Antigen presenting cells integrate opposing signals from CD4+ and CD8+ regulatory T lymphocytes to arbitrate the outcomes of immune responses

Human Immunology

Volumn 60, Issue 7, 1999, Pages 553-561

  Lederman, Seth ^a,b   Suciu Foca, Nicole ^c  

^a Laboratory of Molecular Immunology   (United States)

^b Departments of Preventive Medicine   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Antigen processing cells; Helper function; Immune regulation; MHC; Suppressor function

Indexed keywords

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; CELL INTERACTION; CELL SELECTION; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; HUMAN; IMMUNOLOGY;

ANIMALS; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; SIGNAL TRANSDUCTION;

EID: 0033158234     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(99)00045-2     Document Type: Review

References (95)

1. Cantor H., Boyse E.A. Functional subclasses of T-lymphocytes bearing different Ly antigens I The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen . J Exp Med. 141:1975;1376.
2. Kung P., Goldstein G., Reinherz E.L., Schlossman S.F. Monoclonal antibodies defining distinctive human T cell surface antigens. Science. 206:1979;347.
3. Kung P.C., Goldstein G. Functional and developmental compartments of human T lymphocytes. Vox Sang. 39:1980;121.
4. Reinherz E.L., Schlossman S.F. Regulation of the immune response - inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med. 303:1980;370.
5. Krensky A.M., Reiss C.S., Mier J.W., Strominger J.L., Burakoff S.J. Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+. Proc Natl Acad Sci USA. 79:1982;2365.
6. Meuer S.C., Schlossman S.F., Reinherz E.L. Clonal analysis of human cytotoxic T lymphocytes T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions . Proc Natl Acad Sci USA. 79:1982;4395.
7. Biddison W.E., Rao P.E., Talle M.A., Goldstein G., Shaw S. Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens Evidence from studies of cytotoxic T lymphocytes specific for SB antigens . J Exp Med. 156:1982;1065.
8. Chesnut R.W., Grey H.M. Studies on the capacity of B cells to serve as antigen-presenting cells. J Immunol. 126:1981;1075.
9. Ziegler K., Unanue E.R. Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes. J Immunol. 127:1981;1869.
10. Townsend A.R., Bastin J., Gould K., Brownlee G.G. Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence. Nature. 324:1986;575.
11. Liu Z., Colovai A.I., Tugulea S., Reed E.F., Fisher P.E., Mancini D., Rose E.A., Cortesini R., Michler R.E., Suciu-Foca N. Indirect recognition of donor HLA-DR peptides in organ allograft rejection. J Clin Invest. 98:1996;1150.
12. Ciubotariu R., Liu Z., Colovai A.I., Ho E., Itescu S., Ravalli S., Hardy M.A., Cortesini R., Rose E.A., Suciu-Foca N. Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts. J Clin Invest. 101:1998;398.
13. Inaba K., Turley S., Yamaide F., Iyoda T., Mahnke K., Inaba M., Pack M., Subklewe M., Sauter B., Sheff D., Albert M., Bhardwaj N., Mellman I., Steinman R.M. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J Exp Med. 188:1998;2163.
14. Albert M.L., Pearce S.F., Francisco L.M., Sauter B., Roy P., Silverstein R.L., Bhardwaj N. Immature dendritic cells phagocytose apoptotic cells via avb5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med. 188:1998;1359.
15. Albert M.L., Sauter B., Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I- restricted CTLs. Nature. 392:1998;86.
16. Norment A.M., Salter R.D., Parham P., Engelhard V.H., Littman D.R. Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature. 336:1988;79.
17. Doyle C., Strominger J.L. Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature. 330:1987;256.
18. Leahy D.J., Axel R., Hendrickson W.A. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2 6 A resolution. Cell. 68:1992;1145.
19. Garcia K.C., Scott C.A., Brunmark A., Carbone F.R., Peterson P.A., Wilson I.A., Teyton L. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature. 384:1996;577.
20. Kern P.S., Teng M.K., Smolyar A., Liu J.H., Liu J., Hussey R.E., Spoerl R., Chang H.C., Reinherz E.L., Wang J.H. Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8aa ectodomain fragment in complex with H-2Kb. Immunity. 9:1998;519.
21. Wu H., Kwong P.D., Hendrickson W.A. Dimeric association and segmental variability in the structure of human CD4. Nature. 387:1997;527.
