MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3′-untranslated region of the gene that decrease steady-state levels of the transcript

Journal of Biological Chemistry

Volumn 283, Issue 42, 2008, Pages 28274-28286

  Zhou, Lingyin ^a   Qi, Xiaoping ^a   Potashkin, Judith A ^c   Abdul Karim, Fadi W ^b   Gorodeski, George I ^a,d  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^d UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELL GROWTH; CYTOLOGY; ENZYME ACTIVITY; GROWTH KINETICS; TARGETS;

293 CELLS; APOPTOSIS; CANCER CELLS; EPITHELIAL CELLS; HUMAN EMBRYONIC KIDNEYS; LUCIFERASE ACTIVITIES; LUCIFERASE REPORTERS; MICRO RNAS; MRNA STABILITIES; OVEREXPRESSION; REPORTER GENES; TARGET SITES; UNTRANSLATED REGIONS;

CELLS;

MICRORNA; MICRORNA 150 PROTEIN; MICRORNA 186 PROTEIN; PURINERGIC P2X RECEPTOR; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; CELL ACTIVATION; DOWN REGULATION; EPITHELIUM CELL; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE;

3' UNTRANSLATED REGIONS; APOPTOSIS; BASE SEQUENCE; BINDING SITES; CERVIX UTERI; DACTINOMYCIN; DOWN-REGULATION; ENDOMETRIUM; FEMALE; HELA CELLS; HUMANS; MICRORNAS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; RECEPTORS, PURINERGIC P2;

EID: 57649129015     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802663200     Document Type: Article

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