CD8+ suppressor and cytotoxic T cells recognize the same human leukocyte antigen-A2 restricted cytomegalovirus peptide

Human Immunology

Volumn 69, Issue 11, 2008, Pages 776-780

  Qin, Haiyan ^a   Vlad, George ^a   Cortesini, Raffaello ^a   Suciu Foca, Nicole ^a   Manavalan, John S ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

CTL; Dendritic cells; Peptide epitope; T suppressor cells

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65; EPITOPE; HLA A2 ANTIGEN;

ARTICLE; CD8+ T LYMPHOCYTE; CELL ACTIVITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DENDRITIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SUPPRESSOR CELL;

CELLS, CULTURED; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS VACCINES; DENDRITIC CELLS; EPITOPES, T-LYMPHOCYTE; HLA-A ANTIGENS; HUMANS; MEMBRANE GLYCOPROTEINS; PEPTIDES; PHOSPHOPROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES, CYTOTOXIC; VIRAL MATRIX PROTEINS;

EID: 57649084981     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.08.287     Document Type: Article

References (33)

1. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151-1164
2. Shevach E.M. Certified professionals: CD4(+)CD25(+) suppressor T cells. J Exp Med 193 (2001) F41-F46
3. Hara M., Kingsley C.I., Niimi M., et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 166 (2001) 3789-3796
4. Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., and Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 193 (2001) 1285-1294
5. Lin C.Y., Graca L., Cobbold S.P., and Waldmann H. Dominant transplantation tolerance impairs CD8+ T cell function but not expansion. Nat Immunol 3 (2002) 1208-1213
6. Itoh M., Takahashi T., Sakaguchi N., et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 162 (1999) 5317-5326
7. Shimizu J., Yamazaki S., Takahashi T., Ishida Y., and Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 3 (2002) 135-142
8. Wood K.J., and Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 3 (2003) 199-210
9. Groux H., O'Garra A., Bigler M., et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389 (1997) 737-742
10. Bacchetta R., Bigler M., Touraine J.L., et al. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med 179 (1994) 493-502
11. Liu Z., Tugulea S., Cortesini R., and Suciu-Foca N. Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+CD28- T cells. Int Immunol 10 (1998) 775-783
12. Ciubotariu R., Colovai A.I., Pennesi G., et al. Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8+CD28- regulatory T cells. J Immunol 161 (1998) 5193-5202
13. Jiang S., Tugulea S., Pennesi G., et al. Induction of MHC-class I restricted human suppressor T cells by peptide priming in vitro. Hum Immunol 59 (1998) 690-699
14. Suciu-Foca N., Manavalan J.S., and Cortesini R. Generation and function of antigen specific suppressor and regulatory T cells. Transplant Immunology 11 (2003) 235-244
15. Vlad G., Piazza F., Colovai A., et al. Interleukin-10 induces the upregulation of the inhibitory receptor ILT4 in monocytes from HIV positive individuals. Hum Immunol 64 (2003) 483-489
16. Lederman S., and Suciu-Foca N. Antigen presenting cells integrate opposing signals from CD4+ and CD8+ regulatory T lymphocytes to arbitrate the outcomes of immune responses. Hum Immunol 60 (1999) 533-561
17. Lanzavecchia A. Immunology. Licence to kill. Nature 393 (1998) 413-414
18. Steinbrink K., Wolfl M., Jonuleit H., Knop J., and Enk A.H. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159 (1997) 4772-4780
19. Steinbrink K., Jonuleit H., Muller G., Schuler G., Knop J., and Enk A.H. Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells. Blood 93 (1999) 1634-1642
20. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., and Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 193 (2001) 233-238
21. Kuwana M., Kaburaki J., Wright T.M., Kawakami Y., and Ikeda Y. Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors. Eur J Immunol 31 (2001) 2547-2557
22. Roncarolo M.G., Levings M.K., and Traversari C. Differentiation of T regulatory cells by immature dendritic cells. J Exp Med 193 (2001) F5-F9
23. Suciu-Foca Cortesini N., Piazza F., et al. Distinct mRNA microarray profiles of tolerogenic dendritic cells. Hum Immunol 62 (2001) 1065-1072
24. Chang C.C., Ciubotariu R., et al. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 3 (2002) 237-243
25. Gilliet M., and Liu Y.J. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med 195 (2002) 695-704
26. Manavalan J.S., Rossi P., Vlad G., Piazza F., Yarilina A., Cortesini R., et al. High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol 11 (2003) 245-258
27. Adorini L., Barnaba V., Bona C., et al. New perspectives on immunointervention in autoimmune diseases. Immunol Today 11 (1990) 383-386
28. Elkington R., Walker S., Crough T., et al. Ex vivo profiling of CD8+-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers. J Virol 77 (2003) 5226-5240
29. Salter R.D., and Cresswell P. Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid. EMBO J 5 (1986) 943-949
30. Liu Z., Colovai A.I., Tugulea S., Reed E.F., Fisher P.E., Mancini D., et al. Indirect recognition of donor HLA-DR peptides in organ allograft rejection. J Clin Invest 98 (1996) 1150-1157
31. Ciubotariu R., Liu Z., Colovai A.I., Ho E., Itescu S., Ravalli S., et al. Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts. J Clin Invest 101 (1998) 398-405
32. Suciu-Foca N., Feirt N., Zhang Q.Y., Vlad G., Liu Z., Lin H., Chang C.C., Ho E.K., Colovai A.I., Kaufman H., D'Agati V.D., Thaker H.M., Remotti H., Galluzzo S., Cinti P., Rabitti C., Allendorf A., Chabot J., Caricato M., Coppola R., Berloco P., and Cortesini R. Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized-SCID mice and T cell responses in cancer patients. J Immunol 178 (2007) 7432-7441
33. Vlad G., D'Agati V.D., Zhang Q.Y., Liu Z., Ho E.K., Mohanakumar T., Hardy M.A., Cortesini R., and Suciu-Foca N. Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice. Diabetes 57 (2008) 1878-1886