-
1
-
-
0037437764
-
Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity. Effect of yessotoxin on cAMP levels in human lymphocytes
-
Alfonso A, de la Rosa L, Vieytes MR, Yasumoto T, Botana LM. 2003. Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity. Effect of yessotoxin on cAMP levels in human lymphocytes. Biochem Pharmacol 65:193-208.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 193-208
-
-
Alfonso, A.1
de la Rosa, L.2
Vieytes, M.R.3
Yasumoto, T.4
Botana, L.M.5
-
2
-
-
0035923665
-
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
-
Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW. 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A 98:13681-13686.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 13681-13686
-
-
Bennett, B.L.1
Sasaki, D.T.2
Murray, B.W.3
O'Leary, E.C.4
Sakata, S.T.5
Xu, W.6
Leisten, J.C.7
Motiwala, A.8
Pierce, S.9
Satoh, Y.10
Bhagwat, S.S.11
Manning, A.M.12
Anderson, D.W.13
-
3
-
-
0034667705
-
Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons
-
Coffey ET, Hongisto V, Dickens M, Davis RJ, Courtney MJ. 2000. Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons. J Neurosci 20:7602-7613.
-
(2000)
J Neurosci
, vol.20
, pp. 7602-7613
-
-
Coffey, E.T.1
Hongisto, V.2
Dickens, M.3
Davis, R.J.4
Courtney, M.J.5
-
4
-
-
0011486518
-
Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro
-
Contestabile A. 2002. Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro. Cerebellum 1:41-55.
-
(2002)
Cerebellum
, vol.1
, pp. 41-55
-
-
Contestabile, A.1
-
5
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ. 2000. Signal transduction by the JNK group of MAP kinases. Cell 103:239-252.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
6
-
-
13844262643
-
The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways
-
Guan QH, Pei DS, Zhang QG, Hao ZB, Xu TL, Zhang GY. 2005. The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways. Brain Res 1035:51-59.
-
(2005)
Brain Res
, vol.1035
, pp. 51-59
-
-
Guan, Q.H.1
Pei, D.S.2
Zhang, Q.G.3
Hao, Z.B.4
Xu, T.L.5
Zhang, G.Y.6
-
7
-
-
0033974774
-
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland
-
Ito E, Satake M, Ofuji K, Kurita N, McMahon T, James K, Yasumoto T. 2000. Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. Toxicon 38:917-930.
-
(2000)
Toxicon
, vol.38
, pp. 917-930
-
-
Ito, E.1
Satake, M.2
Ofuji, K.3
Kurita, N.4
McMahon, T.5
James, K.6
Yasumoto, T.7
-
8
-
-
0036027438
-
Chronic effects in mice caused by oral administration of sublethal doses of azaspiracid, a new marine toxin isolated from mussels
-
Ito E, Satake M, Ofuji K, Higashi M, Harigaya K, McMahon T, Yasumoto T. 2002. Chronic effects in mice caused by oral administration of sublethal doses of azaspiracid, a new marine toxin isolated from mussels. Toxicon 40:193-203.
-
(2002)
Toxicon
, vol.40
, pp. 193-203
-
-
Ito, E.1
Satake, M.2
Ofuji, K.3
Higashi, M.4
Harigaya, K.5
McMahon, T.6
Yasumoto, T.7
-
9
-
-
0035998316
-
First evidence of an extensive northern European distribution of azaspiracid poisoning (AZP) toxins in shellfish
-
James KJ, Furey A, Lehane M, Ramstad H, Aune T, Hovgaard P, Morris S, Higman W, Satake M, Yasumoto T. 2002. First evidence of an extensive northern European distribution of azaspiracid poisoning (AZP) toxins in shellfish. Toxicon 40:909-915.
-
(2002)
Toxicon
, vol.40
, pp. 909-915
-
-
James, K.J.1
Furey, A.2
Lehane, M.3
Ramstad, H.4
Aune, T.5
Hovgaard, P.6
Morris, S.7
Higman, W.8
Satake, M.9
Yasumoto, T.10
-
10
-
-
0037305986
-
Ubiquitous "benign" alga emerges as the cause of shellfish contamination responsible for the human toxic syndrome, azaspiracid poisoning
-
James KJ, Moroney C, Roden C, Satake M, Yasumoto T, Lehane M, Furey A. 2003a. Ubiquitous "benign" alga emerges as the cause of shellfish contamination responsible for the human toxic syndrome, azaspiracid poisoning. Toxicon 41:145-151.
