Sonic hedgehog and CDX2 expression in the stomach

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue SUPPL. 2, 2008, Pages

  Shiotani, Akiko ^a   Kamada, Tomoari ^a   Yamanaka, Yoshiyuki ^a   Manabe, Noriaki ^a   Kusunoki, Hiroaki ^a   Hata, Jiro ^a   Haruma, Ken ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

CDX2; Gastric cancer; Helicobacter pylori; Intestinal metaplasia; Sonic hedgehog (Shh)

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR CDX2;

ATROPHIC GASTRITIS; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONFERENCE PAPER; EMBRYO DEVELOPMENT; HELICOBACTER PYLORI; HUMAN; INTESTINE METAPLASIA; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STOMACH CANCER;

EID: 57449108297     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2008.05406.x     Document Type: Conference Paper

References (68)

1. Graham DY, Shiotani A. The time to eradicate gastric cancer is now. Gut 2005 54 : 735 8.
2. Shiotani A, Iishi H, Uedo N et al. Histologic and serum risk markers for noncardia early gastric cancer. Int. J. Cancer 2005 115 : 463 9.
3. Sipponen P, Kimura K. Intestinal metaplasia, atrophic gastritis and stomach cancer: trends over time. Eur. J. Gastroenterol. Hepatol. 1994 6 (Suppl. 1 S79 83.
4. Uemura N, Okamoto S, Yamamoto S et al. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 2001 345 : 784 9.
5. Shiotani A, Haruma K, Uedo N et al. Histological risk markers for non-cardia early gastric cancer: pattern of mucin expression and gastric cancer. Virchows Arch. 2006 449 : 652 9.
6. Shiotani A, Iishi H, Uedo N et al. Evidence that loss of sonic hedgehog is an indicator of Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer. Am. J. Gastroenterol. 2005 100 : 581 7.
7. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process. First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992 52 : 6735 40.
8. Egashira Y, Shimoda T, Ikegami M. Mucin histochemical analysis of minute gastric differentiated adenocarcinoma. Pathol. Int. 1999 49 : 55 61.
9. Saito A, Shimoda T, Nakanishi Y, Ochiai A, Toda G. Histologic heterogeneity and mucin phenotypic expression in early gastric cancer. Pathol. Int. 2001 51 : 165 71.
10. Hammerschmidt M, Brook A, McMahon AP. The world according to hedgehog. Trends Genet. 1997 13 : 14 21.
11. Bitgood MJ, McMahon AP. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 1995 172 : 126 38.
12. Echelard Y, Epstein DJ, St-Jacques B et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993 75 : 1417 30.
13. Macdonald PM, Struhl G. A molecular gradient in early Drosophila embryos and its role in specifying the body pattern. Nature 1986 324 : 537 45.
14. Moreno E, Morata G. Caudal is the Hox gene that specifies the most posterior Drosophile segment. Nature 1999 400 : 873 7.
15. Silberg DG, Swain GP, Suh ER, Traber PG. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000 119 : 961 71.
16. Shiotani A, Iishi H, Uedo N et al. Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression. Aliment. Pharmacol. Ther. 2006 24 (Suppl. 4 71 80.
17. Shiotani A, Uedo N, Iishi H et al. Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia. Int. J. Cancer 2007 15 : 1182 9.
18. Fukaya M, Isohata N, Ohta H et al. Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology 2006 131 : 14 29.
19. Lee SY, Han HS, Lee KY et al. Sonic hedgehog expression in gastric cancer and gastric adenoma. Oncol. Rep. 2007 17 : 1051 5.
20. Mizoshita T, Tsukamoto T, Inada K et al. Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa. Pathol. Int. 2004 54 : 392 400.
21. Bai Y, Akiyama Y, Nagasaki HY et al. Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines. Mol. Carcinog. 2000 28 : 184 8.
22. Almeida R, Silva E, Santos-Silva F et al. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J. Pathol. 2003 199 : 36 40.
23. Roberts DJ, Smith DM, Goff DJ, Tabin CJ. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development 1998 125 : 2791 801.
24. Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980 287 : 795 801.
25. Katoh Y, Katoh M. Hedgehog signaling pathway and gastrointestinal stem cell signaling network (Review). Int. J. Mol. Med. 2006 18 : 1019 23.
26. Ramalho-Santos M. Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 2000 127 : 2763 72.
27. Litingtung Y, Lei L, Westphal H, Chiang C. Sonic hedgehog is essential to foregut development. Nat. Genet. 1998 20 : 58 61.
28. van den Brink GR, Hardwick JC, Nielsen C et al. Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut 2002 51 : 628 33.
29. van den Brink GR, Hardwick JC, Tytgat GN et al. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology 2001 121 : 317 28.
30. Oldak M, Grzela T, Lazarczyk M, Malejczyk J, Skopinski P. Clinical aspects of disrupted Hedgehog signaling (Review). Int. J. Mol. Med. 2001 8 : 445 52.
31. Faller G, Kirchner T. Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia. Virchows Arch. 2005 446 : 1 9.
32. Jacob J, Briscoe J. Gli proteins and the control of spinal-cord patterning. EMBO Rep. 2003 4 : 761 5.
33. Teh MT, Wong ST, Neill GW, Ghali LR, Philpott MP, Quinn AG. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res. 2002 62 : 4773 80.
