ICV vs. VMH injection of leptin: Comparative effects on hypothalamic gene expression

Behavioural Brain Research

Volumn 196, Issue 2, 2009, Pages 279-285

  Ambati, Suresh ^a   Duan, Jiuhua ^a   Choi, Yang Ho ^a   Hartzell, Diane L ^a   Della Fera, Mary Anne ^a   Baile, Clifton A ^a,b  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Fat pad; Feeding; Hypothalamus; mRNA; Neuropeptide; Serum

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; INSULIN; JANUS KINASE 2; MESSENGER RNA; NEUROPEPTIDE; PROOPIOMELANOCORTIN; PROSTAGLANDIN E SYNTHASE; PROTIRELIN; RECOMBINANT LEPTIN; SECRETIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE;

ABDOMINAL FAT ASPIRATION BIOPSY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; FEEDING; FOOD INTAKE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HYPOTHALAMUS; INSULIN BLOOD LEVEL; MALE; MEDIAN EMINENCE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VENTROMEDIAL HYPOTHALAMUS DRUG ADMINISTRATION; ZONA INCERTA;

ANIMALS; ARCUATE NUCLEUS; BODY WEIGHT; CACHEXIA; EATING; GENE EXPRESSION; HYPOTHALAMUS; INFLAMMATION; INJECTIONS; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; MEDIAN EMINENCE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 57549103609     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2008.09.014     Document Type: Article

References (60)