-
(2003)
Toxicon
, vol.41
, pp. 145-151
-
-
James, K.J.1
Moroney, C.2
Roden, C.3
Satake, M.4
Yasumoto, T.5
Lehane, M.6
Furey, A.7
-
11
-
-
0037355392
-
Detection of five new hydroxyl analogues of azaspiracids in shellfish using multiple tandem mass spectrometry
-
James KJ, Sierra MD, Lehane M, Brana Magdalena A, Furey A. 2003b. Detection of five new hydroxyl analogues of azaspiracids in shellfish using multiple tandem mass spectrometry. Toxicon 41:277-283.
-
(2003)
Toxicon
, vol.41
, pp. 277-283
-
-
James, K.J.1
Sierra, M.D.2
Lehane, M.3
Brana Magdalena, A.4
Furey, A.5
-
12
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
Kyriakis JM, Avruch J. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869.
-
(2001)
Physiol Rev
, vol.81
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
13
-
-
0141767093
-
The first identification of azaspiracids in shellfish from France and Spain
-
Magdalena AB, Lehane M, Krys S, Fernandez ML, Furey A, James KJ. 2003. The first identification of azaspiracids in shellfish from France and Spain. Toxicon 42:105-108.
-
(2003)
Toxicon
, vol.42
, pp. 105-108
-
-
Magdalena, A.B.1
Lehane, M.2
Krys, S.3
Fernandez, M.L.4
Furey, A.5
James, K.J.6
-
14
-
-
33645101470
-
A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption
-
Muller GJ, Geist MA, Veng LM, Willesen MG, Johansen FF, Leist M, Vaudano E. 2006. A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption. J Neurochem 96:1242-1252.
-
(2006)
J Neurochem
, vol.96
, pp. 1242-1252
-
-
Muller, G.J.1
Geist, M.A.2
Veng, L.M.3
Willesen, M.G.4
Johansen, F.F.5
Leist, M.6
Vaudano, E.7
-
15
-
-
0042035641
-
Total synthesis of the proposed azaspiracid-1 structure, part 2: Coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis
-
Nicolaou KC, Chen DY, Li Y, Qian W, Ling T, Vyskocil S, Koftis TV, Govindasamy M, Uesaka N. 2003. Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis. Angew Chem Int Ed Engl 42:3649-3653.
-
(2003)
Angew Chem Int Ed Engl
, vol.42
, pp. 3649-3653
-
-
Nicolaou, K.C.1
Chen, D.Y.2
Li, Y.3
Qian, W.4
Ling, T.5
Vyskocil, S.6
Koftis, T.V.7
Govindasamy, M.8
Uesaka, N.9
-
16
-
-
4544298099
-
Structural revision and total synthesis of azaspiracid-1, part 1: Intelligence gathering and tentative proposal
-
Nicolaou KC, Vyskocil S, Koftis TV, Yamada YM, Ling T, Chen DY, Tang W, Petrovic G, Frederick MO, Li Y, Satake M. 2004. Structural revision and total synthesis of azaspiracid-1, part 1: intelligence gathering and tentative proposal. Angew Chem Int Ed Engl 43:4312-4318.
-
(2004)
Angew Chem Int Ed Engl
, vol.43
, pp. 4312-4318
-
-
Nicolaou, K.C.1
Vyskocil, S.2
Koftis, T.V.3
Yamada, Y.M.4
Ling, T.5
Chen, D.Y.6
Tang, W.7
Petrovic, G.8
Frederick, M.O.9
Li, Y.10
Satake, M.11
-
17
-
-
33644520246
-
Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product
-
Nicolaou KC, Chen DY, Li Y, Uesaka N, Petrovic G, Koftis TV, Bernal F, Frederick MO, Govindasamy M, Ling T, Pihko PM, Tang W, Vyskocil S. 2006a. Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product. J Am Chem Soc 128:2258-2267.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 2258-2267
-
-
Nicolaou, K.C.1
Chen, D.Y.2
Li, Y.3
Uesaka, N.4
Petrovic, G.5
Koftis, T.V.6
Bernal, F.7
Frederick, M.O.8
Govindasamy, M.9
Ling, T.10
Pihko, P.M.11
Tang, W.12
Vyskocil, S.13
-
18
-
-
33748642999
-
-
Nicolaou KC, Frederick MO, Loizidou EZ, Petrovic G, Cole KP, Koftis TV, Yamada YMA. 2006b. Second generation total synthesis of azaspiracids-1, -2, and -3. Chem Asian J 1:245-251.