34. James R, Erler T, Kazenwadel J. Structure of the murine homeobox gene cdx-2: expression in embryonic and adult intestinal epithelium. J. Biol. Chem. 1994 269 : 15229 37.
35. Beck F, Chawengsaksophak K, Waring P, Playford RJ, Furness JB. Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc. Natl. Acad. Sci. USA 1999 96 : 7318 23.
36. Phillips RW, Frierson HF Jr, Moskaluk CA. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am. J. Surg. Pathol. 2003 27 : 1442 7.
37. Silberg DG, Sullivan J, Kang E et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 2002 122 : 689 96.
38. Fukamachi H, Ito K, Ito Y. Runx3-/- gastric epithelial cells differentiate into intestinal type cells. Biochem. Biophys. Res. Commun. 2004 321 : 58 64.
39. Hinoi T, Lucas PC, Kuick R, Hanash S, Cho KR, Fearon ER. CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology 2002 123 : 1565 77.
40. Correa P. Helicobacter pylori and gastric carcinogenesis. Am. J. Surg. Pathol. 1995 19 (Suppl. 1 S37 43.
41. Kimura K, Satoh K, Ido K, Taniguchi Y, Takimoto T, Takemoto T. Gastritis in the Japanese stomach. Scand. J. Gastroenterol. Suppl. 1996 214 : 17 20 discussion 21 3.
42. El-Zimaity HM, Ota H, Graham DY, Akamatsu T, Katsuyama T. Patterns of gastric atrophy in intestinal type gastric carcinoma. Cancer 2002 94 : 1428 36.
43. Filipe MI, Potet F, Bogomoletz WV et al. Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres. Gut 1985 26 : 1319 26.
44. Tsukamoto T, Inada K, Tanaka H et al. Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal- mixed to complete intestinal metaplasia. J. Cancer Res. Clin. Oncol. 2004 130 : 135 45.
45. Tsukamoto T, Mizoshita T, Mihara M et al. Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes. Histopathology 2005 46 : 649 58.
46. Tatematsu M, Tsukamoto T, Inada K. Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci. 2003 94 : 135 41.
47. Inada K, Tanaka H, Nakanishi H et al. Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed-type intestinal metaplasia of the human stomach. Virchows Arch. 2001 439 : 14 20.
48. Tanaka H, Tsukamoto T, Mizoshita T et al. Expression of small intestinal and colonic phenotypes in complete intestinal metaplasia of the human stomach. Virchows Arch. 2005 447 : 806 15.
49. Filipe MI, Barbatis C, Sandey A, Ma J. Expression of intestinal mucin antigens in the gastric epithelium and its relationship with malignancy. Hum. Pathol. 1988 19 : 19 26.
50. Matsukura N, Suzuki K, Kawachi T et al. Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation to complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. J. Natl. Cancer Inst. 1980 65 : 231 40.
51. Rokkas T, Filipe MI, Sladen GE. Detection of an increased incidence of early gastric cancer in patients with intestinal metaplasia type III who are closely followed up. Gut 1991 32 : 1110 13.
52. Filipe MI, Munoz N, Matko I et al. Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int. J. Cancer 1994 57 : 324 9.
53. Dinis-Ribeiro M, Lopes C, da Costa-Pereira A et al. A follow up model for patients with atrophic chronic gastritis and intestinal metaplasia. J. Clin. Pathol. 2004 57 : 177 82.
54. Jass JR, Filipe MI. The mucin profiles of normal gastric mucosa, intestinal metaplasia and its variants and gastric carcinoma. Histochem. J. 1981 13 : 931 9.
55. Stepan V, Ramamoorthy S, Nitsche H, Zavros Y, Merchant JL, Todisco A. Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. J. Biol. Chem. 2005 280 : 15700 8.
56. Dimmler A, Brabletz T, Hlubek F et al. Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is up-regulated in acidic conditions. Lab. Invest. 2003 83 : 1829 37.
57. Faller G, Dimmler A, Rau T et al. Evidence for acid-induced loss of Cdx2 expression in duodenal gastric metaplasia. J. Pathol. 2004 203 : 904 8.
58. Wong BC, Lam SK, Wong WM et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA 2004 291 : 187 94.
59. Berman DM, Karhadkar SS, Hallahan AR et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002 297 : 1559 61.
60. Berman DM, Karhadkar SS, Maitra A et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003 425 : 846 51.
61. Watkins DN, Berman DM, Burkholder SG et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003 422 : 313 17.
62. Mizoshita T, Tsukamoto T, Nakanishi H et al. Expression of Cdx2 and the phenotype of advanced gastric cancers: relationship with prognosis. J. Cancer Res. Clin. Oncol. 2003 129 : 727 34.
63. Mutoh H, Sakurai S, Satoh K et al. Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. Cancer Res. 2004 64 : 7740 7.
64. Tatematsu M, Furihata C, Katsuyama T et al. Independent induction of intestinal metaplasia and gastric cancer in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine. Cancer Res. 1983 43 : 1335 41.
65. Mizoshita T, Inada K, Tsukamoto T et al. Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells. J. Cancer Res. Clin. Oncol. 2004 130 : 29 36.
66. Bai YQ, Miyake S, Iwai T, Yuasa Y. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2003 22 : 7942 9.
67. Yuasa Y. Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat. Rev. Cancer 2003 3 : 592 600.
68. Seno H, Oshima M, Taniguchi MA et al. CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: prognostic implications. Int. J. Oncol. 2002 21 : 769 74.