1. Anisman H., and Merali Z. Anhedonic and anxiogenic effects of cytokine exposure. Adv Exp Med Biol 461 (1999) 199-233
2. Asakawa A., Inui A., Yuzuriha H., Nagata T., Kaga T., Ueno N., et al. Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice. Horm Metab Res 33 (2001) 554-558
3. Auernhammer C.J., and Melmed S. The central role of SOCS-3 in integrating the neuro-immunoendocrine interface. J Clin Invest 108 (2001) 1735-1740
4. Beck B. Neuropeptide Y in normal eating and in genetic and dietary-induced obesity. Philos Trans R Soc Lond B Biol Sci 361 (2006) 1159-1185
5. Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., and Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1 (1998) 619-625
6. Brown L.M., Clegg D.J., Benoit S.C., and Woods S.C. Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice. Physiol Behav 89 (2006) 687-691
7. Carlezon Jr. W.A., Duman R.S., and Nestler E.J. The many faces of CREB. Trends Neurosci 28 (2005) 436-445
8. Chaki S., Kawashima N., Suzuki Y., Shimazaki T., and Okuyama S. Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents. Eur J Pharmacol 464 (2003) 49-54
9. Choi Y.H., Li C., Page K., Westby A., Della-Fera M.A., Lin J., et al. Melanocortin receptors mediate leptin effects on feeding and body weight but not adipose apoptosis. Physiol Behav 79 (2003) 795-801
10. Clark K.A., MohanKumar S.M., Kasturi B.S., and MohanKumar P.S. Effects of central and systemic administration of leptin on neurotransmitter concentrations in specific areas of the hypothalamus. Am J Physiol Regul Integr Comp Physiol 290 (2006) R306-R312
11. Coogan A.N., and Piggins H.D. MAP kinases in the mammalian circadian system-key regulators of clock function. J Neurochem 90 (2004) 769-775
12. Dandona P., Weinstock R., Thusu K., Abdel-Rahman E., Aljada A., and Wadden T. Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss. J Clin Endocrinol Metab 83 (1998) 2907-2910
13. Dhandapani K.M., Mahesh V.B., and Brann D.W. Astrocytes and brain function: implications for reproduction. Exp Biol Med (Maywood) 228 (2003) 253-260
14. Dhillon H., Zigman J.M., Ye C., Lee C.E., McGovern R.A., Tang V., et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49 (2006) 191-203
15. Duan J., Choi Y.H., Hartzell D., Della-Fera M.A., Hamrick M., and Baile C.A. Effects of subcutaneous leptin injections on hypothalamic gene profiles in lean and ob/ob mice. Obesity (Silver Spring) 15 (2007) 2624-2633
16. Duff E., Li C.L., Hartzell D.L., Choi Y.H., Della-Fera M.A., and Baile C.A. Ciliary neurotrophic factor injected ICV induces adipose tissue apoptosis in rats. Apoptosis 9 (2004) 629-634
17. Duman C.H., and Duman R.S. Neurobiology and treatment of anxiety: signal transduction and neural plasticity. Handb Exp Pharmacol (2005) 305-334
18. Elefteriou F., Ahn J.D., Takeda S., Starbuck M., Yang X., Liu X., et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434 (2005) 514-520
19. Francis J., MohanKumar S.M., and MohanKumar P.S. Leptin inhibits norepinephrine efflux from the hypothalamus in vitro: role of gamma aminobutyric acid. Brain Res 1021 (2004) 286-291
20. Haack M., Pollmacher T., and Mullington J.M. Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers. Brain Behav Immun 18 (2004) 361-367
21. Hakansson M.L., and Meister B. Transcription factor STAT3 in leptin target neurons of the rat hypothalamus. Neuroendocrinology 68 (1998) 420-427
22. Halaas J.L., Boozer C., Blair-West J., Fidahusein N., Denton D.A., and Friedman J.M. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 94 (1997) 8878-8883
23. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 (1995) 543-546
24. Hamrick M.W., Della Fera M.A., Choi Y.H., Hartzell D., Pennington C., and Baile C.A. Injections of leptin into rat ventromedial hypothalamus increase adipocyte apoptosis in peripheral fat and in bone marrow. Cell Tissue Res 327 (2007) 133-141
25. Hauner H., Bender M., Haastert B., and Hube F. Plasma concentrations of soluble TNF-alpha receptors in obese subjects. Int J Obes Relat Metab Disord 22 (1998) 1239-1243
26. Hay-Schmidt A., Helboe L., and Larsen P.J. Leptin receptor immunoreactivity is present in ascending serotonergic and catecholaminergic neurons of the rat. Neuroendocrinology 73 (2001) 215-226
27. Hebenstreit D., Horejs-Hoeck J., and Duschl A. JAK/STAT-dependent gene regulation by cytokines. Drug News Perspect 18 (2005) 243-249
28. Hubschle T., Thom E., Watson A., Roth J., Klaus S., and Meyerhof W. Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J Neurosci 21 (2001) 2413-2424
29. Hugues J.N., Miro F., Smyth C.D., and Hillier S.G. Effects of growth hormone releasing hormone on rat ovarian steroidogenesis. Hum Reprod 11 (1996) 50-54
