Fipronil-induced disruption of thyroid function in rats is mediated by increased total and free thyroxine clearances concomitantly to increased activity of hepatic enzymes

Toxicology

Volumn 255, Issue 1-2, 2009, Pages 38-44

  Leghait, Julien ^a   Gayrard, Véronique ^a   Picard Hagen, Nicole ^a   Camp, Marion ^a   Perdu, Elisabeth ^b   Toutain, Pierre Louis ^a   Viguié, Catherine ^a  

^a CEMAGREF   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

5 Amino 1 2,6 dichloro 4 (trifluoromethyl)phenyl 4 (trifluoromethylsu lfinyl) 1H pyrazole 3 carbonitrile; Clearance; Fipronil; Rat; Thyroid disruptor; UDPGT

Indexed keywords

4 NITROPHENOL; CYTOCHROME P450; FIPRONIL; GLUCURONOSYLTRANSFERASE; LIOTRIX; LIVER ENZYME; PHENAZONE; THYROTROPIN; THYROXINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLUCURONIDATION; LIVER MICROSOME; METABOLITE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; THYROID FUNCTION; THYROIDECTOMY; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRINE; ENDOCRINE DISRUPTORS; FEMALE; GLUCURONOSYLTRANSFERASE; HALF-LIFE; INSECTICIDES; LIVER; PYRAZOLES; RATS; RATS, WISTAR; THYROID FUNCTION TESTS; THYROID GLAND; THYROID HORMONES; THYROTROPIN; THYROXINE;

RATTUS;

EID: 57449083768     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.09.026     Document Type: Article

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