-
(2006)
Second generation total synthesis of azaspiracids-1, -2, and -3. Chem Asian
, vol.J 1
, pp. 245-251
-
-
Nicolaou, K.C.1
Frederick, M.O.2
Loizidou, E.Z.3
Petrovic, G.4
Cole, K.P.5
Koftis, T.V.6
Yamada, Y.M.A.7
-
20
-
-
33644942388
-
Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1
-
Nicolaou KC, Koftis TV, Vyskocil S, Petrovic G, Tang W, Frederick MO, Chen DY, Li Y, Ling T, Yamada YM. 2006d. Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1. J Am Chem Soc 128:2859-2872.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 2859-2872
-
-
Nicolaou, K.C.1
Koftis, T.V.2
Vyskocil, S.3
Petrovic, G.4
Tang, W.5
Frederick, M.O.6
Chen, D.Y.7
Li, Y.8
Ling, T.9
Yamada, Y.M.10
-
21
-
-
33644520879
-
Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure
-
Nicolaou KC, Pihko PM, Bernal F, Frederick MO, Qian W, Uesaka N, Diedrichs N, Hinrichs J, Koftis TV, Loizidou E, Petrovic G, Rodriquez M, Sarlah D, Zou N. 2006e. Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure. J Am Chem Soc 128:2244-2257.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 2244-2257
-
-
Nicolaou, K.C.1
Pihko, P.M.2
Bernal, F.3
Frederick, M.O.4
Qian, W.5
Uesaka, N.6
Diedrichs, N.7
Hinrichs, J.8
Koftis, T.V.9
Loizidou, E.10
Petrovic, G.11
Rodriquez, M.12
Sarlah, D.13
Zou, N.14
-
22
-
-
0033390733
-
Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland
-
Ofuji K, Satake M, McMahon T, Silke J, James KJ, Naoki H, Oshima Y, Yasumoto T. 1999a. Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland. Nat Toxins 7:99-102.
-
(1999)
Nat Toxins
, vol.7
, pp. 99-102
-
-
Ofuji, K.1
Satake, M.2
McMahon, T.3
Silke, J.4
James, K.J.5
Naoki, H.6
Oshima, Y.7
Yasumoto, T.8
-
23
-
-
0033286128
-
A sensitive and specific determination method for azaspiracids by liquid chromatography mass spectrometry
-
Ofuji K, Satake M, Oshima Y, McMahon T, James KJ, Yasumoto T. 1999b. A sensitive and specific determination method for azaspiracids by liquid chromatography mass spectrometry. Nat Toxins 7:247-250.
-
(1999)
Nat Toxins
, vol.7
, pp. 247-250
-
-
Ofuji, K.1
Satake, M.2
Oshima, Y.3
McMahon, T.4
James, K.J.5
Yasumoto, T.6
-
24
-
-
0035289355
-
Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe
-
Ofuji K, Satake M, McMahon T, James KJ, Naoki H, Oshima Y, Yasumoto T. 2001. Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe. Biosci Biotechnol Biochem 65:740-742.
-
(2001)
Biosci Biotechnol Biochem
, vol.65
, pp. 740-742
-
-
Ofuji, K.1
Satake, M.2
McMahon, T.3
James, K.J.4
Naoki, H.5
Oshima, Y.6
Yasumoto, T.7
-
25
-
-
6344278381
-
2+], and pH
-
2+], and pH. Chem Res Toxicol 17:1338-1349.
-
(2004)
Chem Res Toxicol
, vol.17
, pp. 1338-1349
-
-
Roman, Y.1
Alfonso, A.2
Vieytes, M.R.3
Ofuji, K.4
Satake, M.5
Yasumoto, T.6
Botana, L.M.7
-
26
-
-
0032582026
-
Azaspiracid, a new marine toxin having unique spiro ring assemblies, isolated from Irish mussels, Mytilus edulis
-
Satake M, Ofuji K, Naoki H, James KJ, Furey A, McMahon T, Silke J, Yasumoto T. 1998. Azaspiracid, a new marine toxin having unique spiro ring assemblies, isolated from Irish mussels, Mytilus edulis. J Am Chem Soc 120:9967-9968.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 9967-9968
-
-
Satake, M.1
Ofuji, K.2
Naoki, H.3
James, K.J.4
Furey, A.5
McMahon, T.6
Silke, J.7
Yasumoto, T.8
-
27
-
-
0022323906
-
Cultured neurons as model systems for biochemical and pharmacological studies on receptors for neurotransmitter amino acids
-
Schousboe A, Drejer J, Hansen GH, Meier E. 1985. Cultured neurons as model systems for biochemical and pharmacological studies on receptors for neurotransmitter amino acids. Dev Neurosci 7:252-262.