30. Jacob R.J., Dziura J., Medwick M.B., Leone P., Caprio S., During M., et al. The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus. Diabetes 46 (1997) 150-152
31. Kagaya A., Kugaya A., Takebayashi M., Fukue-Saeki M., Saeki T., Yamawaki S., et al. Plasma concentrations of interleukin-1beta, interleukin-6, soluble interleukin-2 receptor and tumor necrosis factor alpha of depressed patients in Japan. Neuropsychobiology 43 (2001) 59-62
32. Kalra S.P., Dube M.G., Sahu A., Phelps C.P., and Kalra P.S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA 88 (1991) 10931-10935
33. Kang H.J., Adams D.H., Simen A., Simen B.B., Rajkowska G., Stockmeier C.A., et al. Gene expression profiling in postmortem prefrontal cortex of major depressive disorder. J Neurosci 27 (2007) 13329-13340
34. Levin E., Kleeman C.R., and Villamil M.F. Influence of routes of administration on distribution of substances in the brain. Am J Physiol 223 (1972) 763-769
35. Levin N., Nelson C., Gurney A., Vandlen R., and de Sauvage F. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA 93 (1996) 1726-1730
36. Maness L.M., Kastin A.J., Farrell C.L., and Banks W.A. Fate of leptin after intracerebroventricular injection into the mouse brain. Endocrinology 139 (1998) 4556-4562
37. Meister B. Control of food intake via leptin receptors in the hypothalamus. Vitam Horm 59 (2000) 265-304
38. Muzumdar R., Ma X., Yang X., Atzmon G., Bernstein J., Karkanias G., et al. Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB J 17 (2003) 1130-1132
39. Oektedalen O., Opstad P.K., and Schaffalitzky de Muckadell O.B. Secretin-a new stress hormone?. Regul Pept 4 (1982) 213-219
40. Palkovits M., and Brownstein MJ. Maps and guide to microdissection of the rat brain (1988), Elsevier, New York
41. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates (1986), Elsevier, New York
42. In: Paxinos G., and Watson C (Eds). The rat brain in stereotaxic coordinates (1998), Academic Press, San Diego
43. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 (1995) 540-543
44. Pralong F.P., and Gaillard R.C. Neuroendocrine effects of leptin. Pituitary 4 (2001) 25-32
45. Rivest S. Does circulating leptin have the ability to cross the blood-brain barrier and target neurons directly?. Endocrinology 143 (2002) 3211-3213
46. Sakamaki K., Nomura M., Yamato K., and Tanaka J. GABA-mediated attenuation of noradrenaline release in the rat median preoptic area caused by intravenous injection of metaraminol. Auton Neurosci 111 (2004) 7-14
47. Sandberg E.M., Ma X., VonDerLinden D., Godeny M.D., and Sayeski P.P. Jak2 tyrosine kinase mediates angiotensin II-dependent inactivation of ERK2 via induction of mitogen-activated protein kinase phosphatase 1. J Biol Chem 279 (2004) 1956-1967
48. Sands S.A., Strong R., Corbitt J., and Morilak D.A. Effects of acute restraint stress on tyrosine hydroxylase mRNA expression in locus coeruleus of Wistar and Wistar-Kyoto rats. Brain Res Mol Brain Res 75 (2000) 1-7
49. Satoh N., Ogawa Y., Katsuura G., Hayase M., Tsuji T., Imagawa K., et al. The arcuate nucleus as a primary site of satiety effect of leptin in rats. Neurosci Lett 224 (1997) 149-152
50. Shimabukuro M., Koyama K., Chen G., Wang M.Y., Trieu F., Lee Y., et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94 (1997) 4637-4641
51. Shioda S., Funahashi H., Nakajo S., Yada T., Maruta O., and Nakai Y. Immunohistochemical localization of leptin receptor in the rat brain. Neurosci Lett 243 (1998) 41-44
52. Siegel J.M. Narcolepsy: a key role for hypocretins (orexins). Cell 98 (1999) 409-412
53. Soukas A., Cohen P., Socci N.D., and Friedman J.M. Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev 14 (2000) 963-980
54. Sweatt J.D. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76 (2001) 1-10
55. Sweet D.C., Levine A.S., Billington C.J., and Kotz C.M. Feeding response to central orexins. Brain Res 821 (1999) 535-538
56. In: Ur E (Ed). Neuroendocrinology of leptin: frontiers in hormone research vol. 26 (2000), Basel, Karger 125 pp
57. Utsunomiya K., Yanagihara N., Tachikawa E., Cheah T.B., Kajiwara K., Toyohira Y., et al. Stimulation of catecholamine synthesis in cultured bovine adrenal medullary cells by leptin. J Neurochem 76 (2001) 926-934
58. Van Houten M., and Posner B.I. Circumventricular organs: receptors and mediators of direct peptide hormone action on brain. Adv Metab Disord 10 (1983) 269-289
59. Welch M.G., Keune J.D., Welch-Horan T.B., Anwar N., Anwar M., Ludwig R.J., et al. Secretin: hypothalamic distribution and hypothesized neuroregulatory role in autism. Cell Mol Neurobiol 24 (2004) 219-241
60. Xu B., Dube M.G., Kalra P.S., Farmerie W.G., Kaibara A., Moldawer L.L., et al. Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology 139 (1998) 466-473