22. Garcia K.C., Degano M., Pease L.R., Huang M., Peterson P.A., Teyton L., Wilson I.A. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science. 279:1998;1166.
23. Ding Y.H., Smith K.J., Garboczi D.N., Utz U., Biddison W.E., Wiley D.C. Two human T cell receptors bind in a similar diagonal mode to the HLA- A2/Tax peptide complex using different TCR amino acids. Immunity. 8:1998;403.
24. Cantor H., Boyse E.A. Functional subclasses of T lymphocytes bearing different Ly antigens II Cooperation between subclasses of Ly+ cells in the generation of killer activity . J Exp Med. 141:1975;1390.
25. Cantor H., Shen F.W., Boyse E.A. Separation of helper T cells from suppressor T cells expressing different Ly components II Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses . J Exp Med. 143:1976;1391.
26. Huber B., Devinsky O., Gershon R.K., Cantor H. Cell-mediated immunity delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses . J Exp Med. 143:1976;1534.
27. Cronin DC2 , Stack R, Fitch FW: IL-4-producing CD8+ T cell clones can provide B cell help. J Immunol 154:3118, 1995.
28. Li S.G., Ottenhoff T.H., Van den Elsen P., Koning F., Zhang L., Mak T., De Vries R.R. Human suppressor T cell clones lack CD28. Eur J Immunol. 20:1990;1281.
29. Schoenberger S.P., Toes R.E., d van V., Offringa R., Melief C.J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature. 393:1998;480.
30. Bennett S.R., Carbone F.R., Karamalis F., Flavell R.A., Miller J.F., Heath W.R. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 393:1998;478.
31. Ridge J.P., Di Rosa F., Matzinger P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature. 393:1998;474.
32. Ranheim E.A., Kipps T.J. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med. 177:1993;925.
33. Yellin M.J., Sinning J., Covey L.R., Sherman W., Lee J.J., Glickman-Nir E., Sippel K.C., Rogers J., Cleary A.M., Parker M., Chess L., Lederman S. T lymphocyte T cell-B cell Activating Molecule/CD40-L Molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity. J Immunol. 153:1994;666.
34. Harding F.A., Allison J.P. CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help. J Exp Med. 177:1993;1791.
35. Gershon R.K., Kondo K. Infectious immunological tolerance. Immunology. 21:1971;903.
36. Gershon R.K., Cohen P., Hencin R., Liebhaber S.A. Suppressor T cells. J Immunol. 108:1972;586.
37. Bloom B.R., Salgame P., Diamond B. Revisiting and revising suppressor T cells. Immunol Today. 13:1992;131.
38. Huber B., Cantor H., Shen F.W., Boyse E.A. Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells experimental production of mice deprived of selected T-cell subclasses. J Exp Med. 144:1976;1128.
39. Koh D.R., Fung-Leung W.P., Ho A., Gray D., Acha-Orbea H., Mak T.W. Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science. 256:1992;1210.
40. Jiang H., Zhang S.I., Pernis B. Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science. 256:1992;1213.
41. Tada Y., Ho A., Koh D.R., Mak T.W. Collagen-induced arthritis in CD4- or CD8-deficient mice CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis . J Immunol. 156:1996;4520.
42. Zhang L., Shannon J., Sheldon J., Teh H.S., Mak T.W., Miller R.G. Role of infused CD8+ cells in the induction of peripheral tolerance. J Immunol. 152:1994;2222.
43. Damle N.K., Mohagheghpour N., Hansen J.A., Engleman E.G. Alloantigen-specific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors. J Immunol. 131:1983;2296.
44. Ciubotariu R., Colovai A.I., Pennesi G., Liu Z., Smith D., Berlocco P., Cortesini R., Suciu-Foca N. Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8+CD28- regulatory T cells. J Immunol. 161:1998;5193.
45. Liu Z., Tugulea S., Cortesini R., Suciu-Foca N. Specific suppression of T helper alloreactivity by allo-MHC class I- restricted CD8+CD28- T cells. Int Immunol. 10:1998;775.
46. Jiang S., Tugulea S., Pennesi G., Liu Z., Mulder A., Lederman S., Harris P., Cortesini R., Suciu-Foca N. Induction of MHC-class I restricted human suppressor T cells by peptide priming in vitro. Hum Immunol. 59:1998;690.
47. Liu Z., Tugulea S., Cortesini R., Lederman S., Suciu-Foca N. Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells. Hum Immunol. 60:1999;568.
48. Klaus S.J., Pinchuk L.M., Ochs H.D., Law C.L., Fanslow W.C., Armitage R.J., Clark E.A. Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. J Immunol. 152:1994;5643.