-
(1985)
Dev Neurosci
, vol.7
, pp. 252-262
-
-
Schousboe, A.1
Drejer, J.2
Hansen, G.H.3
Meier, E.4
-
28
-
-
0001607156
-
Preparation of primary cultures of mouse (rat) cerebellar granule cells
-
Shahar A, de Vellis J, Vernadakis A, Haber B, editors, New York: Alan R Liss. p
-
Schousboe A, Meier E, Drejer J, Hertz L. 1989. Preparation of primary cultures of mouse (rat) cerebellar granule cells. In: Shahar A, de Vellis J, Vernadakis A, Haber B, editors. A dissection and tissue culture manual of the nervous system. New York: Alan R Liss. p 203-206.
-
(1989)
A dissection and tissue culture manual of the nervous system
, pp. 203-206
-
-
Schousboe, A.1
Meier, E.2
Drejer, J.3
Hertz, L.4
-
29
-
-
0035166616
-
The neuronal MAP kinase cascade: A biochemical signal integration system subserving synaptic plasticity and memory
-
Sweatt JD. 2001. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76:1-10.
-
(2001)
J Neurochem
, vol.76
, pp. 1-10
-
-
Sweatt, J.D.1
-
30
-
-
19344378520
-
Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines
-
Twiner MJ, Hess P, Dechraoui MY, McMahon T, Samons MS, Satake M, Yasumoto T, Ramsdell JS, Doucette GJ. 2005. Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines. Toxicon 45:891-900.
-
(2005)
Toxicon
, vol.45
, pp. 891-900
-
-
Twiner, M.J.1
Hess, P.2
Dechraoui, M.Y.3
McMahon, T.4
Samons, M.S.5
Satake, M.6
Yasumoto, T.7
Ramsdell, J.S.8
Doucette, G.J.9
-
33
-
-
33744913282
-
Modulation of calcium entry and glutamate release in cultured cerebellar granule cells by palytoxin
-
Vale C, Alfonso A, Sunol C, Vieytes MR, Botana LM. 2006. Modulation of calcium entry and glutamate release in cultured cerebellar granule cells by palytoxin. J Neurosci Res 83:1393-1406.
-
(2006)
J Neurosci Res
, vol.83
, pp. 1393-1406
-
-
Vale, C.1
Alfonso, A.2
Sunol, C.3
Vieytes, M.R.4
Botana, L.M.5
-
34
-
-
35848947250
-
The c-Jun N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1
-
Vale C, Goḿez-Limia B, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. 2007a. The c-Jun N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1. Cell Physiol Biochem 20:957-966.
-
(2007)
Cell Physiol Biochem
, vol.20
, pp. 957-966
-
-
Vale, C.1
Goḿez-Limia, B.2
Nicolaou, K.C.3
Frederick, M.O.4
Vieytes, M.R.5
Botana, L.M.6
-
35
-
-
33846404512
-
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study
-
Vale C, Nicolaou KC, Frederick MO, Gomez-Limia B, Alfonso A, Vieytes MR, Botana LM. 2007b. Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study. J Med Chem 50:356-363.
-
(2007)
J Med Chem
, vol.50
, pp. 356-363
-
-
Vale, C.1
Nicolaou, K.C.2
Frederick, M.O.3
Gomez-Limia, B.4
Alfonso, A.5
Vieytes, M.R.6
Botana, L.M.7
-
36
-
-
0029873997
-
Characterization of a chemical anoxia model in cerebellar granule neurons using sodium azide: Protection by nifedipine and MK-801
-
Varming T, Drejer J, Frandsen A, Schousboe A. 1996. Characterization of a chemical anoxia model in cerebellar granule neurons using sodium azide: protection by nifedipine and MK-801. J Neurosci Res 44:40-46.
-
(1996)
J Neurosci Res
, vol.44
, pp. 40-46
-
-
Varming, T.1
Drejer, J.2
Frandsen, A.3
Schousboe, A.4
|