Salameh W, et al. Induction of azoospermia in normal men with combined Nal-Glu gonadotropin-releasing hormone antagonist and testosterone enanthate. J Clin Endocrinol Metab 1992;75:476-83.
69. Paulsen CA, Bremner WJ, Leonard JM. Male contraception, clinical trials. In. Mishell DR Jr, ed. Advances in fertility research. Vol. 1, New York: Raven Press, 1982:157-70.
70. Bebb RA, Anawalt BA, Christensen RB, Paulsen CA, Bremner WJ, Matsumoto AM. Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach. J Clin Endocrinol Metab 1996;81:757-62.
71. Strauss RH, Yesalis CE. Anabolic steroids in the athlete. Annu Rev Med 1991;42:449-57.
72. Yesalis CE, Kennedy NK, Kopstein AN, Bahrke MS. Anabolic-androgenic steroid use in the United States. JAMA 1993;270:1217-21.
73. Buckley WE, Yesalis CE III, Friedl KE, Anderson WA, Streit AL, Wright JE. Estimated prevalence of anabolic steroid use among male high school seniors JAMA 1988;260 3441-5.
74. Wilson JD. Androgen abuse by athletes. Endocr Rev 1988;9:181-99.
75. Alen M, Rahkila P, Reinila M, Vihko R. Androgenic-anabolic steroid effects on serum thyroid, pituitary and steroid hormones in athletes. Am J Sports Med 1987;15:357-61.
76. Alen M, Reinila M, Vihko R. Response of serum hormones to androgen administration in power athletes. Med Sci Sports Exerc 1985;17:354-9.
77. Wheeler MJ Methods for the detection of testosterone abuse in athletes. Clin Endocrinol (Oxf) 1993;38:351-2.
78. Elashoff JD, Jacknow AD, Shain SG, Braunstein GD. Effects of anabolic-androgenic steroids on muscular strength. Ann Intern Med 1991;115:387-93
79. American College of Sports Medicine position stand on the use of anabolic-androgenic steroids in sports. Med Sci Sports Exerc 1987;19:534-9.
80. Matsumoto AM, Sandblom RE, Schoene RB, et al. Testosterone replacement in hypogonadal men: effects on obstructive sleep apnoea, respiratory drives, and sleep. Clin Endocrinol (Oxf) 1985;22:713-21
81. Ishak KG, Zimmerman HJ. Hepatotoxic effects of the anabolic/androgenic steroids. Semin Liver Dis 1987;7:230-6
82. Gurakar A, Caraceni P, Fagiuoli S, Van Thiel DH. Androgenic/anabolic steroid-induced intrahepatic cholestasis: a review with four additional case reports. J Okla State Med Assoc 1994;87:399-404.
83. Soe KL, Soe M, Gluud C. Liver pathology associated with the use of anabolic-androgenic steroids. Liver 1992;12:73-9.
84. Jacobs DK Jr, Mebane IL, Bangdiwala SI, Criqui MH, Tyroler HA. High density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women the follow-up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol 1990;131:32-47.
85. McNutt RA, Ferenchick GS, Kirlin PC, Hamlin NJ. Acute myocardial infarction in a 22-year-old world class weight lifter using anabolic steroids Am J Cardiol 1988;62:164
86. Frankle MA, Eichberg R, Zachariah SB. Anabolic androgenic steroids and a stroke in an athlete case report. Arch Phys Med Rehabil 1988;69:632-3
87. Ferenchick G, Schwartz D, Ball M, Schwartz K. Androgenic-anabolic steroid abuse and platelet aggregation: a pilot study in weight lifters. Am J Med Sci 1992;303:78-82.
88. Uzych L. Anabolic-androgenic steroids and psychiatric-related effects: a review. Can J Psychiatry 1992;37:23-8.
89. Pope HG Jr, Katz DL. Affective and psychotic symptoms associated with anabolic steroid use. Am J Psychiatry 1988;145:487-90.
90. Bahrke MS, Yesalis CE UI, Wright JE. Psychological and behavioural effects of endogenous testosterone levels and anabolic-androgenic steroids among males: a review. Sports Med 1990;10:303-37
91. Brower KJ, Blow FC, Beresford TP, Fuelling C. Anabolic-androgenic steroid dependence. J Clin Psychiatry 1989;50:31-3.