49. Clark E.A., Ledbetter J.A. How B and T cells talk to each other. Nature. 367:1994;425.
50. Steinman R.M., Inaba K., Turley S., Pierre P., Mellman I. Antigen capture, processing, and presentation by dendritic cells recent cell biological studies . Hum Immunol. 60:1999;562.
51. Laupéze B., Fardel O., Onno M., Bertho N., Drénou B., Fauchet R., Amiot L. Differential expression of major histocompatibility complex class Ia, Ib and II molecules on monocytes and monocyte-derived dendritic and macrophagic cells. Hum Immunol. 60:1999;591.
52. El Ghalbzouri A., Drénou B., Blancheteau V., Choqueux C., Fauchet R., Charron D., Mooney N. An in vitro model of allogenic stimulation of cord blood induction of Fas independent apoptosis . Hum Immunol. 60:1999;598.
53. Das P., Bradley D.S., Geluk A., Griffiths M.M., Luthra H.S., David C.S. An HLA-DRB1*402 derived peptide (HV3 65-79) prevents collagen-induced arthritis in HLA-DQ8 transgenic mice. Hum Immunol. 60:1999;575.
54. Gregersen P.K., Silver J., Winchester R.J. The shared epitope hypothesis an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis . Arthritis Rheum. 30:1987;1205.
55. Abraham R.S., Wilson S.B., deSouza N.F. Jr, Strominger J.L., Munn S.R., David C.S. NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice. Hum Immunol. 60:1999;583.
56. Falcone M., Lee J., Patstone G., Yeung B., Sarvetnick N. B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD 65 antigen in nonobese diabetic mice. J Immunol. 161:1998;1163.
57. Reichstetter S., Kwok W.W., Kochik S., Koelle D.M., Beaty J.S., Nepom G.T. MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition. Hum Immunol. 60:1999;608.
58. Kwok W.W., Reijonen H., Falk B.A., Koelle D.M., Nepom G.T. Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition. Hum Immunol. 60:1999;619.
59. Eardley D.D., Kemp J., Shen F.W., Cantor H., Gershon R.K. Immunoregulatory circuits among T cell sets effect of mode of immunization on determining which Lyl T cell sets will be activated . J Immunol. 122:1979;1663.
60. Evans R.L., Faldetta T.J., Humphreys R.E., Pratt D.M., Yunis E.J., Schlossman S.F. Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens. J Exp Med. 148:1978;1440.
61. Brink R., Lodish H.F. Tumor necrosis factor receptor (TNRF)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kB activation. J Biol Chem. 273:(7):1998;4129.
62. Rothe M., Sarma V., Dixit V.M., Goeddel D.V. TRAF2-mediated activation of NF-kB by TNF Receptor 2 and CD40. Science. 269:1995;1424.
63. Takeuchi M., Rothe M., Goeddel D.V. Anatomy of TRAF2 Distinct domains for nuclear factor-kB activation and association with tumor necrosis factor signaling proteins . J Biol Chem. 271:1996;19935.
64. Dadgostar H., Cheng G. An intact zinc ring finger is required for tumor necrosis factor receptor-associated factor-mediated nuclear factor-kB activation but is dispensable for c-Jun N-terminal kinase signaling. J Biol Chem. 273:1998;24775.
65. van Eyndhoven W.G., Frank D., Kalachikov S., Cleary A.M., Hong D.I., Cho E., Nasr S., Perez A.J., Mackus W.J.M., Cayanis E., Wellington S., Fischer S.G., Warburton D., Lederman S. A single gene for human TRAF-3 at chromosome 14q32 3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation. Mol Immunol. 35:1998;1189.
66. Cerutti A., Schaffer A., Shah S., Zan H., Liou H.C., Goodwin R.G., Casali P. CD30 is a CD40-inducible molecule that negatively regulates CD40- mediated immunoglobulin class switching in non-antigen-selected human B cells. Immunity. 9:1998;247.
67. Heath A.W., Wu W.W., Howard M.C. Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur J Immunol. 24:1994;1828.
68. Parker D.C., Greiner D.L., Phillips N.E., Appel M.C., Steele A.W., Durie F.H., Noelle R.J., Mordes J.P., Rossini A.A. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci USA. 92:1995;9560.
69. Larsen C.P., Elwood E.T., Alexander D.Z., Ritchie S.C., Hendrix R., Tucker-Burden C., Cho H.R., Aruffo A., Hollenbaugh D., Linsley P.S., Winn K.J., Pearson T.C. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 381:1996;434.
70. Hancock W.W., Sayegh M.H., Zheng X.G., Peach R., Linsley P.S., Turka L.A. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci USA. 93:1996;13967.
71. Kirk A.D., Harlan D.M., Armstrong N.N., Davis T.A., Dong Y., Gray G.S., Hong X., Thomas D., Fechner J.H. Jr, Knechtle S.J. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA. 94:1997;8789.
