Alphaxalone, a neurosteroid anaesthetic, increases the activity of the glutamate transporter type 3 expressed in Xenopus oocytes

European Journal of Pharmacology

Volumn 602, Issue 1, 2009, Pages 23-27

  Ryu, Junghee ^a   Cheong, Il Young ^b   Do, Sang Hwan ^a,d   Zuo, Zhiyi ^c  

^a Seoul National University Bundang Hospital   (South Korea)

^b Kangwon National University   (South Korea)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^d Seoul National University College of Medicine   (South Korea)

Author keywords

Alphaxalone; Excitatory amino acid transporter type 3; Glutamate transporter; Phosphatidylinositol 3 kinase; Protein kinase C; Xenopus oocyte

Indexed keywords

ALFAXALONE; CHELERYTHRINE; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMIC ACID; MESSENGER RNA; NEUROSTEROID; PHORBOL 12 ACETATE 13 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; STAUROSPORINE; WORTMANNIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; FEMALE; MEMBRANE CURRENT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; XENOPUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANESTHETICS; ANIMALS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID TRANSPORTER 3; GENE EXPRESSION; NEUROTRANSMITTER AGENTS; OOCYTES; PATCH-CLAMP TECHNIQUES; PREGNANEDIONES; PROTEIN KINASE C; TETRADECANOYLPHORBOL ACETATE; XENOPUS;

EID: 57249104701     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.10.063     Document Type: Article

References (40)

