Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity: Effect of yessotoxin on cAMP levels in human lymphocytes

Biochemical Pharmacology

Volumn 65, Issue 2, 2003, Pages 193-208

  Alfonso, Amparo ^a   De la Rosa, Laura ^a,c   Vieytes, Mercedes R ^a   Yasumoto, Takeshi ^b   Botana, Luis M ^a  

^a Department of Agricultural and Forestry Engineering   (Spain)

^b JAPAN FOOD RESEARCH LABORATORIES   (Japan)

^c UNIVERSIDAD AUTÓNOMA DE CIUDAD JUÁREZ   (Mexico)

Author keywords

cAMP; Cytosolic calcium; Interleukin 2; Lymphocytes; Phosphodiesterase; Yessotoxin

Indexed keywords

ADENYLATE CYCLASE; CALCIUM ION; CHLORPROMAZINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DYE; ETAZOLATE; FLUORESCEIN; FORSKOLIN; INTERLEUKIN 2; MILRINONE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; RHODAMINE; ROLIPRAM; TOXIN; UNCLASSIFIED DRUG; YESSOTOXIN;

ARTICLE; BRAIN; CARDIOTOXICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DETERMINATION; TARGET CELL;

CYCLIC AMP; ENZYME ACTIVATION; ETHERS, CYCLIC; HUMANS; INTERLEUKIN-2; LYMPHOCYTES; MOLLUSK VENOMS; OXOCINS; PHOSPHORIC DIESTER HYDROLASES;

EID: 0037437764     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01454-5     Document Type: Article

References (30)

1. Murata M., Kumagai M., Lee J.S., Yasumoto T. Isolation and structure of Yessotoxin, a novel polyether compound implicated in diarrhetic shellfish poisoning. Tetrahedron Lett. 28:1987;5869-5872.
2. Draisci R, Lucentini L, Mascioni A. Enteric toxic episodes. Pectenotoxins and yessotoxins: chemistry, toxicology, pharmacology and analysis. In: Botana LM, editor. Seafood and freshwater toxins: pharmacology, physiology and detection. New York: Marcel Dekker; 2000, p. 289-324.
3. Lewis RJ, Molgó J, Adams DJ. Ciguatera toxins: Pharmacology of toxins involved in ciguatera and related fish poisonings. In: Botana LM, editor. Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection. New York: Marcel Dekker; 2000, p. 419-48.
4. Baden DG, Adams DJ. Brevetoxins: Chemistry, mechanism of action, and methods of detection. In: Botana LM, editor. Seafood and freshwater toxins: pharmacology, physiology and detection. New York: Marcel Dekker; 2000, p. 505-32.
5. Vieytes M.R., Fontal O.I., Leira F., Vieites J.M., Botana L.M. A fluorescent microplate assay for diarrheic shellfish toxins. Anal. Biochem. 248(2):1997;258-264.
6. Ogino H., Kumagai M., Yasumoto T. Toxicologic evaluation of yessotoxin. Nat. Toxins. 5:1997;255-259.
7. Terao K., Ito E., Oarada M., Murata M., Yasumoto T. Histopathological studies on experimental marine toxin poisoning. 5. The effects in mice of yessotoxin isolated from Patinopecten yessoensis and of a desulfated derivative. Toxicon. 28:1990;1095-1104.
8. de la Rosa L.A., Alfonso A., Vilariño N., Vieytes M.R., Botana L.M. Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin. Biochem. Pharmacol. 61(7):2001;827-833.
9. 2+ channel blockers and kinases. Cell Signal. 13(10):2001;711-716.
10. - exchangers in human lymphocytes. Naunyn Schmiedebergs Arch. Pharmacol. 365(1):2002;74-81.
11. de la Rosa L.A., Vilariño N., Vieytes M.R., Botana L.M. Modulation of thapsigargin-induced calcium mobilisation by cyclic AMP-elevating agents in human lymphocytes is insensitive to the action of the protein kinase A inhibitor H-89. Cell Signal. 13:2001;441-449.
12. Alfonso A., Cabado A.G., Vieytes M.R., Botana L.M. Functional compartments in rat mast cells for cAMP and calcium on histamine release. Cell Signal. 12:2000;343-350.
13. - transporter in human lymphocytes. Pflugers Arch. 437(6):1999;935-943.
14. Hiratsuka T. New fluorescent analogs of cAMP and cGMP available as substrates for cyclic nucleotide phosphodiesterase. J. Biol. Chem. 257:1982;13354-13358.
15. Adams S.R., Harootunian A.T., Buechler Y.J., Taylor S.S., Tsien R.Y. Fluorescence ratio imaging of cyclic AMP in single cells. Nature. 349(6311):1991;694-697.
16. Botana L.M., MacGlashan D.W. Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils. J. Leukoc. Biol. 55(6):1994;798-804.
17. Wang P., Myers J., Wu P., Cheewatrakoolpong B., Egan R.W., Billah M.M. Expression purification and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. Biochem. Biophys. Res. Commun. 234:1997;320-324.
18. Pyne N.J., Cooper M.E., Houslay M.D. The insulin- and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity. Biochem. J. 242(1):1987;33-42.
19. Nicholson C.D., Challis R.A.J., Shahid M. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol. Sci. 12(1):1991;19-27.
20. Alfonso A., Estévez M., Louzao M.C., Vieytes M.R., Botana L.M. Determination of phosphodiesterase activity in rat mast cells using the fluorescent cAMP analogue anthraniloyl cAMP. Cell Signal. 7(5):1995;513-518.
21. Hogan Y.H., Florent G., Hussain T., Alkadhi K.A. Cyclic AMP antagonizes adenosine-induced inhibition of ganglionic transmission. Brain Res. 787:1998;242-247.
22. Sagi-Eisenberg R. Activation of heterotrimeric GTP-binding proteins. In: Razin E, Rivera J, editors. Signal Transduction in Mast Cells and Basophils. New York: Springer; 1999, p. 286-300.
23. 2+-inhibitable adenylyl cyclase in C6-2B glioma cells. J. Biol. Chem. 274:1999;12445-12453.
24. 2+ entry. J. Biol. Chem. 273(15):1998;9297-9305.
25. Sheth S.B., Chaganti K., Bastepe M., Ajuria J., Brennan K., Biradavolu R., Colman R.W. Cyclic AMP phosphodiesterases in human lymphocytes. Br. J. Haematol. 99(4):1997;784-789.
26. Peachell P.T., Undem B.J., Schleimer R.P., MacGlashan D.W., Lichtenstein L.M., Cieslinski L.B., Torphy T.J. Preliminary identification and role of phosphodiesterase isozymes in human basophils. J. Immunol. 148(8):1992;2503-2510.
27. Beavo J.A., Reifsnyder D.H. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. TIPS. 128:1990;150-155.
28. Giembycz M.A., Corrigan C.J., Seybold J., Newton R., Barnes P.J. Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2. Br. J. Pharmacol. 118:1996;1945-1958.
29. Ohtsuka T., Kaziro Y., Satoh T. Analysis of the T-cell activation signaling pathway mediated by tyrosine kinases, protein kinase C, and Ras protein, which is modulated by intracellular cyclic AMP. Biochim. Biophys. Acta. 1310(2):1996;223-232.
30. Bodor J., Feigenbaum L., Bodorova J., Bare C., Reitz M.S.J., Gress R.E. Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER). J. Leukoc. Biol. 69(6):2001;1053-1059.