Evaluation of in vivo interactions in mice between flurazepam and two neuroactive steroids

Pharmacology Biochemistry and Behavior

Volumn 55, Issue 3, 1996, Pages 323-326

  Deutsch, S I ^a,b   Rosse, R B ^a,b   Steinberg, K ^a   Morn, C ^a   Koetzner, L ^a   Riggs, R ^a   Mastropaolo, J ^a  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

GABA; Neuroactive steroids; Rotorod; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; ANTICONVULSIVE AGENT; ELTANOLONE; FLURAZEPAM; STEROID;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; ATAXIA; CONTROLLED STUDY; CONVULSION; DRUG POTENTIATION; HINDLIMB; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TONIC SEIZURE;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; DRUG INTERACTIONS; ELECTRIC STIMULATION; FLURAZEPAM; GABA MODULATORS; HYPNOTICS AND SEDATIVES; MALE; MICE; MOTOR ACTIVITY; PREGNANEDIONES; PREGNANOLONE; RECEPTORS, GABA-A; SEIZURES;

ANIMALIA; ATAXIA;

EID: 0030297183     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00100-1     Document Type: Article

References (10)

1. 1. Deutsch, S. I.; Mastropaolo, J. Discriminative stimulus properties of midazolam are shared by a GABA-receptor positive steroid. Pharmacol. Biochem. Behav. 46(4):963-965; 1993.
2. 2. Deutsch, S. I.; Mastropaolo, J.; Hitri, A. GABA-active steroids: Endogenous modulators of GABA-gated chloride ion conductance. Clin. Neuropharmacol. 15(5):352-364; 1992.
3. 3. Deutsch, S. I.; Park, C. H.; Hitri, A. Allosteric effects of a GABA receptor-active steroid are altered by stress. Pharmacol. Biochem. Behav. 47(4):913-917; 1994.
4. 4. Deutsch, S. I.; Rosse, R. B.; Huntzinger, J. A.; Novitzki, M. R.; Mastropaolo, J. Profound stress-induced alterations in flurazepam's antiseizure efficacy can be attenuated. Brain Res. 520:272-276; 1990.
5. A receptor. Eur. J. Pharmacol. 269:157-163; 1994.
6. 6. Kokate, T. G.; Svensson, B. E.; Rogawski, M. A. Anticonvulsant activity of neurosteroids: Correlation with gamma-aminobutyric acid-evoked chloride current potentiation. J. Pharmacol. Exp. Ther. 270(3):1223-1229; 1994.
7. A receptor function. Trends Pharmacol. Sci. 16:295-303; 1995.
8. 8. Mellon, S. H. Neurosteroids: Biochemistry, modes of action, and clinical relevance. J. Clin. Endocrinol. Metab. 78(5):1003-1008; 1994.
9. 9. Norris, D. O.; Mastropaolo, J.; O'Connor, D. A.; Cohen, J. M.; Deutsch, S. I. A glycinergic intervention potentiates the antiseizure efficacies of MK-801, flurazepam, and carbamazepine. Neurochem. Res. 19(2):161-165; 1994.
10. beta-pregnan-20-one in rodents. Psychopharmacology (Berlin) 118(1):65-71; 1995.