1. Baker M.T., and Naguib M. Propofol: the challenges of formulation. Anesthesiology 103 (2005) 860-876
2. Cantrell D.A. Phosphoinositide 3-kinase signalling pathways. J. Cell. Sci. 114 (2001) 1439-1445
3. Casado M., Bendahan A., Zafra F., Danbolt N.C., Aragon C., Gimenez C., and Kanner B.I. Phosphorylation and modulation of brain glutamate transporters by protein kinase C. J. Biol. Chem. 268 (1993) 27313-27317
4. Child K.J., Currie J.P., Dis B., Dodds M.G., Pearce D.R., and Twissell D.J. The pharmacological properties in animals of CT1341: a new steroid anaesthetic agent. Br. J. Anaesth. 43 (1971) 2-13
5. Choi D.W., Maulucci-Gedde M., and Kriegstein A.R. Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7 (1987) 357-368
6. Compagnone N.A., and Mellon S.H. Neurosteroids: biosynthesis and function of these novel neuromodulators. Front. Neuroendocrinol. 21 (2000) 1-56
7. A receptor activity by alphaxalone. Br. J. Pharmacol. 90 (1987) 491-500
8. Danbolt N.C. Glutamate uptake. Prog. Neurobiol. 65 (2001) 1-105
9. Danbolt N.C., Chaudhry F.A., Dehnes Y., Lehre K.P., Levy L.M., Ullensvang K., and Storm-Mathisen J. Properties and localization of glutamate transporters. Prog. Brain. Res. 116 (1998) 23-43
10. Davis K.E., Straff D.J., Weinstein E.A., Bannerman P.G., Correale D.M., and Rothstein J.D. Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. J. Neurosci. 18 (1998) 2475-2485
11. Deutsch S.I., Rosse R.B., Steinberg K., Morn C., Koetzner L., Riggs R., and Mastropaolo J. Evaluation of in vivo interactions in mice between flurazepam and two neuroactive steroids. Pharmacol. Biochem. Behav. 55 (1996) 323-326
12. Do S.H., Fang H.Y., Ham B.M., and Zuo Z. The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase. Anesth. Analg. 95 (2002) 1263-1268
13. Do S.H., Kamatchi G.L., Washington J.M., and Zuo Z. Effects of volatile anesthetics on glutamate transporter, excitatory amino acid transporter type 3. The role of protein kinase C. Anesthesiology 96 (2002) 1492-1497
14. Do S.H., Ham B.M., and Zuo Z. Effects of propofol on the activity of rat glutamate transporter type 3 expressed in Xenopus oocytes: the role of protein kinase C. Neurosci. Lett. 343 (2003) 113-116
15. Gorter J.A., Van Vliet E.A., Proper E.A., DeGraan P.N., Ghijsen W.E., Lopes Da Silva F.H., and Aronica Ee. Glutamate transporters alterations in the reorganizing dentate gyrus are associated with progressive seizure activity in chronic epileptic rats. J. Comp. Neurol. 442 (2002) 365-377
16. Greene J.G., and Greenamyre J.T. Manipulation of membrane potential modulates malonate-induced striatal excitotoxicity in vivo. J. Neurochem. 66 (1996) 637-643
17. Hansen S.L., Sperling B.B., and Sanchez C. Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 28 (2004) 105-113
18. Harrison N.L., and Simmonds M.A. Modulation of the GABA receptor complex by a steroid anaesthetic. Brain. Res. 323 (1984) 287-292
19. Harrison N.L., Vicini S., and Barker J.L. A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons. J. Neurosci. 7 (1987) 604-609
20. Herbert J.M., Augereau J.M., Gleye J., and Maffrand J.P. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 172 (1990) 993-999
21. Holzbauer M. Physiological aspects of steroids with anaesthetic properties. Med. Biol. 54 (1976) 227-242
22. Horishita T., Minami K., Yanagihara N., Shiraishi M., Okamoto T., Shiga Y., Ueno S., and Shigematsu A. Alphaxalone, a neurosteroid anesthetic, inhibits norepinephrine transporter function in cultured bovine adrenal medullary cells. Anesth. Analg. 95 (2002) 1661-1666
23. Huang Y., and Zuo Z. Isoflurane induces a protein kinase C alphadependent increase in cell surface protein level and activity of glutamate transporter type 3. Mol. Pharmacol. 67 (2005) 1522-1533
24. Larsen M., Hegstad E., Berg-Johnsen J., and Langmoen I.A. Isoflurane increases the uptake of glutamate in synaptosomes from rat cerebral cortex. Br. J. Anaesth. 78 (1997) 55-94
25. Matsumoto H., and Sasaki Y. Staurosporine, a protein kinase C inhibitor interferes with proliferation of arterial smooth muscle cells. Biochem. Biophys. Res. Commun. 158 (1989) 105-109
26. Minami K., Vanderah T.W., Minami M., and Harris R.A. Inhibitory effects of anesthetics and ethanol on muscarinic receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 339 (1997) 237-244
27. Miyazaki H., Nakamura Y., Arai T., and Kataoka K. Increase of glutamate uptake in astrocytes: a possible mechanism of action of volatile anesthetics. Anesthesiology 86 (1997) 1359-1366
28. Nilsson P., Laursen H., Hillered L., and Hansen A.J. Calcium movements in traumatic brain injury: the role of glutamate receptor-operated ion channels. J. Cereb. Blood Flow. Metab. 16 (1996) 262-270
29. Palmer A.M., Marion D.W., Botscheller M.L., Swedlow P.E., Styren S.D., and DeKosky S.T. Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. J. Neurochem. 61 (1993) 2015-2024
30. Rothstein J.D., Van Kammen M., Levey A.I., Martin L.J., and Kuncl R.W. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 38 (1995) 73-84
31. Sepkuty J.P., Cohen A.S., Eccles C., Rafiq A., Behar K., Ganel R., Coulter D.A., and Rothstein J.D. A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. J. Neurosci. 22 (2002) 6372-6379
32. Shiraishi M., Minami K., Shibuya I., Uezono Y., Ogata J., Okamoto T., Murasaki O., Kaibara M., Ueta Y., and Shigematsu A. The inhibitory effects of alphaxalone on M1 and M3 muscarinic receptors expressed in Xenopus oocytes. Anesth. Analg. 97 (2003) 449-455
33. Shiraishi M., Shibuya I., Minami K., Uezono Y., Okamoto T., Yanagihara N., Ueno S., Ueta Y., and Shigematsu A. A neurosteroid anesthetic, alphaxalone, inhibits nicotinic acetylcholine receptors in cultured bovine adrenal chromaffin cells. Anesth. Analg. 95 (2002) 900-906
34. Simantov R., Crispino M., Hoe W., Broutman G., Tocco G., Rothstein J.D., and Baudry M. Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity. Brain Res. Mol. Brain Res. 65 (1999) 112-123
35. Stock J.P.P. A brief history of steroid anaesthesia before Althesin (CT1341). Postgrad. Med. J. 4 (1973) 495
36. Sumikawa K., Matsumoto T., Ishizaka N., Nagai H., Amenomori Y., and Amakata Y. Selective actions of intravenous anesthetics on nicotinic- and muscarinic receptor- mediated responses of the dog adrenal medulla. Anesthesiology 59 (1983) 412-416
37. Tanaka K., Watase K., Manabe T., Yamada K., Watanabe M., Takahashi K., Iwama H., Nishikawa T., Ichihara T., Kikuchi T., Okuyama S., Kawashima N., Hori S., Takimoto M., and Wada K. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276 (1997) 1699-1702
38. Toker A., and Cantley L.C. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387 (1997) 673-676
39. Yun J.Y., Kim J.H., Kim H.K., Lim Y.J., Do S.H., and Zuo Z. Effects of intravenous anesthetics on the activity of glutamate transporter EAAT3 expressed in Xenopus oocytes: Evidence for protein kinase C involvement. Eur. J. Pharmacol. 531 (2006) 133-139
40. Winte L., Nadeson R., Tucker A.P., and Goodchild C.S. Antinociceptive properties of neurosteroids: a comparison of alphadolone and alphaxalone in potentiation of opioid antinociception. Anesth. Analg. 97 (2003) 798-805