72. Martin P.J., Ledbetter J.A., Morishita Y., June C.H., Beatty P.G., Hansen J.A. A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol. 136:1986;3282.
73. Jenkins M.K., Pardoll D.M., Mizuguchi J., Chused T.M., Schwartz R.H. Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc Natl Acad Sci USA. 84:1987;5409.
74. Tan P., Anasetti C., Hansen J.A., Melrose J., Brunvand M., Bradshaw J., Ledbetter J.A., Linsley P.S. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J Exp Med. 177:1993;165.
75. Shahinian A., Pfeffer K., Lee K.P., Kundig T.M., Kishihara K., Wakeham A., Kawai K., Ohashi P.S., Thompson C.B., Mak T.W. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 261:1993;609.
76. Monteiro J., Batliwalla F., Ostrer H., Gregersen P.K. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J Immunol. 156:1996;3587.
77. Nociari M.M., Telford W., Russo C. Postthymic development of CD28-CD8+ T cell subset age-associated expansion and shift from memory to naive phenotype . J Immunol. 162:1999;3327.
78. Sherman W., Liu Z., Inghirami G., Reed E.F., Harris P.E., Suciu-Foca N.M. Major histocompatibility complex-restricted recognition of autologous chronic lymphocytic leukemia by tumor-specific T cells. Immunol Res. 12:1993;338.
79. Debenedette M.A., Shahinian A., Mak T.W., Watts T.H. Costimulation of CD28- T lymphocytes by 4-1BB ligand. J Immunol. 158:1997;551.
80. Saoulli K., Lee S.Y., Cannons J.L., Yeh W.C., Santana A., Goldstein M.D., Bangia N., Debenedette M.A., Mak T.W., Choi Y., Watts T.H. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4- 1BB ligand. J Exp Med. 187:1998;1849.
81. Agrawal B., Reddish M., Longenecker B.M. CD30 expression on human CD8+ T cells isolated from peripheral blood lymphocytes of normal donors. J Immunol. 157:1996;3229.
82. Telford W.G., Nam S.Y., Podack E.R., Miller R.A. CD30-regulated apoptosis in murine CD8 T cells after cessation of TCR signals. Cell Immunol. 182:1997;125.
83. Aizawa S., Nakano H., Ishida T., Horie R., Nagai M., Ito K., Yagita H., Okumura K., Inoue J., Watanabe T. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J Biol Chem. 272:1997;2042.
84. Boucher L.M., Marengere L.E., Lu Y., Thukral S., Mak T.W. Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily. Biochem Biophys Res Commun. 233:1997;592.
85. Duckett C.S., Gedrich R.W., Gilfillan M.C., Thompson C.B. Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2. Mol Cell Biol. 17:1997;1535.
86. Gedrich R.W., Gilfillan M.C., Duckett C.S., Van Dongen J.L., Thompson C.B. CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. J Biol Chem. 271:1996;12852.
87. Horie R., Aizawa S., Nagai M., Ito K., Higashihara M., Ishida T., Inoue J., Watanabe T. A novel domain in the CD30 cytoplasmic tail mediates NFkappaB activation. Int Immunol. 10:1998;203.
88. Lee S.Y., Kandala G., Liou M.L., Liou H.C., Choi Y. CD30/TNF receptor-associated factor interaction NF-kappa B activation and binding specificity . Proc Natl Acad Sci USA. 93:1996;9699.
89. Gilfillan M.C., Noel P.J., Podack E.R., Reiner S.L., Thompson C.B. Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines. J Immunol. 160:1998;2180.
90. Amakawa R., Hakem A., Kundig T.M., Matsuyama T., Simard J.J., Timms E., Wakeham A., Mittruecker H.W., Griesser H., Takimoto H., Schmits R., Shahinian A., Ohashi P., Penninger J.M., Mak T.W. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell. 84:1996;551.
91. Kurts C., Carbone F.R., Krummell M.F., Koch K.M., Miller J.A.F.P., Heath W.R. Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells. Nature. 398:1999;341.
92. Wendtner C.M., Schmitt B., Gruss H.J., Druker B.J., Emmerich B., Goodwin R.G., Hallek M. CD30 ligand signal transduction involves activation of a tyrosine kinase and of mitogen-activated protein kinase in a Hodgkin's lymphoma cell line. Cancer Res. 55:1995;4157.
93. Wiley S.R., Goodwin R.G., Smith C.A. Reverse signaling via CD30 ligand. J Immunol. 157:1996;3635.
94. Waldmann T.A., Broder S., Krakauer R., MacDermott R.P., Durm M., Goldman C., Meade B. The role of suppressor cells in the pathogenesis of common variable hypogammaglobulinemia and the immunodeficiency associated with myeloma. Fed Proc. 35:1976;2067.
95. de Totero D., Reato G., Mauro F., Cignetti A., Ferrini S., Guarini A., Gobbi M., Grossi C.E., Foa R. IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia. Br J Haematol. 104:1999;589.