Colchicine, d-penicillamine, and prednisone in the treatment of idiopathic pulmonary fibrosis: A controlled clinical trial

Chest

Volumn 114, Issue 2, 1998, Pages 507-512

  Selman, Moisés ^a   Carrillo, Guillermo ^a   Salas, Jorge ^a   Pérez Padilla, Rogelio ^a   Pérez Chavira, Rosario ^a   Sansores, Raúl ^a   Chapela, Rocío ^a  

^a INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

Author keywords

Colchicine; D penicillamine; Fibrosing alveolitis; Idiopathic pulmonary fibrosis; Prednisone corticosteroids

Indexed keywords

COLCHICINE; PENICILLAMINE; PREDNISONE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DRUG EFFICACY; DYSPNEA; GASTRITIS; HUMAN; HYPERGLYCEMIA; LUNG FIBROSIS; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MUSCLE WEAKNESS; OSTEOPOROSIS; PEPTIC ULCER; PRIORITY JOURNAL; SURVIVAL; TREATMENT OUTCOME;

EID: 0031842059     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.114.2.507     Document Type: Article

References (25)

1. Selman M. Pulmonary fibrosis: human and experimental disease. In: Rojkind M, ed. Focus on connective tissue in health and disease (vol 1). Boca Raton, Fla: CRC Press, 1989; 123-80
2. Hunninghake GW, Kalica AR. Approaches to the treatment of pulmonary fibrosis. Am J Respir Crit Care Med 1995; 151:915-18
3. Pérez-Padilla R, Salas J, Chapela R, et al. Mortality in Mexican patients with chronic pigeon breeders lung compared to those with usual interstitial pneumonia. Am Rev Respir Dis 1993; 148:49-53
4. Turner-Warwick M, Burrows B, Johnson A. Cryptogenic fibrosing alveolitis: clinical features and their influence on survival. Thorax 1996; 35:171-80
5. Meyer KC, Raghu G. Perspectives and future advances on the diagnosis and treatment of idiopathic pulmonary fibrosis. In: Phan SE, Thrall RS, eds. Pulmonary fibrosis: lung biology in health and disease (vol 80). New York: Marcel Dekker, 1995; 837-74
6. Douglas WW, Ryu JH, Bjoraker JA, et al. Colchicine versus prednisone as treatment of usual interstitial pneumonia. Mayo Clin Proc 1997; 72:201-09
7. Ehrlich HP, Bornstein P. Microtubules in transcellular movement of procollagen. Nature 1972; 238:257-60
8. Bauer EA, Valle KJ. Colchicine-induced modulation of collagenase in human skin fibroblast-cultures: I. Stimulation of enzyme synthesis in normal cells. J Invest Dermatol 1982; 79:398-403
9. Rennard SI, Bitterman PB, Ozaki T, et al. Colchicine suppresses the release of fibroblast growth factors from alveolar macrophages in vitro: the basis of a possible therapeutic approach to the fibrotic disorders. Am Rev Respir Dis 1988; 137:181-85
10. Steen VD, Medsger TAJ, Rodnan GP. D-penicillamine therapy in progressive systemic sclerosis: a retrospective analysis. Ann Intern Med 1982; 97:652-59
11. Quanjer PH, ed. Standardized lung function testing. Bull Eur Physiopathol Respir 1983; 19(suppl)5:1-95
12. Steinberg D, Colla P. SURVIVAL: a supplementary module for SYSTAT. Evanston, Ill: SYSTAT, 1988
13. Panos RJ, King TE. Idiopathic pulmonary fibrosis. In: Lynch JP, DeRemee RA, eds. Immunologically mediated pulmonary diseases. Philadelphia: Lippincott, 1991; 1-39
14. Izumi T, Nagai S, Kondo Y, et al. Ten-year follow up of 222 patients with idiopathic pulmonary fibrosis. Am Rev Respir Dis 1992; 145:A218
15. Johnson MA, Kwan S, Snell NJC, et al. Randomised controlled trial comparing prednisolone alone with cyclophosphamide and low dose prednisolone in combination in cryptogenic fibrosing alveolitis. Thorax 1989; 44:280-88
16. Raghu G, Depaso WJ, Cain K, et al. Azathioprine combined with prednisone in the treatment of idiopathic pulmonary fibrosis: a prospective double-blind, randomized, placebo-controlled trial. Am Rev Respir Dis 1991; 144:291-96
17. Herbert CM, Lindberg KA, Jayson MIV, et al. Biosynthesis and maturation of skin collagen in scleroderma and effect of D-penicillamine. Lancet 1974; 1:187-92
18. Uitto J, Helin P, Rasmussen O, et al. Skin collagen in patients with scleroderma: biosynthesis and maturation in vitro, and the effect of D-penicillamine. Ann Clin Res 1970; 2:228-34
19. Fedullo AJ, Karlinsky JB, Snider GL, et al. Lung status and connective tissues after penicillamine in bleomycin treated hamsters. J Appl Physiol 1980; 49:1083-90
20. Geismar LS, Hennessey S, Reiser KM, et al. D-penicillamine prevents collagen accumulation in lungs of rats given bleomycin. Chest 1986; 89(suppl):153S-54S
21. Goodman M, Knight RK, Turner-Warwick M. Pilot studies of penicillamine therapy in steroid failure patients with interstitial lung disease. In: Maini RN, Berry H, eds. Modulation of autoimmunity and disease. Prague: Praeger, 1981; 291-300
22. Chapela R, Zuñiga G, Selman M. D-penicillamine in the therapy of fibrotic lung diseases. Int J Clin Pharmacol Ther Toxicol 1986; 24:16-19
23. Kershenobich D, Vargas F, García-Tsao G, et al. Colchicine in the treatment of cirrhosis of the liver. N Engl J Med 1988; 318:1709-13
24. Entzian P, Schlaak M, Seitzer U, et al. Anti-inflammatory and antifibrotic properties of colchicine: implications for idiopathic pulmonary fibrosis. Lung 1977; 175:41-51
25. Peters SG, McDougall JC, Douglas WW, et al. Colchicine in the treatment of pulmonary fibrosis. Chest 1993; 103: 101-04